Atypical mycobacterial pulmonary disease and bronchial obstruction in HIV-negative children

Dore, Nigel D.; Lesouëf, Peter; Masters, Brent; Francis, P.; Cooper, David M.; Wildhaber, Johannes H.; Fall, A.; Sly, Peter D.

doi:10.1002/(sici)1099-0496(199812)26:6<380::aid-ppul2>3.0.co;2-i

Cited by 17 publications

(15 citation statements)

References 38 publications

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“…Other reports describe the endobronchial masses caused by NTM to be fleshy, mucoid, cheesy friable or rubbery gray-white. 20,25,27,35,36 Most commonly, the lesions were characterized as granulation tissue, although 1 author 25 noted a caseous node. In all our cases, endobronchial masses significantly obstructed a large bronchus; after debulking, an intact bronchial wall was found.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Lesions Caused by Nontuberculous Mycobacteria in Apparently Healthy Pediatric Patients

Kröner

Griese²,

Kappler³

et al. 2015

Pediatric Infectious Disease Journal

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Pulmonary disease caused by nontuberculous mycobacteria in healthy children is rare, and its pathogenesis is unknown in most cases and standardized treatment is lacking. Here, we report various endobronchial manifestations in 5 patients including hitherto undescribed diffuse tracheobronchial granulomas in 2 patients. Bronchoscopic debulking was performed in all patients and tuberculostatic treatment in 4. All patients including 1 without tuberculostatic treatment showed remission.

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Section: Discussionmentioning

confidence: 99%

Endobronchial Lesions Caused by Nontuberculous Mycobacteria in Apparently Healthy Pediatric Patients

Kröner

Griese²,

Kappler³

et al. 2015

Pediatric Infectious Disease Journal

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“…Nontuberculous mycobacterial (NTM) pulmonary disease is rare in immunocompetent children. Dore and colleagues, in 1998, described 10 cases diagnosed in Australian children over the last 10 years 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Despite hilar lymphadenopathy being the cause of the obstructive symptoms in this child, this pathology was not evident on plain radiographs of the chest. In the series of 10 cases described by Dore and colleagues, only two had hilar lymph node enlargement seen on chest X‐ray 3 . Often the true nature of the pathology is only discovered by CT of the chest or by direct visualization at the time of bronchoscopy.…”

Section: Discussionmentioning

confidence: 99%

A foreign body alternative

May

2004

J Paediatrics Child Health

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“…Although IGRA has not yet been widely tested in subjects with non-tuberculous mycobacterial infection, M. kansasii, M. szulgai, M. marinum, and M bovis may also yield positive results, as they share some common antigens [49,50] However these assays cannot distinguish latent from active TB infection as positivity merely indicates an exposure to Mycobacterium tuberculosis. Likewise, a positive TST may not distinguish between active disease and atypical mycobacterial infection and a negative avian Mantoux test does not exclude the latter diagnoses [51]. There are numerous causes for false-positive and false-negative interpretations of the TST [52].…”

Section: Reviewmentioning

confidence: 99%

Diagnostic techniques for inflammatory eye disease: past, present and future: a review

Teoh

Dick

2013

BMC Ophthalmol

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Investigations used to aid diagnosis and prognosticate outcomes in ocular inflammatory disorders are based on techniques that have evolved over the last two centuries have dramatically evolved with the advances in molecular biological and imaging technology. Our improved understanding of basic biological processes of infective drives of innate immunity bridging the engagement of adaptive immunity have formed techniques to tailor and develop assays, and deliver targeted treatment options. Diagnostic techniques are paramount to distinguish infective from non-infective intraocular inflammatory disease, particularly in atypical cases. The advances have enabled our ability to multiplex assay small amount of specimen quantities of intraocular samples including aqueous, vitreous or small tissue samples. Nevertheless to achieve diagnosis, techniques often require a range of assays from traditional hypersensitivity reactions and microbe specific immunoglobulin analysis to modern molecular techniques and cytokine analysis. Such approaches capitalise on the advantages of each technique, thereby improving the sensitivity and specificity of diagnoses. This review article highlights the development of laboratory diagnostic techniques for intraocular inflammatory disorders now readily available to assist in accurate identification of infective agents and appropriation of appropriate therapies as well as formulating patient stratification alongside clinical diagnoses into disease groups for clinical trials.

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Atypical mycobacterial pulmonary disease and bronchial obstruction in HIV-negative children

Cited by 17 publications

References 38 publications

Endobronchial Lesions Caused by Nontuberculous Mycobacteria in Apparently Healthy Pediatric Patients

Endobronchial Lesions Caused by Nontuberculous Mycobacteria in Apparently Healthy Pediatric Patients

A foreign body alternative

Diagnostic techniques for inflammatory eye disease: past, present and future: a review

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