Atypical mole syndrome and dysplastic nevi: identification of populations at risk for developing melanoma - review article

Silva, Juliana Hypólito; Sá, Bianca Costa Soares de; Avila, Alexandre; Landman, Gilles; Neto, João Pedreira Duprat

doi:10.1590/s1807-59322011000300023

Cited by 37 publications

(17 citation statements)

References 52 publications

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“…(5) It has been estimated that familial dysplastic nevus syndrome affects approximately 32,000 individuals in the United States and has an estimated relative risk of 82% in individuals aged 72 years. (3,6) Clinically, atypical moles are larger (> 0.5 cm in diameter) than other types of nevi, have irregular and indistinct margins, and exhibit variegated pigmentation. They may be macules, papules or plaques.…”

Section: Dysplastic Nevusmentioning

confidence: 99%

“…These lesions usually occur in puberty and may continue to appear throughout life. (6) The histologic features of dysplastic nevi include: extension of the junctional component of the nevus beyond the dermal component (shoulder phenomenon); anastomosing, horizontally oriented melanocytic nests with fusion of the adjacent rete ridges; subepidermal lamellar fibroplasia parallel to the epidermis; concentric eosinophilic fibroplasia surrounding melanocytic nests; and lymphohistiocytic inflammatory infiltrate (Fig. 1).…”

Section: Dysplastic Nevusmentioning

confidence: 99%

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Histologic mimics of malignant melanoma

Bsirini

Smoller

2018

smedj

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Although spongiotic (eczematous), psoriatic and cutaneous skin infections are among the most common in dermatology consultations, melanocytic lesions - including the different types of nevi and melanomas - are among those that cause a great deal of concern and stress to patients and their clinicians. A diagnosis of benign melanocytic nevus carries a very good prognosis. However, a diagnosis of melanoma might indicate more aggressive treatment, lifelong surveillance and a worse prognosis. Differentiating between these conditions is not always a straightforward process for clinicians and pathologists. Therefore, knowledge of melanoma mimickers is very important for clinicians in general, and dermatologists and pathologists in particular. In this review, we called attention to some of the more frequent benign but unusual melanocytic lesions that are of diagnostic concern for clinicians evaluating these cutaneous proliferations.

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Section: Dysplastic Nevusmentioning

confidence: 99%

Section: Dysplastic Nevusmentioning

confidence: 99%

Histologic mimics of malignant melanoma

Bsirini

Smoller

2018

smedj

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“…Sporadic and Familial Atypical Mole Syndromes are the most important phenotypic risk factors for developing cutaneous melanoma, a malignancy that accounts for about 80 % of deaths from skin cancer [5]. Because the early diagnosis of melanoma is of great prognostic relevance, the identification of AMS carriers (sporadic and familial) is of great importance, as well as the recommendation of preventative measures to be applied in these patients [5].…”

Section: Introductionmentioning

confidence: 99%

“…Because the early diagnosis of melanoma is of great prognostic relevance, the identification of AMS carriers (sporadic and familial) is of great importance, as well as the recommendation of preventative measures to be applied in these patients [5].…”

Section: Introductionmentioning

confidence: 99%

Multiple primary cutaneous melanomas in patients with FAMMM syndrome and sporadic atypical mole syndrome (AMS): What’s worse?

Tchernev

Ananiev

Cardoso

et al. 2014

Wien Med Wochenschr

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Atypical Mole Syndrome is the most important phenotypic risk factor for cutaneous melanoma, a malignancy that accounts for about 80% of deaths from skin cancer. Since early diagnosis of melanoma is of great prognostic relevance, the identification of Atypical Mole Syndrome carriers (sporadic and familial) is essential, as well as the recommendation of preventative measures that must be undertaken by these patients.We report two rare cases concerning patients with multiple primary skin melanomas in the setting of a familial and a sporadic syndrome of dysplastic nevi: the first patient is a 67-year-old patient with a history of multiple superficial spreading melanomas localized on his back. The second patient presented with multiple primary melanomas in advanced stage in the context of the so-called sporadic form of the syndrome of dysplastic nevi-AMS (atypical mole syndrome). In the first case, excision of the melanomas was carried out with an uneventful post-operative period. In the second case, disseminated metastases were detected, involving the right fibula, the abdominal cavity as well as multiple lesions in the brain. The patient declined BRAF mutation tests as well as chemotherapy or targeted therapies, and suffered a rapid deterioration in his general condition leading to death. We classified the second case as a sporadic form of the atypical mole syndrome, associated with one nodular and two superficial spreading melanomas.There are no data in the literature to allow us to understand if, in patients with multiple primary melanomas, there is any difference in terms of prognosis between those with and without a family history of a similar phenotype. To answer this and other questions related to these rare cases, further studies with a significant number of patients should be carried out.

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“…Melanoma is the most aggressive skin cancer [1] responsible for 80% of lethal cases [2,3]. The malignant tumor arises from transformed melanocytes, which originate from the neural-crest and accumulate genomic mutations leading to uncontrolled proliferation, invasion, and metastasis [4,5].…”

mentioning

confidence: 99%

AC‐1001 H3 CDR peptide induces apoptosis and signs of autophagy in vitro and exhibits antimetastatic activity in a syngeneic melanoma model

et al. 2016

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Antibody‐derived peptides modulate functions of the immune system and are a source of anti‐infective and antitumor substances. Recent studies have shown that they comprise amino acid sequences of immunoglobulin complementarity‐determining regions, but also fragments of constant regions. VH CDR3 of murine mAb AC‐1001 displays antimetastatic activities using B16F10‐Nex2 murine melanoma cells in a syngeneic model. The peptide was cytotoxic in vitro in murine and human melanoma cells inducing reactive oxygen species (ROS) and apoptosis by the intrinsic pathway. Signs of autophagy were also suggested by the increased expression of LC3/LC3II and Beclin 1 and by ultrastructural evidence. AC‐1001 H3 bound to both G‐ and F‐actin and inhibited tumor cell migration. These results are important evidence of the antitumor activity of Ig CDR‐derived peptides.

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Atypical mole syndrome and dysplastic nevi: identification of populations at risk for developing melanoma - review article

Cited by 37 publications

References 52 publications

Histologic mimics of malignant melanoma

Histologic mimics of malignant melanoma

Multiple primary cutaneous melanomas in patients with FAMMM syndrome and sporadic atypical mole syndrome (AMS): What’s worse?

AC‐1001 H3 CDR peptide induces apoptosis and signs of autophagy in vitro and exhibits antimetastatic activity in a syngeneic melanoma model

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