Atypical memory B cell frequency correlates with antibody breadth and function in malaria immune adults
Frederica Dedo Partey,
Jasmine Naa Norkor Dowuona,
Abigail Naa Adjorkor Pobee
et al.
Abstract:Clinical immunity to malaria develops slowly after repeated episodes of infection and antibodies are essential in naturally acquired immunity against malaria. However, chronic exposure to malaria has been linked to perturbation in B-cell homeostasis with the accumulation of atypical memory B cells. It is unclear how perturbations in B cell subsets influence antibody breadth, avidity, and function in individuals naturally exposed to malaria. We show that individuals living in high malaria transmission regions i… Show more
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