Atypical Melanosis of the Foot

Nogita, Toshitatsu; Wong, Ting-Kam Leonard; Ohara, Kuniaki; Mizushima, Junichi; Mihm, Martín C.; Kawashima, Makoto

doi:10.1001/archderm.1994.01690080108016

Cited by 34 publications

(12 citation statements)

References 21 publications

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“…Atypical melanosis of the foot was first described by Nogita et al 1,2 The authors described three patients whose lesions were clinically suspicious for melanoma by their asymmetric shape and irregular and variegated pigmentation, but there was no evident feature of malignancy histopathologically with only dispersed foci of slight increase in dentritic melanocytes with minimal cytological atypia. Besides, the first case they reported had a slowly enlarging lesion with an 18-year history which is an unusual feature for acral melanoma.…”

Section: Discussionmentioning

confidence: 99%

“…There have been some unusual cases reported in the published work which were clinically compatible with early acral melanomas due to their large size, asymmetry and irregular pigmentation, but at the same time had unexpectedly long histories, mostly over a decade, and subtle histopathological findings. Such cases were initially called "atypical melanosis of the foot" by Nogita et al 1,2 Herein, we report an additional unusual case which was suspicious for acral lentiginous melanoma (ALM) in situ, showing its clinical and dermoscopic features, but a long history. We report it as a case of atypical melanosis of the foot (AMF) because histopathological findings were not prominent enough to diagnose it as a melanoma in situ.…”

Section: Introductionmentioning

confidence: 89%

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Atypical melanosis of the foot showing a dermoscopic feature of the parallel ridge pattern

Karaarslan¹,

Ünal²,

Özdemir³

2006

The Journal of Dermatology

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A 62-year-old male Turkish patient had a pigmented lesion on the sole with a 10-year history. It was an asymmetrical macular lesion with an irregular border and irregular brown pigmentation and had a diameter of 1.2 cm x 1.7 cm. Dermoscopy revealed a parallel ridge pattern and an abrupt cut-off of pigmentation on the upper edge. Histologically lentiginous hyperplasia decorated by innocent melanocytes and scattered melanocytic proliferation with slight to moderate cytological atypia were seen. Atypical melanocytes were very scattered and it was insufficient to call it a melanoma in situ. A second finding was a microvascular proliferation located in the papillary dermis. There was no sign of regression such as fibrous tissue or host reaction. Atypical melanosis of the foot has rarely been reported in the published work, which are from Japan and Korea. This case is presented to emphasize the significance of this rare entity which has recently been reported to be a very early phase of acral melanoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Atypical melanosis of the foot showing a dermoscopic feature of the parallel ridge pattern

Karaarslan¹,

Ünal²,

Özdemir³

2006

The Journal of Dermatology

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“…20 'Atypical melanosis of the foot' is also used in the sole. 21,22 However, only a few histological data are available for these lesions. Recently, Karaarslan et al stated that atypical melanosis of the foot demonstrated a parallel ridge pattern dermoscopically, as well as lentiginous hyperplasia of melanocytes mainly in the crista profunda intermedia histopathologically, with slight to moderate cytological atypia.…”

Section: Discussionmentioning

confidence: 99%

Reassessment of histopathology and dermoscopy findings in 145 Japanese cases of melanocytic nevus of the sole: Toward a pathological diagnosis of early‐stage malignant melanoma in situ

Jin

Arai²,

Anzai

et al. 2010

Pathology International

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Recently, dermoscopic visualization has been improved, allowing for the identification of malignant melanoma (MM) of the sole in situ. When the parallel ridge pattern is evident on dermoscopy, the proliferation of solitarily arranged melanocytes in the crista profunda intermedia should be examined histologically, since this may be a clue to the early diagnosis of MM in situ. We reviewed 145 Japanese cases of melanocytic nevus on the sole, and investigated several useful histological features for the diagnosis of MM in situ using a recent proposal as well as several standard histological criteria of MM in situ. Five cases were considered to be an early-stage MM in situ out of 145 cases previously diagnosed as melanocytic nevi of the sole. These cases showed several specific features, including solitarily arranged melanocytes or melanocyte nests comprising fewer than four cells. Our findings indicate that early-stage MM of the sole in situ can be diagnosed by using new dermoscopy-related histological findings. They are (i) irregular distribution of solitary melanocytes at the crista profunda intermedia with or without small nests (up to three melanocytes) on the slope of rete ridges; and (ii) larger melanocytes with a halo around the nucleus.

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“…7,8 Clinical and/or histologic pictures of lentiginous nevus, however, occasionally mimic those of early acral melanoma, 8 and furthermore, some authors reported acral pigmented lesions that are suspected malignancy but have only minimal histopathologic change. 5,12,13 Thus, histopathologists as well as clinicians sometimes have difficulties in differentiating early acral melanoma from melanocytic nevus.…”

Section: Discussionmentioning

confidence: 99%

“…In the past, histopathologic examination has been used to define premalignant lesions of acral melanoma such as plantar or palmar premalignant melanosis, of which cellular characteristics appear to be similar to those of pagetoid premalignant melanosis or the radial phase of superficial spreading melanoma 7,8 . Clinical and/or histologic pictures of lentiginous nevus, however, occasionally mimic those of early acral melanoma, 8 and furthermore, some authors reported acral pigmented lesions that are suspected malignancy but have only minimal histopathologic change 5,12,13 . Thus, histopathologists as well as clinicians sometimes have difficulties in differentiating early acral melanoma from melanocytic nevus.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopy Identifies Histopathologically Indiscernible Malignant Lesion of Atypical Melanosis of the Foot, an Early Lesion of Acral Lentiginous Melanoma In Situ

Chiu¹,

Hu²,

Ke³

et al. 2008

Dermatologic Surgery

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Atypical Melanosis of the Foot

Cited by 34 publications

References 21 publications

Atypical melanosis of the foot showing a dermoscopic feature of the parallel ridge pattern

Atypical melanosis of the foot showing a dermoscopic feature of the parallel ridge pattern

Reassessment of histopathology and dermoscopy findings in 145 Japanese cases of melanocytic nevus of the sole: Toward a pathological diagnosis of early‐stage malignant melanoma in situ

Dermoscopy Identifies Histopathologically Indiscernible Malignant Lesion of Atypical Melanosis of the Foot, an Early Lesion of Acral Lentiginous Melanoma In Situ

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