Atypical melanocytic lesions of the thigh with spitzoid and dysplastic features: a clinicopathologic study of 29 cases

Buonaccorsi, J. Noelle; Lynott, James; Plaza, Jose A.

doi:10.1016/j.anndiagpath.2012.12.001

Cited by 9 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5,7,8 In the previous reports where clinical follow-up was available, no recurrences or metastases were observed. 7,8 In the current case series, residual proliferation was not observed in any of the excision specimens, con- gists. In a recent study, Spitz nevi and atypical Spitz tumors had especially low concordance rates of 25% and 40%, respectively.…”

Section: Resultsmentioning

confidence: 89%

“…13,14 Finally, the cases lesions. 5,7,8 Given that pagetoid Spitz nevus shares overlapping histopathological features with melanoma in situ, its diagnosis cannot be ren- ing the utility of these molecular-based tests. 10,11,15 In the initial 1995 report by Busam and Barnhill, the authors suggest that pagetoid Spitz nevi are "probably best treated as melanoma in situ."…”

Section: Resultsmentioning

confidence: 99%

“…The results herein confirm the findings of previous reports that pagetoid Spitz nevus is overrepresented on the thigh, occurring more frequently than other types of Spitz nevi at this site. 3,5,7 As pagetoid Spitz nevi characteristically have clinically benign appearances, appropriate management of this type of nevus requires close communication between the clinician and the pathologist to avoid overdiagnosis as melanoma or suggestive of melanoma. For equivocal cases, molecular-based adjunctive tests may provide additional diagnostic information.…”

Section: Discussionmentioning

confidence: 99%

“…The pagetoid Spitz nevus, a rare subtype of Spitz nevus, has been reported to occur most frequently on the lower extremities, particularly on the thigh of young women. [3][4][5][6][7][8] While the nevus has been described as having a clinically benign appearance in most cases, the histopathological findings, in contrast, have overlapping features with melanoma in situ, a diagnostic pitfall emphasized by all the authors (Figure 1). [3][4][5][6][7][8] As the thigh has been a particular site of interest for pagetoid Spitz nevus, a retrospective analysis of all melanocytic lesions from the thigh was performed to determine the frequency of this rare subtype of Spitz nevus and further characterize its clinical and histopathological features.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical and histopathological features of pagetoid Spitz nevi of the thigh

2020

View full text Add to dashboard Cite

Background: Pagetoid Spitz nevus is a rare subtype of Spitz nevus usually found on the lower extremities, particularly on the thigh of women. As a rare and underrecognized entity that can be misdiagnosed as melanoma, further characterization of clinical and histopathological features is needed to improve its recognition. Methods: A retrospective analysis of all melanocytic neoplasms from the thigh diagnosed over a 3-year period. Results: Fifty-five (15.4%) of the 357 melanocytic neoplasms on the thigh were Spitz nevi, the majority of them occurring in women (87.3%). Of the 55 Spitz nevi, 33 (60.0%) were pagetoid Spitz nevi, 14 (25.5%) were Reed nevi, and eight (14.5%) were conventional Spitz nevi. The mean age of patients with pagetoid Spitz nevi was 47.2, the majority being women (84.9%). Pagetoid Spitz nevi were small, with a mean histopathologic diameter of 4 mm, and often junctional (63.6%). Compared to Clark nevi of the thigh, pagetoid Spitz nevi comprised significantly more solitary melanocytes with a greater degree of scatter. Conclusions: These results suggest that Spitz nevi and, in particular, pagetoid Spitz nevi constitute a significant percentage of nevi on the thigh. Previously reported benign clinical and histopathological features of pagetoid Spitz nevi are confirmed in this study.

show abstract

Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and histopathological features of pagetoid Spitz nevi of the thigh

2020

View full text Add to dashboard Cite

show abstract

“…Flexural nevi that fit criteria for “special site” nevi may be clinically indistinguishable from other types of melanocytic nevi [ 2 ]. They are usually greater than 6 mm and have an irregular border [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Dermoscopic and confocal features of an axillary “special site” nevus

Dutt

Rabinovitz

Singh

et al. 2017

Dermatol Pract Concept

View full text Add to dashboard Cite

“Nevi of special sites” is a term that denotes melanocytic nevi presenting in specific anatomic locations including the scalp, genital area, flexural sites, and acral sites [1]. Nevi from these anatomic sites display at times histopathologic features that may lead the reading pathologist to recommend re-excision of these benign nevi. Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that allows for visualization of epidermal, dermal-epidermal junctional (DEJ), and superficial dermal tissue structures at cellular level resolution. RCM features of special site nevi have not been previously described in the literature. Defining the RCM characteristics of special site nevi may increase diagnostic accuracy and assist in ruling out melanoma. Here, we report a case of a pigmented lesion appearing in the axilla of a patient with a recently diagnosed melanoma. Dermoscopic and histopathologic results were consistent with the diagnosis of nevus in flexural anatomic sites. In this case, RCM showed a regular honeycomb pattern of epidermal keratinocytes and enlarged, non-homogenous, discohesive nests at the DEJ, a pattern that corresponded well with the histopathologic findings. Larger studies are needed to establish RCM features of special site nevi in order to reliably rule out melanoma and lower the rate of unnecessary excisions of these benign nevi.

show abstract