Atypical manifestations of congenital parvovirus B19 infection

Savarese, Immacolata; Carolis, Maria Pia De; Costa, Simonetta; Rosa, Gabriella De; Carolis, Sara De; Lacerenza, Serafina; Romagnoli, Costantino

doi:10.1007/s00431-008-0688-z

Cited by 15 publications

(12 citation statements)

References 9 publications

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“…Neurological symptoms, mainly developmental delays but also seizures and hydrocephalus, may be direct sequelae of viral infection or indirectly related to severe anemia in utero and at birth (587,592,593). Other diverse associations include ascites (594)(595)(596), bone lesions (597), and corneal opacification (598). Embryonic malformations have been seen in incomplete embryos after uterine infection (599).…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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“…Conditions associated with pleural effusion are either congenital or acquired (like maternal infections such as parvovirus B19 infection – inducing transient nonimmune hydrops fetalis [NIHF]). Approximately one‐third is congenital – of which majority is either a component of hydrops fetalis or chromosomal abnormalities .…”

Section: Discussionmentioning

confidence: 99%

Spontaneous resolution of prenatally diagnosed isolated pleural effusion: An unusual early sign of a newborn disease

Kajdy

Materny²,

Modzelewski

et al. 2019

J of Obstet and Gynaecol

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We present a case report of a fetus with a diagnosed pleural effusion in the first trimester on nuchal translucency scan. The effusion resolved spontaneously by 17 weeks of pregnancy. Toxoplasmosis, rubella, cytomegalovirus, herpes simplex (TORCH)negative. Array comparative genomic hybridization (aCGH)normal. Serial Doppler scans normalno prenatal signs of anemia. Maternal antibodies against red cell antigensnegative. Delivery at term by cesarean section because of macrosomia. Neonate suffered from prolonged jaundice. At 3 weeks of life diagnosed with hereditary spherocytosis. Literature review shows that this may be the first connection between this disease and prenatal life.

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“…In hydrops fetalis, nonchylous fluid accumulates in the different serous cavities (ascites, pericarditis, pleura), but widespread edema of subcutaneous fetal tissue is the main clinical manifestation [4]. It is thought, that hydrops fetalis caused by PV-B19 results from destruction of erythroid cells leading to subsequent fetal anemia which causes cardiac failure [5]. To the best of our knowledge there are only few publications reporting the association of isolated pleural or pericardial effusions and PV-B19 congenital infection [4,7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Common clinical symptoms are headache, coryza, low-grade fever, pharyngitis, and malaise, bright red erythema of the face and extremities, as well as polyarthropathy. During pregnancy PV-B19 infection can be asymptomatic or can cause a variety of signs of fetal damage (severe anemia, hydrops fetalis, death) [5]. In hydrops fetalis, nonchylous fluid accumulates in the different serous cavities (ascites, pericarditis, pleura), but widespread edema of subcutaneous fetal tissue is the main clinical manifestation [4].…”

Section: Discussionmentioning

confidence: 99%

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Critical cardiac tamponade in newborn, life-saving emergency interventions and possibility of parvovirus B19 congenital infection

Jaworski¹,

Haponiuk²,

Irga‐Jaworska

et al. 2013

Open Medicine

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AbstractThe presence of pericardial effusion in neonates usually indicates a poor prognosis. Here, we report a case of isolation of cardiac tamponade in a newly born. This may be related to vertical human parvovirus B19, an infection with atypical clinical manifestation. Any neonate with unexplained fetal pericardial effusion should always be tested for parvovirus B19 infection, even in the absence of known and proved fetal exposure. Despite the etiology of a tamponade the only reasonable procedure is a surgical evacuation during diagnosis.

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Atypical manifestations of congenital parvovirus B19 infection

Cited by 15 publications

References 9 publications

Human Parvoviruses

Human Parvoviruses

Spontaneous resolution of prenatally diagnosed isolated pleural effusion: An unusual early sign of a newborn disease

Critical cardiac tamponade in newborn, life-saving emergency interventions and possibility of parvovirus B19 congenital infection

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