Atypical manifestation of lung metastasis 17 years after initial diagnosis of low-grade central osteosarcoma

Fujiwara, Tomohiro; Oda, Mai; Yoshida, Akihiko; Chuman, Hirokazu; Kusumoto, Masahiko; Kawai, Akira

doi:10.1016/j.jos.2015.08.002

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…Because no significant symptoms in organs with metastasis can be observed at early stages, distant metastasis is difficult to be identified in a timely manner. Therefore, many cancer patients suffer distant metastases at the initial diagnosis 4,5 . The incidence of initial distant metastasis in osteosarcoma patients is approximately 15%, 6 and the accurate prevalence of metastasis is thought to be underestimated.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, many cancer patients suffer distant metastases at the initial diagnosis. 4,5 The incidence of initial distant metastasis in osteosarcoma patients is approximately 15%, 6 and the accurate prevalence of metastasis is thought to be underestimated. Cancer may be the most serious medical problem worldwide, and huge medical and monetary resources have been spent in the management of cancer prevention and treatment.…”

Section: Introductionmentioning

confidence: 99%

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Risk and Prognostic Factors for Different Organ Metastasis in Primary Osteosarcoma: A Large Population‐Based Analysis

Zhang

et al. 2022

Orthopaedic Surgery

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Objective: Based on a large public cohort, we aimed to investigate the prevalence of distant metastases in patients with osteosarcoma, to evaluate the survival of patients with different metastases and to reveal the related risk and prognostic factors for distant metastases. Methods:The information of osteosarcoma patients with or without distant metastases was retrospectively extracted from the Surveillance, Epidemiology, and End Result database from January 2010 to December 2015. Patients were excluded if they were diagnosed at autopsy or via death certification. The Kaplan-Meier method was used to calculate the overall survival in the entire cohort and across patients with metastases to different organs. The related prognostic factors were investigated by univariate and multivariate Cox proportional hazard regression analysis. The logistic regression method was used to reveal the risk factors for the development of different metastases. The effects of different variables on the survival and prevalence of distant metastases were compared using subgroup analysis. Variables with P < 0.05 in the univariate regression analysis were further examined using multivariate regression analysis.Results: In total, 1470 osteosarcoma patients (mean age 30 AE 22 years) were included, among which 278 patients (18.9%) were initially diagnosed with distant metastasis. The median follow-up duration was 33.0 (30.2-35.8) months. The lung was the most common metastatic site (83.8%), followed by the bone (21.9%), liver (2.9%), and brain (2.2%). A total of 232 patients (83.5%) presented only one distant metastatic site, while the other 46 patients showed two or more metastatic sites. A lower proportion of metastasis was observed in patients aged from 25 to 59 years [odds ratio (OR) = 0.59; 95% confidence interval (CI): 0.37-0.95]. More metastases were noted in patients with T2/T1 (

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk and Prognostic Factors for Different Organ Metastasis in Primary Osteosarcoma: A Large Population‐Based Analysis

Zhang

et al. 2022

Orthopaedic Surgery

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“…Owing to the easy metastasis and high invasiveness of osteosarcoma, metastasis is detected at the first clinical visit in 10-20% of osteosarcoma patients (19). The most common metastatic site of osteosarcoma is the lung, and the recurrence rate of osteosarcoma patients with lung metastasis is as high as 80% (20,21), which seriously threatens their survival and prognosis (22).…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel iron zinc finger protein 36 (ZFP36) for predicting the overall survival of osteosarcoma based on the Gene Expression Omnibus (GEO) database

et al. 2021

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“…[ 3 , 4 ] The lung is the most common metastatic site, and pulmonary metastasis typically occurs within 2 to 3 years after initial treatment. [ 5 – 7 ] Relapse occurring ≥10 years after an initial treatment for osteosarcoma is exceedingly uncommon and has been described in few reports. [ 5 , 8 – 15 ] We describe an extremely rare case of osteosarcoma that recurred as lung metastasis 38 years after the patient's initial treatment with surgery and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Very late relapse of high-grade osteosarcoma

Kaneuchi¹,

Hakozaki²,

Yamada³

et al. 2020

Medicine

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Rationale: Osteosarcoma is the most common primary malignant bone tumor in children. The prognosis of osteosarcoma has improved with the use of aggressive systemic chemotherapy in addition to surgery. The relapse of osteosarcomas is usually as lung metastasis observed within 2 to 3 years after the initial treatment. A relapse is rarely observed at >10 years. Patient concerns: We report the case of a 51-year-old Japanese man who was treated for high-grade osteosarcoma of the femur at 13 years old. He was referred to our hospital with a suspicion of primary lung cancer based on back pain, respiratory distress, and an abnormal mass on chest radiograph. Diagnoses: Computed tomography-guided biopsy confirmed the lung lesion as a metastatic recurrence of high-grade osteosarcoma without local recurrence. Interventions: Chemotherapy was planned, but the patient's general condition rapidly deteriorated and thus palliative therapy was provided. Outcomes: The patient died 2 months after the initial consultation. Lessons: The survival durations of osteosarcoma patients have been prolonged by recent progress in multimodality therapy, and thus clinicians as well as osteosarcoma patients should always keep in mind the possibility of very late relapse.

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Atypical manifestation of lung metastasis 17 years after initial diagnosis of low-grade central osteosarcoma

Cited by 5 publications

References 18 publications

Risk and Prognostic Factors for Different Organ Metastasis in Primary Osteosarcoma: A Large Population‐Based Analysis

Risk and Prognostic Factors for Different Organ Metastasis in Primary Osteosarcoma: A Large Population‐Based Analysis

Identification of a novel iron zinc finger protein 36 (ZFP36) for predicting the overall survival of osteosarcoma based on the Gene Expression Omnibus (GEO) database

Very late relapse of high-grade osteosarcoma

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