Atypical interoception as a common risk factor for psychopathology: A review

Brewer, Rebecca; Murphy, Jennifer; Bird, Geoffrey

doi:10.1016/j.neubiorev.2021.07.036

Cited by 77 publications

(72 citation statements)

References 823 publications

(1,127 reference statements)

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“…This demonstrates a shift in the aIns processing of threat valence with different levels of anxiety, in line with hypothesized differences in brain prediction processing ( Paulus and Stein, 2006 , 2010 ; Paulus et al., 2019 ). In comparison, no anxiety group differences or interactions were found in the breathing prediction error domain, contrasting with some previously proposed hypotheses ( Barrett and Simmons, 2015 ; Brewer et al., 2021 ; Paulus and Stein, 2006 , 2010 ).…”

Section: Discussioncontrasting

confidence: 99%

“…Here, we build on these conceptual advances and assess the relationship between anxiety and breathing-related interoception across the multiple hierarchical levels of processing. Importantly, although many theoretical proposals have been put forward as to how anxiety may interrupt the brain’s processing of dynamic (trial-by-trial) interoceptive predictions and/or prediction errors ( Allen, 2020 ; Barrett and Simmons, 2015 ; Brewer et al., 2021 ; Paulus, 2013 ; Paulus and Stein, 2006 , 2010 ; Paulus et al., 2019 ), these are as yet untested. Therefore, within a rigorous assessment profile, we included neuroimaging of a novel breathing-related interoceptive learning paradigm, providing the first empirical insight into the brain activity associated with interoceptive predictions and prediction errors.…”

Section: Introductionmentioning

confidence: 99%

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Interoception of breathing and its relationship with anxiety

Harrison

Köchli

Marino

et al. 2021

Neuron

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Interoception of breathing and its relationship with anxietyHighlights d A novel trial-by-trial breathing-related interoception task during fMRI at 7 T d Anxiety relates to differences in breathing perception, metacognition, and learning d Anterior insula activity reflects respiratory predictions and prediction errors d Anterior insula activity during interoceptive predictions differs with anxiety

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interoception of breathing and its relationship with anxiety

Harrison

Köchli

Marino

et al. 2021

Neuron

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“…As a first contribution, our results offer a nice framework to study ER strategies and their influence on affective processing, by combining insights from the process model of ER (Gross, 1998;Gross and John, 2003) with others from predictive models of emotion (Seth and Friston, 2016;Barrett, 2017). Second, given the role of altered ER (Cisler et al, 2010) and interoceptive prediction patterns (Brewer et al, 2021) as risk factors for the development of affective psychopathology, our results may provide some potential clinical implications. The assessment of the influence of ER strategies on affective processing through paradigms similar to ours could, for instance, be included among clinical practices to early detect people at risk of psychopathology.…”

Section: Discussionmentioning

confidence: 80%

Emotion regulation strategies differentially modulate neural activity across affective prediction stages: An HD-EEG investigation

Cristaldi

Mento

Buodo

et al. 2022

Front. Behav. Neurosci.

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Emotion regulation (ER) strategies can influence how affective predictions are constructed by the brain (generation stage) to prearrange action (implementation stage) and update internal models according to incoming stimuli (updating stage). However, neurocomputational mechanisms by which this is achieved are unclear. We investigated through high-density EEG if different ER strategies (expressive suppression vs. cognitive reappraisal) predicted event-related potentials (ERPs) and brain source activity across affective prediction stages, as a function of contextual uncertainty. An S1-S2 paradigm with emotional faces and pictures as S1s and S2s was presented to 36 undergraduates. Contextual uncertainty was manipulated across three blocks with 100, 75, or 50% S1-S2 affective congruency. The effects of ER strategies, as assessed through the Emotion Regulation Questionnaire, on ERP and brain source activity were tested for each prediction stage through linear mixed-effects models. No ER strategy affected prediction generation. During implementation, in the 75% block, a higher tendency to suppress emotions predicted higher activity in the left supplementary motor area at 1,500–2,000 ms post-stimulus, and smaller amplitude of the Contingent Negative Variation at 2,000–2,500 ms. During updating, in the 75% block, a higher tendency to cognitively reappraise emotions predicted larger P2, Late Positive Potential, and right orbitofrontal cortex activity. These results suggest that both ER strategies interact with the levels of contextual uncertainty by differently modulating ERPs and source activity, and that different strategies are deployed in a moderately predictive context, supporting the efficient updating of affective predictive models only in the context in which model updating occurs.

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“…Specifically, stroke-induced damage to the insula, compared with damage to other parts of the brain, seems to make it easier for individuals who smoke cigarettes to quit doing so. Poststroke changes in behavior and subjective experience suggest that this effect, which has been replicated in multiple studies (for a review, see Brewer et al, 2021), reflects an abrupt decline in craving caused by a disruption in interoception. For instance, a participant in the seminal study by Naqvi and his colleagues (2007) reported that he quit smoking immediately following a stroke affecting the insula because his “body forgot the urge to smoke” (p. 534).…”

Section: Affect and Interoception Are Key Elements Of Cravingmentioning

confidence: 86%

Constructing Craving: Applying the Theory of Constructed Emotion to Urge States

Wilson

2022

Curr Dir Psychol Sci

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Craving (a strong desire to ingest a substance or engage in an activity) is an important topic of study in the field of psychology. Along with being a key symptom of addiction, craving is a potent source of motivation for a wide range of appetitive behaviors. In this article, I offer a perspective regarding the nature of craving that is rooted in the theory of constructed emotion, a contemporary model of how emotions are created by the brain. According to this perspective, a state of craving emerges when the brain makes predictions that categorize sensory inputs as an instance of craving on the basis of prior experience and the context in which the inputs occur. Using the theory of constructed emotion as a guiding framework, I review various lines of evidence that provide support for this idea. In addition, I offer recommendations for future research that stem from the hypothesis that instances of craving are constructed by the brain in an experience-dependent and situation-specific manner.

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Atypical interoception as a common risk factor for psychopathology: A review

Abstract: Graphical abstract

Cited by 77 publications

References 823 publications

Interoception of breathing and its relationship with anxiety

Interoception of breathing and its relationship with anxiety

Emotion regulation strategies differentially modulate neural activity across affective prediction stages: An HD-EEG investigation

Constructing Craving: Applying the Theory of Constructed Emotion to Urge States

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