Atypical herpes simplex keratitis: frequency, clinical presentations and treatment results

Erdem, Elif; Harbiyeli, İbrahim İnan; Öztürk, Gökhan; Oruz, Oğuzhan; Acikalin, Arbil; Yaǵmur, Meltem; Ersöz, Reha; Yarkın, Fügen

doi:10.1007/s10792-019-01226-1

Cited by 17 publications

(18 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Herpes simplex has been responsible for 2 types of disease, including blepharitis in the context of the primary infection of this virus and keratitis. These results can be superimposed on those of the literature [5,9,12].…”

Section: Discussionmentioning

confidence: 56%

“…Herpes zoster has been responsible for 3 types of disease, namely, ophthalmic shingles, keratitis, and acute hypertensive anterior uveitis. It is recognized that ophthalmic shingles is often the inaugural disease of HIV/AIDS [4,9,10]. However, no direct link has yet been demonstrated between HIV-related immunosuppression and the 2 other pathologies due to Herpes zoster, notably keratitis and acute hypertensive anterior uveitis [4,11].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2019

JOCR

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Untitled

2019

JOCR

View full text Add to dashboard Cite

“…Herpetic keratitis is a rare occurrence following intravitreal and subconjunctival injection of bevacizumab. [2][3][4] Khalili et al reported occurrence of herpetic epithelial keratitis following intravitreal injection of bevacizumab for proliferative diabetic retinopathy. 2 Derham et al have described a case of bilateral herpetic keratitis following bilateral intravitreal bevacizumab injection for exudative age related macular degeneration and associated diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Though our case did not present with a typical dendritic pattern, based on initial response to antiviral medications and progression to a typical geographic ulcer on instillation of mild steroid, we made a clinical diagnosis of atypical herpetic ulcer. 4 Erdem et al successfully treated 72% of atypical ulcers with antiviral drugs and isolated herpes simplex virus(HSV) DNA in only 9% of cases. 4 The presence of latent herpes in trigeminal ganglia has been found to increase with increasing age.…”

Section: Discussionmentioning

confidence: 99%

Meta-herpetic ulcer following intravitreal bevacizumab

Behera

Gokhale

Deb

et al. 2020

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: To report a case of meta-herpetic ulcer that developed after intravitreal bevacizumab injection. Methods: A 55-year-old man with type 2 diabetes mellitus and nephropathy received intravitreal injection of bevacizumab in his right eye for proliferative diabetic retinopathy with macular edema. Results: Two days after the injection, the patient presented with severe pain, redness, and photophobia, and decreased visual acuity in the right eye. The cornea showed a paracentral epithelial erosion with heaped margins with subepithelial haze and punctate keratopathy, and high intraocular pressure. He initially responded to topical antiviral and antiglaucoma medications. However, it rapidly progressed to a geographic ulcer on initiation of mild steroid and became resistant to conventional medical management. His nephropathy precluded treatment with full dose of systemic antivirals and antiglaucoma drugs. Subsequently, it healed after a paramedian tarsorrhaphy was performed. Conclusion: Herpetic epithelial keratitis following intravitreal bevacizumab is a rare occurence. However, this case is the first report of progression to a meta-herpetic ulcer.

show abstract

“…With over a billion individuals worldwide currently infected with herpes simplex virus type 1 (HSV-1), herpes remains one of the most prevalent viral eye infections (1)(2)(3). Ocular herpes is mainly caused by HSV-1, which infects the cornea and then establishes latency in sensory neurons of the trigeminal ganglia (TG).…”

Section: Introductionmentioning

confidence: 99%

Antiviral CD19⁺CD27⁺ Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpes Infection

Dhanushkodi

Prakash

Srivastava

et al. 2021

Preprint

View full text Add to dashboard Cite

Reactivation of herpes simplex virus 1 (HSV-1) from latently infected neurons of the trigeminal ganglia (TG) leads to blinding recurrent herpetic disease in symptomatic (SYMP) individuals. Although the role of T cells in herpes immunity seen in asymptomatic (ASYMP) individuals is heavily explored, the role of B cells is less investigated. In the present study, we evaluated whether B cells are associated with protective immunity against recurrent ocular herpes. The frequencies of circulating HSV-specific memory B cells and of memory follicular helper Tcells (CD4+ Tfh cells), that help B cells produce antibodies, were compared between HSV-1 infected SYMP and ASYMP individuals. The levels of IgG/IgA and neutralizing antibodies were compared in SYMP and ASYMP individuals. We found that: (i) the ASYMP individuals had increased frequencies of HSV-specific CD19+CD27+ memory B cells; and (ii) high frequencies of HSV-specific switched IgG+CD19+CD27+ memory B cells detected in ASYMP individuals were directly proportional to high frequencies of CD45R0+CXCR5+CD4+ memory Tfh cells. However, no differences were detected in the level of HSV-specific IgG/IgA antibodies in SYMP and ASYMP individuals. Using the UV-B-induced HSV-1 reactivation mouse model, we found increased frequencies of HSV-specific antibody-secreting plasma HSV-1 gD+CD138+ B cells within the TG and circulation of ASYMP mice compared to SYMP mice. In contrast, no significant differences in the frequencies of B cells were found in the cornea, spleen, and bone-marrow. Our findings suggest that circulating antibody-producing HSV-specific memory B cells recruited locally to the TG may contribute to protection from symptomatic recurrent ocular herpes.

show abstract

Atypical herpes simplex keratitis: frequency, clinical presentations and treatment results

Cited by 17 publications

References 19 publications

Untitled

Untitled

Meta-herpetic ulcer following intravitreal bevacizumab

Antiviral CD19⁺CD27⁺ Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpes Infection

Contact Info

Product

Resources

About

Atypical herpes simplex keratitis: frequency, clinical presentations and treatment results

Cited by 17 publications

References 19 publications

Untitled

Untitled

Meta-herpetic ulcer following intravitreal bevacizumab

Antiviral CD19+CD27+ Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpes Infection

Contact Info

Product

Resources

About

Antiviral CD19⁺CD27⁺ Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpes Infection