Atypical Hemolytic Anemia

The Survival of Transfused Red Cells in Acute Rheumatic Fever with Reference to a Latent Haemolytic Mechanism

“…This abnormal destruction of donor cells may occur either in a linear fashion (Mollison, 1947) or by means of a curvilinear slope of elimination indicating random destruction of cells irrespective of their age (Brown et al, 1944); the latter appears to be by far the more common finding in such cases. Such results have been reported by many authorities (Young and Lawrence, 1946;Mollison, 1947;Selwyn and Hackett, 1949;Brown, 1950), and the value of transfused red cell survival experiments in the evaluation of haemolytic mechanisms is now generally recognized.…”

“…Thus the slope of elimination is linear (Mollison. 1947) (Young and Lawrence, 1946), while others estimate the time after transfusion at which 50% survival occurs (Berlin, 1951). In expressing results in these cases of acute rheumatic fever, where the greatest activity of the disease occurred in the first 20 to 30 days after transfusion, the percentage survival at 10 and 20 days after transfusion seems most likely to give the maximum information.…”

“…Analysis of Material The results in acute rheumatic fever are compared N \ below with the normal findings in the six cases in this control series and with the normal controls in N the series of Mollison (1947) and of Callender et al iD.. \s (1945) in adults, and that of Kaplan and Zuelzer \ "K. (1950) (Young and Lawrence, 1946), while others estimate the time after transfusion at which 50% survival occurs (Berlin, 1951). In expressing results in these cases of acute rheumatic fever, where the greatest activity of the disease occurred in the first 20 to 30 days after transfusion, the percentage survival at 10 and 20 days after transfusion seems most likely to give the maximum information.…”

“…The normal mean cell life of 100 to 120 days, determined by this method, correlates well with that found by estimating the survival of the subject's own cells in his circulation by tagging them with N16 labelled glycine (Shemin and Rittenberg, 1946). The Ashby technique with its recent modifications is now widely accepted as a useful method for studying haemolytic mechanistns (Brown et al, 1944;Berlin, 1951;Mollison, 1947;Young and Lawrence, 1946). Method The survival of transfused red cells was estimated by Dacie and Mollison's (1943) modification of the Ashby technique.…”

Acute Idiopathic Haemolytic Anaemia

“…The association of auto-agglutination at 37°C, haemolytic anaeia, and multiple thromboses in 18 superficial leg veins and splenic vessels was noted by Young and Lawrence (1946) and by Renner (1947).…”