Atypical hatching of a cow blastocyst leading to separation of complete twin half blastocysts

Massip, A.; Zwalmen, P. Van Der; Mulnard, Jacques; Zwijsen, W

doi:10.1136/vr.112.13.301

Cited by 25 publications

(6 citation statements)

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“…Massip et al (1983) reported "a few monozygotic twins out of 500 embryo transfers in Canada." This is much higher than the natural occurrence and suggests that the procedures of embryo transfer could cause a higher incidence of monozygotic twinning.…”

Section: Discussionmentioning

confidence: 97%

“…During this same time period, the inner cell mass acquires its future anteroposterior polarity (Noden and De Lahunta, 1985). Massip et al (1983) have shown via time-lapse cinematography that bovine embryos emerge from their zona pellucidas by a rapid and smooth process of herniation through a slit (Fig. 9A).…”

Section: Discussionmentioning

confidence: 99%

“…The natural occurrence of monozygotic twins in cattle is approximately 0.1% of all births, or about 10% of all same-sexed twins (McGeady et al, 1979). Massip et al (1983) reported "a few monozygotic twins out of 500 embryo transfers in Canada." This is much higher than the natural occurrence and suggests that the procedures of embryo transfer could cause a higher incidence of monozygotic twinning.…”

Section: Discussionmentioning

confidence: 99%

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Two‐headed, two‐necked conjoined twin calf with partial duplication of thoracoabdominal structures: Role of blastocyst hatching

1987

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Gross anatomical analysis of a derodidymic monosomic stillborn male calf from an embryo transfer recipient was carried out. Two normal heads were present on two necks which were fused at the shoulders. Although the ribs were abnormal in shape and number, there was one trunk and four legs. The vertebrae were double and partially fused from the thoracic region to the sacrum, which was singular and normal. In the thoracic region there was a single vertebral canal that contained two incompletely fused spinal cords which shared common meninges. In the lumbar region there was a spina bifida. The medial neck musculature was variously fused. Two esophagi entered one enlarged rumen and the liver and gallbladder had extra lobes. Two sets of lungs occupied three pleural cavities and also part of the pericardial cavity. Two hearts were joined by a common cavernous venous sinous. The vasculature cranial to the heart reflected the doubling. The vasculature caudally was singular. The calf was uniscrotal and ipsilaterally cryptorchid. Our results are consistent with the hypothesis that atypical "hatching," that is, emergence of the blastocyst from the zona pellucida, may cause anomalous twinning.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Two‐headed, two‐necked conjoined twin calf with partial duplication of thoracoabdominal structures: Role of blastocyst hatching

1987

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“…Some of the reports are case studies, 8,30 another is a prospective cohort study involving too small a sample size to reach statistical significance 12 . Artificially induced or naturally occurring structural features of the zona pellucida may be associated with inner cell mass splitting during hatching resulting in monozygotic twinning as previously described in animal models 31–34 . Similar processes may occur in the human embryo 35 .…”

Section: Assisted Reproductive Technologiesmentioning

confidence: 95%

Is there increased monozygotic twinning after assisted reproductive technology?

Toledo

2005

Aust NZ J Obst Gynaeco

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Over the past two decades there has been an association between assisted reproductive technologies and increased monozygotic twinning. The association is not clear nor are the causes of assisted reproductive technology-related monozygotic twinning understood, although there are several theories as to the possible mechanisms involved. This review looks at some of the assisted reproductive technologies which may be associated with an increased risk of monozygotic twinning such as intracytoplasmic sperm injection, assisted hatching and blastocyst transfers. Determining the true incidence of monozygotic twinning after assisted reproductive technologies is important as there is a well-documented increase in perinatal morbidity and mortality of monozygotic twins compared to singleton and dizygotic pregnancies.

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“…Surprisingly, after assisted reproductive help, monochorionic, even monoamnionic multiple pregnancies have repeatedly been reported, by Edwards et al ( 1986 ) and by Salat-Baroux et al ( 1994 ) . Massip et al ( 1983 ) observed cinematographically the atypical hatching of a cow blastocyst in vitro and suggested that it may be the mechanism by which dichorionic MZ twins take their origin. They observed partial protrusion of blastomeres from a zona, and after the "hatching" was complete, the two cell masses were connected only by a diminutive bridge.…”

Section: Causes Of Multiple Births and Incidencementioning

confidence: 96%