2013
DOI: 10.1007/s00402-013-1760-3
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Atypical forearm fractures associated with long-term use of bisphosphonate

Abstract: Recent reports on atypical femoral fracture have raised concerns about the long-term use of bisphosphonate. More recent case series focus specifically on the subtrochanteric fractures. But, there is relatively rarity and unawareness of atypical fracture in upper extremity. We report forearm fracture in two women receiving long-term bisphosphonate therapy. First woman presented with pain in the forearm and both thighs and radiographs showed incomplete fractures in a proximal ulnar shaft and bilateral femoral sh… Show more

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Cited by 28 publications
(13 citation statements)
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“…Four patients have been treated conservatively [4, 6, 10, 13], and four others had fractures fixed with a plate and a bone graft [5, 7, 12]. Four of five fractures treated by internal rigid fixation [3, 8, 9, 11] united uneventfully, and complications developed in one patient during the healing process.…”
Section: Discussionmentioning
confidence: 99%
“…Four patients have been treated conservatively [4, 6, 10, 13], and four others had fractures fixed with a plate and a bone graft [5, 7, 12]. Four of five fractures treated by internal rigid fixation [3, 8, 9, 11] united uneventfully, and complications developed in one patient during the healing process.…”
Section: Discussionmentioning
confidence: 99%
“…Second, fracture union cannot be achieved or delayed. If the patient is still on bisphosphonate therapy, it should be immediately stopped; thus bisphosphonates accumulation on fracture surface had been prevented to break the resistance to fracture site resorption [1013]. Early diagnosis of undisplaced occult fractures is crucial and prophylactic surgical fixation is recommended due to difficulties in fracture site fixation.…”
Section: Discussionmentioning
confidence: 99%
“…She was treated with a long-arm cast. Both women did not receive pharmacologic supplementation, yet both also had an uneventful course of healing 5 .…”
Section: Discussionmentioning
confidence: 99%