Atypical features in pleomorphic adenoma—a clinicopathologic study and implications for management

Ethunandan, M.; Witton, Robert; Hoffman, Gary R.; Spedding, Anne V.; Brennan, Peter A.

doi:10.1016/j.ijom.2006.02.009

Cited by 55 publications

(46 citation statements)

References 24 publications

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“…The typical signs and symptoms of malignancy, such as rapid growth, facial palsy, pain, and enlarged lymph nodes are present in only 10-35 % of salivary gland carcinomas [5]. Majority of cancers have unremarkable features and are indistinguishable from benign salivary gland neoplasms on clinical criteria alone, as was observed in both of our cases.…”

Section: Discussionsupporting

confidence: 71%

Salivary Gland Tumors: A Diagnostic Dilemma!

Peravali

Bhat

Upadya

et al. 2014

J. Maxillofac. Oral Surg.

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Salivary gland tumors generate considerable interest because of their heterogeneous and variable histology, grade of malignancy, and clinical behavior. Fine needle aspiration cytology (FNAC) is considered the first diagnostic modality for salivary neoplasms due to its ready availability and ease of performance. However it cannot always be relied upon in isolation, and should be used in conjunction with other investigations like incisional biopsy. We present two cases, which highlight the drawbacks of relying on FNAC alone, which resulted in misdiagnosis of adenoid cystic carcinoma as pleomorphic adenoma.

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Section: Discussionsupporting

confidence: 71%

Salivary Gland Tumors: A Diagnostic Dilemma!

Peravali

Bhat

Upadya

et al. 2014

J. Maxillofac. Oral Surg.

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“…In addition, it has been well documented that pleomorphic adenoma, which is classified as benign tumor, is aneuploid, and invades normal adjacent tissue and metastasize at distant sites after certain period of time. 7 While benign tumors are of pleomorphic and Warthin's tumors, the malignant tumors are classified as mucoepidermoid, adenoid cystic, acinic cell, clear cell, basal cell carcinoma, adenocarcinoma not otherwise mentioned (NOS), squamous cell carcinoma, salivary duct carcinoma, myoepithelial carcinoma and polymorphous low grade adenocarcinoma based on their origin. 8,9 Such morphological and biological diversity of SGT, makes it more challenging to diagnose and classify these tumors.…”

Section: Introductionmentioning

confidence: 99%

Sperm associated antigen 9(SPAG9) expression and humoral response in benign and malignant salivary gland tumors

et al. 2014

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Keywords: biomarker, cancer testis antigen, early detection and diagnosis, immunotherapeutic target, SPAG9Salivary gland cancers are highly aggressive epithelial tumor associated with metastatic potential and high mortality. The tumors are biologically diverse and are of various histotypes. Besides, the detection and diagnosis is a major problem of salivary gland cancer for available treatment modalities. In the present study, we have investigated the association of sperm associated antigen 9 (SPAG9) expression with salivary gland tumor (SGT). Clinical specimens of benign (n D 16) and malignant tumors (n D 86) were examined for the SPAG9 expression. In addition, the sera and adjacent non-cancerous tissues (n D 72) from available patients were obtained. Our in situ RNA hybridization and immunohistochemistry (IHC) analysis revealed significant difference (p D 0.0001) in SPAG9 gene and protein expression in benign (63%) and malignant tumor (84%) specimens. Further, significant association was also observed between SPAG9 expression and malignant tumors (P D 0.05). A cut-off value of >10% cells expressing SPAG9 protein designated as positive in IHC, predicted presence of malignant SGT with 83.72% sensitivity, 100% specificity, 100% PPV and 83.72% NPV. Humoral response against SPAG9 protein was generated in 68% of SGT patients. A cut-off value of 0.212 OD for anti-SPAG9 antibodies in ELISA predicted presence of malignant SGT with 69.23% sensitivity, 100% specificity, 100% PPV and 78.94% NPV. Collectively, our data suggests that the majority of SGT show significant difference and association among benign and malignant tumors for SPAG9 gene and protein expression and also exhibit humoral response against SPAG9 protein. Hence, SPAG9 may be developed as a biomarker for detection and diagnosis of salivary gland tumors.

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“…Pour notre observation dʼAP parapharyngé lʼIRM a permis de visualiser ce liséré graisseux. Lʼadénome pléomorphe nʼest pas une tumeur maligne mais elle a une tendance vers la récidive (18). Une exé-rèse tumorale large avec 5 mm de marge en tissu sain est le traitement de choix quelque soit la localisation tumorale (19,20).…”

Section: Discussionunclassified