Atypical exocrine and endocrine pancreatic tumors (anaplastic, small cell, and giant cell types): CT and pathologic features in 14 patients

Ichikawa, Tomoya; Federle, Michael P.; Ohba, Satoru; Ohtomo, Kuni; Sugiyama, Akiko; Fujimoto, Hajime; Haradome, Hiroki; Araki, Tsutomu

doi:10.1007/s002610000058

Cited by 66 publications

(51 citation statements)

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“…PNEN shows varied enhancement on dynamic CT. [17][18][19][20][21]30 As shown in Figure 1A, tumors with typical findings are easy to diagnose, but some neoplasms cannot be differentiated from pancreatic adenocarcinomas. 31 Therefore, the diagnostic accuracy of dynamic CT is insufficient, with 64-81% of sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19][20] Inversely, it is reported that characteristic finding of small cell cancer of pancreas takes on a slight enhanced effect with CT using contrast agent. 21 However, there is no detailed report about the correlation between pathological grade based on WHO2010 and quantitative evaluation of the enhancement on enhanced CT.…”

Section: X190mm (96 X 96 Dpi)mentioning

confidence: 99%

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Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm

Horiguchi

Kato

Shiraha

et al. 2017

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Section: X190mm (96 X 96 Dpi)mentioning

confidence: 99%

Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm

Horiguchi

Kato

Shiraha

et al. 2017

J of Gastro and Hepatol

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“…CT depicts this neoplasm as large thick-walled cystic masses with a ragged inner contour, due to central hemorrhagic necrosis. Otherwise, solid masses with a relatively low attenuation center are found [10][11]. No distinctive CT features that allow the differentiation from ductal adenocarcinoma have been reported.…”

Section: Pleomorphic Giant Cell Carcinomamentioning

confidence: 99%

CT in the Differentiation of Pancreatic Neoplasms – Progress Report

Gritzmann

Macheiner²,

Hollerweger³

et al. 2004

Dig Dis

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Today, computed tomography (CT) is the most commonly used imaging method in the assessment of pancreatic tumors. The sensitivity of CT in detection of pancreatic tumors is more than 90% when direct and indirect signs are used for diagnosis. However, the potential to differentiate exocrine (non-endocrine) tumors of the pancreas is limited. CT is used in these lesions to perform an adequate staging, especially for surgical purposes. The operative resectability, primarily in regard to vessels, lymph node metastasis and hepatic metastasis, has to be assessed. Keeping in mind the limitations of this macromorphological imaging procedure, CT has the best reproducibility and overall accuracy of all imaging methods. Using multislice CT it is possible to perform non-axial reconstructions with high resolution. In functional endocrine tumors, multislice spiral CT will enhance the diagnostic capabilities, since the whole organ can be examined in thin slices, with high resolution during the rather short arterial phase of the contrast medium. Since some endocrine tumors are hypovascular, a scan during the portovenous phase is recommended too. The diagnosis of benign pancreatic tumors, like serous cystadenoma and pancreatic lipomas, is addressed. The most important pseudotumors of the pancreas are discussed.

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“…Undifferentiated carcinoma of the pancreas is a rare and aggressive tumor; accounts for 2-7% of all pancreatic cancers (1)(2)(3)(4). The prognosis of undifferentiated carcinoma of the pancreas is worse than that of poorly differentiated ductal adenocarcinoma of the pancreas (5).…”

Section: Introductionmentioning

confidence: 99%

Effective Use of Gemcitabine in the Treatment of Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas with Portal Vein Tumor Thrombus

et al. 2012

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A 74-year-old woman had an undifferentiated carcinoma with osteoclast-like giant cells (UCWOGC) in the body of the pancreas with massive portal vein tumor thrombus (PVTT). Because the PVTT progressed so rapidly into the right portal branch, the patient first underwent distal pancreatectomy and tumor thrombectomy to prevent life-threatening portal venous obstruction. Although a recurrent PVTT had developed early postoperatively, systemic gemcitabine treatment was so effective that it induced complete remission 5 months after the initiation of chemotherapy. The patient continued to be in complete response for 12 months, and has survived for 19 months since surgery.

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Atypical exocrine and endocrine pancreatic tumors (anaplastic, small cell, and giant cell types): CT and pathologic features in 14 patients

Abstract: Although a specific diagnosis may not be possible in some cases, we believe that knowledge of certain pathologic and computed tomographic features should lead to optimal diagnosis, therapy, and prognosis.

Cited by 66 publications

References 0 publications

Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm

Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm

CT in the Differentiation of Pancreatic Neoplasms – Progress Report

Effective Use of Gemcitabine in the Treatment of Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas with Portal Vein Tumor Thrombus

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