Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition

Hale, Georgina E.; Hughes, Claude L.; Burger, Henry G.; Robertson, David; Fraser, Ian S.

doi:10.1097/gme.0b013e31817ee0c2

Cited by 106 publications

(89 citation statements)

References 42 publications

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“…The marked increase in estradiol levels during the early follicular phase demonstrating the low ovarian reserve is due to luteal out-of-phase events and appears to be triggered by prolonged high FSH levels during the follicular phase. 13 …”

Section: Discussionmentioning

confidence: 99%

Subclinical Impairment of Ovarian Reserve in Systemic Lupus Erythematosus Patients with Normal Menstruation Not Using Alkylating Therapy

Zhan

Liang

et al. 2013

Journal of Women's Health

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Background: Disease activity is a major factor in menstrual disorders in systemic lupus erythematosus (SLE) patients not receiving alkylating therapy. However, the ovarian reserve of SLE women with normal menstruation is still unclear. Methods: Twenty-three SLE patients naïve to cytotoxic agents (SLE group) and nineteen SLE patients receiving current or previous cyclophosphamide (CTX) therapy (without other cytotoxic agents; SLE-CTX group) were enrolled. Twenty-one age-matched healthy women served as controls. All patients and controls had a regular menstrual cycle. Basal hormone levels, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E 2 ), and anti-Mü llerian hormone (AMH), and antral follicle count (AFC) were analyzed in the two study groups and compared with the control group. Results: No significant differences were found between the SLE, SLE-CTX, and control groups in age, body mass index (BMI), and basal FSH and LH levels. The E 2 (P = 0.023) levels were high and the AMH (P = 0.000) values and AFC (P = 0.001) were significantly lower in the SLE and SLE-CTX groups compared to control. However, these values were similar between the SLE and SLE-CTX groups. Conclusion: SLE patients not receiving alkylating therapy who had normal menstruation and short illness duration still had an impaired ovarian reserve.

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Section: Discussionmentioning

confidence: 99%

Subclinical Impairment of Ovarian Reserve in Systemic Lupus Erythematosus Patients with Normal Menstruation Not Using Alkylating Therapy

Zhan

Liang

et al. 2013

Journal of Women's Health

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“…One of them was characterized by high FSH levels, which has been associated with a slow decline in estradiol levels. 17 Similarly, Hale et al 18 reported that in 37% of the Caucasian women with menopausal owing to the loss of endogenous ovarian hormone production.…”

Section: Resultsmentioning

confidence: 99%

“…High estradiol levels with the onset of the menopausal transition could be related to a decrease in the number of ovarian follicles and the resultant impairment of a negative feedback causing elevation in FSH levels. 18,19 Another possibility is that the hypothalamic-pituitary-adrenal axis becomes less sensitive to estrogen during perimenopause.…”

Section: 21mentioning

confidence: 99%

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Nutritional habits and oxidative stress in postmenopausal age

Grygiel-Górniak¹,

Justyna²,

Szczepanik³

et al. 2014

Polish Archives of Internal Medicine

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“…Hale and coauthors estimated that about a third of all menopausal transition cycles show evidence of these events, with a higher estradiol peak following the normal mid-cycle estradiol peak [4,12].…”

Section: Inaccurate Estrogen Levelsmentioning

confidence: 99%

Reproductive Aging: Perimenopause and Psychopathological Symptoms

Geršak¹,

Gersak²,

Turčin³

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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The female reproductive axis essentially comprises of the hypothalamic-pituitaryovarian axis and the mullerian-derived structures. The reproductive axis ages to a nonfunctional state (menopause) much earlier than the other organ systems do, at a time when a woman is otherwise healthy. The basis of reproductive senescence in women is oocyte depletion in the ovary. Perimenopause is defined by menstrual cycle and endocrine changes, such as disturbed ovarian-pituitary-hypothalamic feedback relationships, inaccurate estrogen levels, and decreased progesterone levels. Many psychopathological changes can take place, but most commonly women experience mild cognitive impairment, anxiety, irritability, mood swings, and depression. Estrogens influence depression and depressive-like behavior through interactions with neurotropic factors and through an influence on the serotonergic system.

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Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition

Abstract: Many of the marked increases in ovulatory cycle E2 and cycle irregularities during the menopausal transition may be due to LOOP events and appear to be triggered by prolonged high follicular phase follicle-stimulating hormone levels.

Cited by 106 publications

References 42 publications

Subclinical Impairment of Ovarian Reserve in Systemic Lupus Erythematosus Patients with Normal Menstruation Not Using Alkylating Therapy

Subclinical Impairment of Ovarian Reserve in Systemic Lupus Erythematosus Patients with Normal Menstruation Not Using Alkylating Therapy

Nutritional habits and oxidative stress in postmenopausal age

Reproductive Aging: Perimenopause and Psychopathological Symptoms

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