Atypical Diabetes and Management Considerations

Patil, Shivajirao P.

doi:10.1016/j.pop.2021.11.003

Cited by 3 publications

(2 citation statements)

References 71 publications

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“…As a result, they have characteristics of both T1DM and T2DM and are at risk of being misdiagnosed as having T2DM[ 18 ]. According to studies from China, Korea, India, and the United Arab Emirates, the prevalence of LADA is 5.7%, 4.4% to 5.3%, 2.6% to 3.2%, and 2.6%, respectively[ 19 ]. Usage of clinical risk tools (age of onset of diabetes < 50 years, acute symptoms of hyperglycemia at the time of onset, body mass index < 25 kg/m 2 , family history or personal history of autoimmune disease), and evaluation of C-peptide level can help identify individuals at higher risk of LADA in adults[ 19 ].…”

Section: Atypical Diabetes Mellitusmentioning

confidence: 99%

Genetics of diabetes

Goyal¹,

Rani²,

Bhat³

et al. 2023

World J Diabetes

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Diabetes mellitus is a complicated disease characterized by a complex interplay of genetic, epigenetic, and environmental variables. It is one of the world's fastest-growing diseases, with 783 million adults expected to be affected by 2045. Devastating macrovascular consequences (cerebrovascular disease, cardiovascular disease, and peripheral vascular disease) and microvascular complications (like retinopathy, nephropathy, and neuropathy) increase mortality, blindness, kidney failure, and overall quality of life in individuals with diabetes. Clinical risk factors and glycemic management alone cannot predict the development of vascular problems; multiple genetic investigations have revealed a clear hereditary component to both diabetes and its related complications. In the twenty-first century, technological advancements (genome-wide association studies, next-generation sequencing, and exome-sequencing) have led to the identification of genetic variants associated with diabetes, however, these variants can only explain a small proportion of the total heritability of the condition. In this review, we address some of the likely explanations for this "missing heritability", for diabetes such as the significance of uncommon variants, gene-environment interactions, and epigenetics. Current discoveries clinical value, management of diabetes, and future research directions are also discussed.

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Section: Atypical Diabetes Mellitusmentioning

confidence: 99%

Genetics of diabetes

Goyal¹,

Rani²,

Bhat³

et al. 2023

World J Diabetes

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show abstract

“…Diabetes mellitus is a group of physiological dysfunctions characterized by a hypoglycemic state, insulin deficiency, inadequate insulin secretion, or excessive glucagon secretion [ 27 ]. The World Health Organization (WHO), along with the American Diabetes Association (ADA), identified four types of diabetes mellitus: type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), “other specific types”, and gestational diabetes [ 28 , 29 ], wherein T1DM and T2DM are the prominent ones, and among them, the latter is predominant. In simple terms, T1DM primarily involves autoimmune insulin deficiency, whereas T2DM is contributed to by the pathological state of insulin deficiency and insulin resistance [ 27 ].…”

Section: Role Of Tea Plant and Related Compounds In Diabetes Mellitusmentioning

confidence: 99%

Tea Plant (Camellia sinensis): A Current Update on Use in Diabetes, Obesity, and Cardiovascular Disease

et al. 2022

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The tea plant (C. sinensis) has traditionally been consumed worldwide as “tea” for its many health benefits, with the potential for the prevention and therapy of various conditions. Regardless of its long history, the use of tea plants in modern times seems not to have changed much, as the beverage remains the most popular form. This review aimed to compile scientific information about the role and action of tea plants, as well as their status concerning clinical applications, based on the currently available evidence, with a focus on metabolic syndrome, mainly covering obesity, diabetes, and cardiovascular disease. It has been recognized that these diseases pose a significant threat to public health, and the development of effective treatment and prevention strategies is necessary but still challenging. In this article, the potential benefits of tea plants and their derived bioactive components (such as epigallocatechin-3-gallate) as anti-obesity, anti-diabetic, and anti-cardiovascular agents are clearly shown and emphasized, along with their mechanisms of action. However, according to the status of the clinical translation of tea plants, particularly in drug development, more substantial efforts in well-designed, randomized, controlled trials are required to expand their applications in treating the three major metabolic disorders and avoiding the toxicity caused by overconsumption.

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Missed Opportunities in Type 2 Diabetes Mellitus: A Narrative Review

Kwok,

Phillips,

Mukherjee

et al. 2024

CDR

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Background: Type 2 diabetes mellitus (T2DM) is a significant health problem around the world. Objective: This review aims to define missed opportunities and how they apply to patients with T2DM. Method: This narrative review describes the natural history of T2DM and also describes where missed opportunities may arise. Results: Missed opportunities may relate to prevention, early detection, diagnosis, and treatment of diabetes. The cornerstone of T2DM prevention is the control of modifiable risk factors and lifestyle changes to potentially prevent diabetes. Early detection of T2DM is important as it is a chronic condition that can progress rapidly if untreated. Missed opportunities related to the diagnosis of T2DM draw attention to the heterogeneous presentation of diabetes. The condition can be incidentally identified in asymptomatic patients, so all healthcare professionals should be aware of the disease. Furthermore, it is not unexpected that patients with atypical symptoms may have a delay in diagnosis. The treatment-related missed opportunities in T2DM are broad and include self-care, education, remission of T2DM, risk factor management, prevention of complications, medication therapy and compliance, as well as individualized care. Considering patient pathways is a useful approach to evaluate missed opportunities in patient care. Conclusion: Missed opportunities are a concept that is not often considered in diabetes care, which calls upon reflection of real-world activities and consideration of whether patient outcomes could have been improved with changes in decision-making. Future studies that aim to improve patient care should consider this concept.

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Atypical Diabetes and Management Considerations

Cited by 3 publications

References 71 publications

Genetics of diabetes

Genetics of diabetes

Tea Plant (Camellia sinensis): A Current Update on Use in Diabetes, Obesity, and Cardiovascular Disease

Missed Opportunities in Type 2 Diabetes Mellitus: A Narrative Review

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