Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study

Chiang, Hung‐Lung; Tseng, Wen‐Yih Isaac; Tseng, Wan‐Ling; Tung, Yung-Liang; Hsu, Ying Shao; Chen, Changle; Gau, Susan Shur‐Fen

doi:10.1016/j.ajp.2022.103358

Cited by 8 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data indicate that the maturational profile of sensorimotor microstructure (more specifically, the bilateral CST) from late childhood into adolescence, may offer insight into the presence of motor difficulties in a sub‐set of adolescents with ADHD. Though recent work has mapped the development of microstructure of the CST in those with ADHD (Chiang et al, 2023 ), it did not evaluate its impact on functional motor outcomes. Thus, the degree to which microstructure of the CST, and its maturational profile, might distinguish those with ADHD who present with motor problems from those who do not was unclear.…”

Section: Discussionmentioning

confidence: 99%

Adolescents with ADHD and co‐occurring motor difficulties show a distinct pattern of maturation within the corticospinal tract from those without: A longitudinal fixel‐based study

Hyde,

Fuelscher,

Efron

et al. 2023

Human Brain Mapping

View full text Add to dashboard Cite

It is well documented that attention‐deficit hyperactivity disorder (ADHD) often presents with co‐occurring motor difficulties. However, little is known about the biological mechanisms that explain compromised motor skills in approximately half of those with ADHD. To provide insight into the neurobiological basis of poor motor outcomes in ADHD, this study profiled the development of white matter organization within the cortico‐spinal tract (CST) in adolescents with ADHD with and without co‐occurring motor problems, as well as non‐ADHD control children with and without motor problems. Participants were 60 children aged 9–14 years, 27 with a history of ADHD and 33 controls. All underwent high‐angular resolution diffusion MRI data at up to three time points (115 in scans total). We screened for motor impairment in all participants at the third time point (≈14 years) using the Developmental Coordination Disorder Questionnaire (DCD‐Q). Following pre‐processing of diffusion MRI scans, fixel‐based analysis was performed, and the bilateral CST was delineated using TractSeg. Mean fiber density (FD) and fiber cross‐section (FC) were extracted for each tract at each time‐point. To investigate longitudinal trajectories of fiber development, linear mixed models were performed separately for the left and right CST, controlling for nuisance variables. To examine possible variations in fiber development between groups, we tested whether the inclusion of group and the interaction between age and group improved model fit. At ≈10 years, those with ADHD presented with lower FD within the bilateral CST relative to controls, irrespective of their prospective motor status. While these microstructural abnormalities persisted into adolescence for individuals with ADHD and co‐occurring motor problems, they resolved for those with ADHD alone. Divergent maturational pathways of motor networks (i.e., the CST) may, at least partly, explain motor problems individuals with ADHD.

show abstract

Section: Discussionmentioning

confidence: 99%

Adolescents with ADHD and co‐occurring motor difficulties show a distinct pattern of maturation within the corticospinal tract from those without: A longitudinal fixel‐based study

Hyde,

Fuelscher,

Efron

et al. 2023

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…With the improvement in DSI data acquisition, more attention has recently been paid to its application in clinical diseases, including attention-deficit/hyperactivity disorder (ADHD) [2,64,65], schizophrenia [66][67][68], stroke [69][70][71][72], Parkinson's disease [73,74], hypertension [75], autism [76], epilepsy [77], and gliomas [78] (see Table 2).…”

Section: Clinical Applicationsmentioning

confidence: 99%

Research Progress in Diffusion Spectrum Imaging

Sun,

Huang,

Wang

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

Studies have demonstrated that many regions in the human brain include multidirectional fiber tracts, in which the diffusion of water molecules within image voxels does not follow a Gaussian distribution. Therefore, the conventional diffusion tensor imaging (DTI) that hypothesizes a single fiber orientation within a voxel is intrinsically incapable of revealing the complex microstructures of brain tissues. Diffusion spectrum imaging (DSI) employs a pulse sequence with different b-values along multiple gradient directions to sample the diffusion information of water molecules in the entire q-space and then quantitatively estimates the diffusion profile using a probability density function with a high angular resolution. Studies have suggested that DSI can reliably observe the multidirectional fibers within each voxel and allow fiber tracking along different directions, which can improve fiber reconstruction reflecting the true but complicated brain structures that were not observed in the previous DTI studies. Moreover, with increasing angular resolution, DSI is able to reveal new neuroimaging biomarkers used for disease diagnosis and the prediction of disorder progression. However, so far, this method has not been used widely in clinical studies, due to its overly long scanning time and difficult post-processing. Within this context, the current paper aims to conduct a comprehensive review of DSI research, including the fundamental principles, methodology, and application progress of DSI tractography. By summarizing the DSI studies in recent years, we propose potential solutions towards the existing problem in the methodology and applications of DSI technology as follows: (1) using compressed sensing to undersample data and to reconstruct the diffusion signal may be an efficient and promising method for reducing scanning time; (2) the probability density function includes more information than the orientation distribution function, and it should be extended in application studies; and (3) large-sample study is encouraged to confirm the reliability and reproducibility of findings in clinical diseases. These findings may help deepen the understanding of the DSI method and promote its development in clinical applications.

show abstract

Adult Attention-Deficit/Hyperactivity Disorder: a Narrative Review of Biological Mechanisms, Treatments, and Outcomes

Pagán,

Huizar,

Short

et al. 2023

Curr Neurol Neurosci Rep

View full text Add to dashboard Cite

Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study

Cited by 8 publications

References 34 publications

Adolescents with ADHD and co‐occurring motor difficulties show a distinct pattern of maturation within the corticospinal tract from those without: A longitudinal fixel‐based study

Adolescents with ADHD and co‐occurring motor difficulties show a distinct pattern of maturation within the corticospinal tract from those without: A longitudinal fixel‐based study

Research Progress in Diffusion Spectrum Imaging

Adult Attention-Deficit/Hyperactivity Disorder: a Narrative Review of Biological Mechanisms, Treatments, and Outcomes

Contact Info

Product

Resources

About