Atypical Cogan's syndrome: A case report and summary of current treatment options

Jančatová, Debora; Zeleník, Karol; Komínek, Pavel; Matoušek, Petr

doi:10.1016/j.ijporl.2014.12.028

Cited by 16 publications

(10 citation statements)

References 14 publications

(39 reference statements)

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“…Tedaviye olabildiğince erken başlanması ilerleyici işitme kaybının, vestibüler disfonksiyonun, irreversible görme bozukluklarının ve kardiyovasküler komplikasyonların önlenmesi açısından çok önemlidir (15) . İnterstisyel keratit tedavisinde topikal kortikosteroidler kullanılır ve genellikle bir hafta içerisinde göz bulguları düzelir.…”

Section: F Karaaslan Ve Ark Ender Görülen Inflamatuvar Bir Hastalıunclassified

“…Steroid tedavisine 1-2 hafta içinde yanıt alınamazsa tedaviye siklofosfamid (1-2 mg/kg/gün) veya metotrexat (7,5-10 mg/kg/gün) ya da siklosporin (1-2 mg/ kg/gün) gibi diğer immunsupressif ilaçlar eklenir. Hastalığa sistemik vaskülit eşlik ediyorsa yine prednizolon 1-2 mg/kg/gün dozda tek başına başlanır ve daha sonra yanıt durumuna göre yanına diğer immunsupresif ilaçlar eklenir (15) . Büyük damar tutulumunda siklosporin 3,5-5 mg/kg/gün, poliarteritte siklofosfamid 2 mg/kg/gün dozunda başlanır.…”

Section: F Karaaslan Ve Ark Ender Görülen Inflamatuvar Bir Hastalıunclassified

“…Cogan sendromunda son yıllarda yeni tedavi seçenekleri olarak plazmaferez, TNF-alfa inhibitörleri (infliximab), rituximab, tocilizumab ve mikofenolat mofetil kullanılmaktadır. Özellikle de infliximab ve rituximabın hastalığın erken döneminde çok etkili olduğu ve immünsüpresiflere olan gereksinimi azalttığı gösterilmiştir (15) .…”

Section: F Karaaslan Ve Ark Ender Görülen Inflamatuvar Bir Hastalıunclassified

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A Rare Inflammatory Disease: Cogan' s Syndrome

Karaaslan¹,

Gürakan²,

Kalçın³

et al. 2016

BUCH

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Cogan sendromu, ender görülen, nedeni bilinmeyen, özellikle görme ve işitmeyi etkileyen inflamatuvar bir hastalıktır. İnterstisyel keratit ve işitme kaybı bulguları ile karakterize olup, orta ve büyük damarları etkileyen vaskülitler tabloya eşlik edebilir. Bu olgu sunumunda, kliniğimize görme ve işitme yakınmaları ile başvurmuş ve Cogan sendromu tanısı almış 14 yaşında bir erkek hasta sunulmuştur.

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Section: F Karaaslan Ve Ark Ender Görülen Inflamatuvar Bir Hastalıunclassified

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A Rare Inflammatory Disease: Cogan' s Syndrome

Karaaslan¹,

Gürakan²,

Kalçın³

et al. 2016

BUCH

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“…При высокой активности СК и необходимости длительно-го назначения высоких доз ГК к терапии присоединяют цитостатики, в первую очередь МТ, который позволяет ре-дуцировать дозу ГК при отсутствии сообщений о неблаго-приятных реакциях [13,18,36,37]. Среди других цитоста-тиков, с переменным успехом используемых при СК, сле-дует отметить ЦФ, широко применяемый при воспали-тельной патологии глаз, азатиоприн, микофенолата мофе-тил, циклоспорин [10,13,15,[38][39][40].…”

Section: Cogan's Syndrome Is a New Nosological Entity In The Current unclassified

Cogan's syndrome is a new nosological entity in the current classification of systemic vasculitides: A clinical case and a review of literature

Бекетова¹

2016

rsp

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“…Cogan's syndrome (CS) is an inflammatory condition without a very clear origin. It was first described in 1945 by Dr. David Cogan, who identified concomitant ocular and audiovestibular symptoms in patients without evidence of syphilitic symptoms [ [1] , [2] , [3] ].…”

Section: Introductionmentioning

confidence: 99%

Sudden sensorineural hearing loss in atypical Cogan's syndrome: A case report

Gonzalez

Soto-Galindo

Sales

et al. 2018

Annals of Medicine and Surgery

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The Cogan's syndrome (CS) is a very uncommon inflammatory condition that appears in young adults without a gender predisposition. It can be presented as typical, with interstitial non-syphilitic keratitis and Ménière-like audiovestibular manifestations. An atypical form of CS involves uveitis, scleritis, episcleritis, and systemic vascuitis symptoms.This is a case of a 41-year old male who reported eye redness, photophobia, and gait instability. His condition progressed to a sudden sensorineural hearing loss, tinnitus, and constant vertigo accompanied by cephalea. He was evaluated by the Otolaryngology, Ophthalmology, and Neurology departments giving rise to CS, Ménière's syndrome, acoustic neuroma, glaucoma, multiple sclerosis, and meningioma as differential diagnoses. The patient was prescribed with oral and intravenous steroids, ophthalmic antibiotics and steroids, as well as oral omeprazole. The patient was discharged, without his eye manifestations, and for his clinical progress and underwent conventional and speech audiometry, otoacoustic emissions, nystagmography, tympanometry, and auditory steady-state response, that showed a vestibular disfunction and a severe sensorineural hearing loss. His follow-up, six months later resulted with a normal vestibular function and an improvement from severe to mild sensorineural hearing loss.The Cogan's syndrome is a rare condition which can leave the patient with permanent incapacitating secuelae including profound hearing loss. Effective treatment is necessary to avoid complications and improve the patient's condition and life quality.

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Atypical Cogan's syndrome: A case report and summary of current treatment options

Cited by 16 publications

References 14 publications

A Rare Inflammatory Disease: Cogan' s Syndrome

A Rare Inflammatory Disease: Cogan' s Syndrome

Cogan's syndrome is a new nosological entity in the current classification of systemic vasculitides: A clinical case and a review of literature

Sudden sensorineural hearing loss in atypical Cogan's syndrome: A case report

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