Atypical cerebral language dominance in a right-handed patient: An anatomoclinical study

Witte, Elke De; Hecke, Wim Van; Dua, G.; Surgeloose, Didier De; Moens, Maarten; Mariën, Peter

doi:10.1016/j.clineuro.2013.11.014

Cited by 15 publications

(9 citation statements)

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“…The effect was shifted to the right and confirmed by source localisation analyses, suggesting involvement of the right hemisphere at the group level. Evidence has accumulated for the right hemisphere's role in language functioning following damage to the language-dominant left hemisphere due to brain tumours (De Witte et al, 2014;Thiel et al, 2005; see also Traut et al, 2019, for right hemisphere shifts in the post-operative phase) similarly as found for stroke-induced lesions using MEG (e.g., Kielar, Deschamps, Jokel, & Meltzer, 2016;Piai et al, 2017). This phenomenon could explain the present findings.…”

Section: Discussionsupporting

confidence: 75%

Language neuroplasticity in brain tumour patients revealed by magnetoencephalography

Piai¹

2019

Preprint

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Language impairment in brain tumour patients may be missed since standardised tests fail to capture mild deficits. Neuroplasticity may also contribute to minimising language impairments. To address this possibility, we examined 14 patients with language dominant hemipsheric brain tumours prior to their first surgery using magnetoencephalography (MEG) imaging while they performed a demanding picture-word interference task. During pictureword interference, participants name pictures while ignoring distractor words. Brain tumour patients had the behavioural picture naming effects typically observed in healthy controls. By contrast, the MEG event-related effect had a right hemisphere source, in contrast to the classic left hemisphere source found in healthy individuals. This finding supports tumour induced neural reorganisation of language prior to surgery. We also identified one participant with a lesion affecting the left temporal lobe and underlying white-matter tracts who showed a deviant pattern in behaviour as well as in the MEG event-related responses. Our results provide support for neuroplasticity of language in brain tumours in the pre-surgical phase.

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Section: Discussionsupporting

confidence: 75%

Language neuroplasticity in brain tumour patients revealed by magnetoencephalography

Piai¹

2019

Preprint

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“…The involvement of the right hemisphere has been found postoperatively following resection of the left hemisphere, for example, using MEG (Traut et al, 2019). A number of studies has also identified right-hemisphere involvement in language function preoperatively (De Witte et al, 2014;Rösler et al, 2014;Krieg et al, 2013;Thiel et al, 2005), a pattern of reorganization likely induced by the tumor in the left hemisphere. The same explanation is likely for the present findings.…”

Section: Discussionmentioning

confidence: 99%

Language Neuroplasticity in Brain Tumor Patients Revealed by Magnetoencephalography

Piai

Witte

Sierpowska

et al. 2020

Journal of Cognitive Neuroscience

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Little is known about language impairment in brain tumor patients, especially in the presurgical phase. Impairment in this population may be missed because standardized tests fail to capture mild deficits. Additionally, neuroplasticity may also contribute to minimizing language impairments. We examined 14 presurgical patients with brain tumors in the language-dominant hemisphere using magnetoencephalography (MEG) while they performed a demanding picture–word interference task, that is, participants name pictures while ignoring distractor words. Brain tumor patients had behavioral picture-naming effects typically observed in healthy controls. The MEG responses also showed the expected pattern in its timing and amplitude modulation typical of controls, but with an altered spatial distribution of right hemisphere sources, in contrast to the classic left hemisphere source found in healthy individuals. This finding supports tumor-induced neural reorganization of language before surgery. Crucially, the use of electrophysiology allowed us to show the “same” neuronal response in terms of its timing and amplitude modulation in the right hemisphere, supporting the hypothesis that the processes performed by the right hemisphere following reorganization are similar in nature to those (previously) performed by the left hemisphere. We also identified one participant with a fast-growing tumor affecting large parts of critical language areas and underlying ventral and dorsal white matter tracts who showed a deviant pattern in behavior and in the MEG event-related responses. In conclusion, our results attest to the validity of using a demanding picture-naming task in presurgical patients and provide evidence for neuroplasticity, with the right hemisphere performing similar computations as the left hemisphere typically performs.

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“…Actualmente, hay un avance significativo respecto a la relación entre el hemisferio derecho y la pragmática, pero, aún existen discusiones al respecto, considerando variables socio demográficas, los instrumentos de evaluación empleadas y las funciones cognitivas involucradas en el procesamiento del lenguaje, además de la posibilidad de generalizar los hallazgos a otras poblaciones (50).…”

Section: Conclusiónunclassified

Hemisferios Cerebrales Y Habilidades Pragmáticas Del Lenguaje

Erazo¹

2014

Revisalud

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ResumenEl presente artículo es una revisión del estado del arte relacionado con las habilidades pragmáticas del lenguaje y su sustrato neuroanatómico. Se aborda el tema en cuestión mediante la revisión de publicaciones científicas pioneras y actuales que permiten concluir un avance significativo en la identificación de las estructuras cerebrales asociadas al procesamiento del lenguaje. Inicialmente existía la concepción del hemisferio izquierdo como dominante para el procesamiento del lenguaje, restándole importancia al hemisferio derecho.Las investigaciones a partir de la segunda mitad del siglo XX referente a las habilidades pragmáticas han demostrado que los trastornos del lenguaje en los pacientes con lesión cerebral derecha, son en general diferentes de aquellas observadas en pacientes con lesión izquierda, lo cual no indica que sean menos importantes desde la perspectiva clínica. Los estudios neuropsicológicos, el uso de técni-cas electrofisiológicas y de neuroimágen funcional han permitido analizar con mayor claridad la importancia de la integridad de ambos hemisferios cerebrales para una comunicación eficiente.En los diferentes estudios se han encontrado resultados ambiguos que en la actualidad son motivo de discusión considerando la complejidad de la pragmática del lenguaje y la demanda de recursos cognitivos necesarios para su procesamiento, además de variables como sitio y extensión de la lesión, plasticidad cerebral, variaciones estructurales del sistema nervioso, instrumentos de evaluación y variables socioculturales. En conclusión, no se podría atribuir el procesamiento de la pragmática del lenguaje a un hemisferio cerebral específico, dada la complejidad y los recursos cognitivos superiores que demanda esta modalidad de información.Palabras claves: Lenguaje, Lesión cerebral, semántica. AbstractThis article is a revision of the state of the art related with pragmatic language skills and their neuroanatomical substrate. The topic is approached through a revision of pioneer and current scientific publications that allow concluding a significant advance on identifying the cerebral structures associated to language processing. Initially, there was the concept of left hemisphere as dominant in language processing, reducing importance to right hemisphere.Research from the second half of the 20 th century on, about pragmatic skills have shown that learning disorders in patients with right brain injury, are generally different to those observed in patients with left brain injury, which does not imply these last ones to be less important from the clinical perspective.Neuropsychological studies, the use of electrophysiological techniques and functional neuroimaging have permitted analyzing more clearly the importance of both hemispheres integrity for an efficient communication.In the different studies, ambiguous results have been found and they are currently under discussion considering the complexity of language pragmatics and the demand of the necessary cognitive resources for its processing together with ...

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Atypical cerebral language dominance in a right-handed patient: An anatomoclinical study

Cited by 15 publications

References 40 publications

Language neuroplasticity in brain tumour patients revealed by magnetoencephalography

Language neuroplasticity in brain tumour patients revealed by magnetoencephalography

Language Neuroplasticity in Brain Tumor Patients Revealed by Magnetoencephalography

Hemisferios Cerebrales Y Habilidades Pragmáticas Del Lenguaje

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