Atypical/bizarre spindle-cell epithelial metaplasia in nodular goiter: a potential diagnostic pitfall

Magro, Gaetano; Torrisi, Antonietta

doi:10.1007/s00428-004-1128-8

Cited by 7 publications

(14 citation statements)

References 5 publications

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“…PSCNT occurs in patients who had previously undergone fine needle aspiration biopsy of thyroid nodule 2 . Margo et al 7 . reported nodular goiter associated with atypical/bizarre spindle‐cell metaplasia.…”

Section: Discussionmentioning

confidence: 99%

“…Such spindle cells have been rarely described in follicular adenoma and papillary carcinoma as spindle cell metaplasia 4–6 . Among nodular goiters, a case associated with atypical/bizarre spindle‐cell epithelial metaplasia has been reported 7 . A purpose of this paper is to describe pathological findings of our three cases and discuss the pathogenesis.…”

Section: Introductionmentioning

confidence: 86%

“…[4][5][6] Among nodular goiters, a case associated with atypical/bizarre spindle-cell epithelial metaplasia has been reported. 7 A purpose of this paper is to describe pathological findings of our three cases and discuss the pathogenesis.…”

Section: Introductionmentioning

confidence: 97%

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Benign nodular goiter with spindle cell component

Hirokawa¹,

Haba²,

Kushida

et al. 2010

Pathology International

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We report three benign nodular goiters associated with spindle cell component. The spindle cells were bland, and showed short fascicular pattern or formed small nests. The cytoplasm was pale or clear. A transition between follicular cells and the spindle cells was observed. Immunohistochemically, they were positive for thyroglobulin and thyroid transcription factor-1. They did not react against CD34. Ki-67 (MIB-1) labeling indexes were less than 1%. We thought that the spindle cells are derived from follicular cell and non-neoplastic, and it is important to recognize this lesion to distinguish from aggressive and lethal components seen in papillary carcinoma or anaplastic carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

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Benign nodular goiter with spindle cell component

Hirokawa¹,

Haba²,

Kushida

et al. 2010

Pathology International

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“…reported in Virchows Archiv [4] the possibility that nodular goiter may contain follicularderived atypical/bizarre spindle cells that may represent a potential diagnostic pitfall. In this regard, we have encountered a unique spindle cell thyroid tumor bearing a striking morphological resemblance to a meningioma.…”

mentioning

confidence: 94%

“…The meningioma-like features should be interpreted as a variant on the theme of the follicular-derived spindle cell metaplasia, a phenomenon which is known to occur occasionally in both benign and malignant thyroid lesions [3][4][5]7]. The importance of recognizing this variant for pathologist is to avoid confusion with other benign and malignant spindle cell lesions.…”

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confidence: 99%

Meningioma-like tumor of the thyroid. A previously undescribed variant of follicular adenoma

2005

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Spindle cell variant of follicular thyroid carcinoma: An extremely unusual case and review of the literature

Pusztaszeri

Florianova

Payne

et al. 2022

Diagnostic Cytopathology

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Spindle cell proliferations originating in follicular derived thyroid neoplasms are rare and known to cause diagnostic conundrums. We describe a unique case of a spindle cell variant of follicular thyroid carcinoma (FTC) in a 48‐year‐old female without relevant past medical history, who was being followed for a 1.4 cm left thyroid nodule for the past 15 months. A fine needle aspiration (FNA) of the nodule was interpreted as benign (Bethesda II). On follow‐up ultrasound the nodule demonstrated a slight increase in size (to 1.5 cm) and the appearance of coarse calcifications A repeat FNA was performed 12 months later and interpreted as malignant neoplasm (Bethesda VI), containing a population of spindle and epithelioid cells that could not be further classified. A left subtotal thyroidectomy showed an encapsulated tumor mainly composed of fibroblast‐like spindle cells, extensive foci of calcifications and focal ossification, with minimal tumor capsule invasion without vascular invasion. Tumor cells expressed vimentin, ERG and SMA (focal), while being negative for pancytokeratin, thyroglobulin, TTF‐1, Pax‐8, calcitonin, CEA and other lineage‐specific mesenchymal, neuroendocrine and melanocytic markers. Importantly, a few residual thyroid follicles were identified within the nodule, and a diagnosis of minimally invasive FTC with extensive spindle cell changes, calcification and osseous metaplasia was rendered. This is only the second cytologic report of a pure spindle cell FTC. The rarity of this neoplasm and its potential broad differential diagnosis create diagnostic difficulties both on cytology and histology.

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Atypical/bizarre spindle-cell epithelial metaplasia in nodular goiter: a potential diagnostic pitfall

Cited by 7 publications

References 5 publications

Benign nodular goiter with spindle cell component

Benign nodular goiter with spindle cell component

Meningioma-like tumor of the thyroid. A previously undescribed variant of follicular adenoma

Spindle cell variant of follicular thyroid carcinoma: An extremely unusual case and review of the literature

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