Atypical apocrine proliferation involving anogenital mammary‐like glands of the perianal region

Charfi, Slim; Sevestre, Henri; Dumont, Frédéric; Régimbeau, Jean-Marc; Chatelain, Denis

doi:10.1111/j.1600-0560.2008.01215.x

Cited by 12 publications

(6 citation statements)

References 10 publications

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“…This lesion was excised and had no recurrence, but it illustrates the complexity of MLG neoplasms. 48 The reported case, similar to ours, presented with mixed histology of SCAP and MLGs. 5 There are also reported cases of pseudoangiomatous stromal hyperplasia in lesions of anogenital MLGs, all with complex histology.…”

Section: Discussionsupporting

confidence: 69%

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

Parks

Branch²,

Metcalf³

et al. 2012

The American Journal of Dermatopathology

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Hidradenoma papilliferum of the anogenital region was previously believed to originate from apocrine glands but has recently been accepted as originating from anogenital mammary-like glands. We describe a case of hidradenoma papilliferum with mixed features of syringocystadenoma papilliferum and mammary-like glands from the left labia majora of a 25-year-old woman. Histopathologically, the lesion showed an epithelial lining with apocrine secretion, and like syringocystadenoma papilliferum, the lesion extended from the epithelium as invaginations into the dermis. Adjacent to this lesion were ductal and glandular structures resembling normal mammary tissue. This review of the literature highlights the heterogeneity and complexity of lesions arising from anogenital mammary-like glands, and this case serves as further documentation of the association between anogenital mammary-like glands and hidradenoma papilliferum.

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Section: Discussionsupporting

confidence: 69%

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

Parks

Branch²,

Metcalf³

et al. 2012

The American Journal of Dermatopathology

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“…While the abnormalities did not conform to any one specific breast entity, such features can be seen in fibrocystic change, fibroepithelial lesions (fibroadenoma, phyllodes tumor), papillomas and sclerosing lesions of the breast. Similar histopathologic findings in mammary‐like glands were reported by Charfi et al who describe a 10 cm perianal complex lesion in an 85‐year‐old woman with features of fibroadenoma, adenosis, epithelial hyperplasia and apocrine and cystic change . To our knowledge, this is the first case of a proliferative lesion arising in a mammary‐like gland in the setting of Cowden syndrome.…”

Section: Discussionsupporting

confidence: 87%

Proliferative lesion of anogenital mammary‐like glands in the setting of Cowden syndrome: case report and review of the literature

et al. 2016

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Mammary-like glands are normal appendages of anogenital skin and can give rise to epithelial and stromal tumors that closely resemble breast tumors. Cowden syndrome is an autosomal-dominant cancer-predisposition syndrome that is associated with increased risk of various benign and malignant tumors including breast cancers. Here, we report the first case of a proliferative lesion of mammary-like glands in the setting of Cowden syndrome. A 27-year-old female with Cowden syndrome (R130Q-PTEN mutation) presented with a 1-cm tender, polypoid perianal lesion. An excisional biopsy revealed a circumscribed, lobulated lesion with fibromyxoid stroma and epithelial hyperplasia with apocrine and columnar cell changes that was arranged in papillary, micropapillary and focal cribriform architecture. The features strikingly resembled proliferative changes commonly seen in the breast. Interestingly, the patient subsequently developed an atypical complex sclerosing lesion of the breast. Given the increased risk of breast neoplasia in Cowden syndrome, and the morphologic relationship between breast glands and mammary-like glands, this case raises the possibility of an increased risk of neoplasia arising in mammary-like glands in the setting of Cowden syndrome.

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“…13,14 Hidradenoma papilliferum occasionally exhibits atypical features, such as increased mitotic activity, necrosis, nuclear atypia, or a cribriform growth pattern. [15][16][17] These atypical features raise concern for malignant potential; however clinical follow-up data on such cases has not been reported. Rarely, hidradenocarcinoma papilliferum has been reported showing in situ [18][19][20] and invasive components.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma of anogenital mammary gland type arising from encapsulated papillary carcinoma: A rare vulvar tumor mimicking breast carcinoma

Tang,

Laskin,

Luan

et al. 2024

J Cutan Pathol

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Anogenital mammary‐like glands are normal structures of the anogenital region. Tumors originating from these glands often exhibit a striking resemblance to their mammary gland counterparts. Herein, we present a rare case of adenocarcinoma of mammary gland type in the vulva of a 69‐year‐old female. Histopathologic examination revealed a complex lesion, which included a large encapsulated papillary carcinoma (EPC) with associated invasive carcinoma of mammary gland type and ductal carcinoma in situ (DCIS). The invasive component consisted mostly of invasive ductal carcinoma of no special type, with a notable focus of invasive mucinous carcinoma. p40 immunostain demonstrated a lack of myoepithelial cells in both the EPC and invasive carcinoma, but such cells expressed p40 around the ducts involved by DCIS. The main component of this lesion, EPC, was characterized by a papillary proliferation within a cystic space surrounded by a fibrous capsule without a myoepithelial layer. The histopathologic features of anogenital EPC closely resemble cutaneous hidradenoma papilliferum. Indeed, there have been a few reports in the literature describing cases where in situ and invasive carcinoma arose from a preexisting hidradenoma papilliferum. As tumors of anogenital mammary‐like glands bear a closer resemblance to breast lesions than to skin tumors, we recommend that they be aligned with the classification of well‐established breast lesions rather than cutaneous adnexal tumors.

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Atypical apocrine proliferation involving anogenital mammary‐like glands of the perianal region

Cited by 12 publications

References 10 publications

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

Proliferative lesion of anogenital mammary‐like glands in the setting of Cowden syndrome: case report and review of the literature

Adenocarcinoma of anogenital mammary gland type arising from encapsulated papillary carcinoma: A rare vulvar tumor mimicking breast carcinoma

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