Abstract:The rare neuroleptic malignant syndrome (NMS) is associated with early mortality of >30%. Better supportive care has reduced mortality to <10%. Atypical antipsychotics such as clozapine and risperidone are associated with an atypical but potentially lethal, NMS. A 22-year-old male developed NMS after being treated with clozapine and risperidone for aggression associated with mental retardation for about 8 years. For the past 1 year, the dose of clozapine was 200 mg/day and the dose of risperidone was 8 m… Show more
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