Atypical and Malignant Variants of Ossifying Fibromyxoid Tumor

Kilpatrick, Scott E.; Ward, William G.; Mozes, M; Miettinen, Markku; Fukunaga, Masao; Fletcher, Christopher D.�M.

doi:10.1097/00000478-199509000-00007

Cited by 105 publications

(94 citation statements)

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“…Este caso clínico muestra varias cosas, en primer lugar que en la literatura se han reportado aproximadamente 220 casos de TFO, principalmente a través de la comunicación de casos clínicos y algunas series de distintos tamaños [1][2][3][4][5][6][7][8][9] , destacando el estudio de Miettinen et al sados, tomando como base la muestra analizada por Enzinger y ampliando el período de análisis a 37 años. El TFO es un tumor de muy baja frecuencia, por lo que es fácil que sea confundido, como en este caso, en que fue interpretado como un cáncer anaplásico de tiroides, lo que previamente ya había sido reportado en la tiroides, pero con una neoplasia folicular 10 .…”

Section: Discussionunclassified

“…A pesar de esto, mantiene una característica que le otorga un mayor grado de agresividad que un TFO típico, que es la infiltración de estructuras vecinas, lo que no se explica por la radioterapia, además clínicamente la paciente evolucionó con disfagia progresiva, lo que habla de un tumor localmente agresivo. Se han descrito una serie de variantes atípicas de TFO que poseen un mayor grado de atipia celular y que clínicamente se manifiestan con mayor tendencia a recurrir localmente e incluso dar metástasis [3][4][5][6][7] , como en la serie de Folpe en que 8 pacientes, de un total de 70, tuvieron metástasis a distancia (principalmente pulmón). Así, la recurrencia variaría entre un 18% y un 22% según las distintas series, en plazos que van desde los 6 años hasta los 10 años, lo que concuerda con este caso.…”

Section: Discussionunclassified

“…El tratamiento es la resección local con márge-nes libres. Se ha descrito recurrencia local hasta en un tercio de los casos 1,2 y una muy baja posibilidad de metástasis, sin embargo, han surgido reportes de casos más agresivos, con características histológicas especiales, que presentan mayor recurrencia local y posibilidad de metástasis [3][4][5] . Aún quedan muchas dudas sobre este tumor, principalmente sobre su histogénesis, alteraciones genéticas asociadas 6 y la real clasificación de las variantes malignas dado su difícil diagnóstico diferencial histológico con otros tumores de partes blandas.…”

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Tumor fibromixoide osificante simulando un cáncer anaplásico de tiroides: Reporte de un caso

Amat

et al. 2009

Rev Chil Cir

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Ossifying fibromyxoid tumor of the neck. Case reportOssifying fibromyxoid tumor of soft parts in an uncommon tumor with a benign behavior but with a tendency to relapse. We report a 76 years old female presenting with a growing mass located in the anterior portion of the neck that was excised. The pathological study disclosed an anaplastic thyroid cancer. The patient received chemotherapy and was lost from follow up. Nine years later, she presented with progressive dysphagia. A neck CT scan showed a mass in the left thyroid base that completely included the cervical esophagus. The patient was operated and the mass was excised. The pathological diagnosis disclosed an ossifying fibromyxoid tumor.Key words: Ossifying fibromyxoid tumor, Anaplastic thyroid cancer. ResumenEl tumor fibromixoide osificante corresponde a una neoplasia infrecuente, de comportamiento benigno pero que presenta recurrencia en un tercio de los casos, comportándose como un sarcoma de bajo grado. Se reporta el caso de una paciente operada de tiroides en dos oportunidades en 9 años, cuyo diagnóstico final fue tumor fibromixoide osificante.Palabras clave: Tumor fibromixoide osificante, cáncer anaplásico de tiroides.

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Section: Discussionunclassified

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Tumor fibromixoide osificante simulando un cáncer anaplásico de tiroides: Reporte de un caso

Amat

et al. 2009

Rev Chil Cir

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“…An aggressive variety of OFMTs, such as the "malignant" or "atypical" type, is characterized by the presence of hypercellularity, a centrally placed osteoid, a high nuclear grade, and an increase in mitotic activity. Kilpatrick et al 9 suggested that malignant tumors were those with evidence of metastasis, and atypical tumors were aggressive masses without any evidence of …”

Section: Discussionmentioning

confidence: 99%

Sonographic Features of an Ossifying Fibromyxoid Tumor of the Buttock

Choi

Park

Jin

et al. 2008

Journal of Ultrasound in Medicine

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n ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm that presents as a solitary painless well-circumscribed mass usually located in the subcutaneous layer of the trunk or extremities. 1,2 The lesion mainly affects adults and is slightly predominant in men. 2 Almost all of the cases reported in the past were based on the clinical and histologic findings of OFMTs, with only a few reports about radiologic findings. To our knowledge, there have been no previous reports that described the sonographic features of this uncommon tumor. Here we describe the clinical, sonographic, and histologic findings in a case of an OFMT of the buttock. Case ReportA 24-year-old man came to our clinic with a nontender mass on his right buttock, which had been growing slowly for the past 6 months. On physical examination, there was a hard movable well-circumscribed mass that measured about 5.0 × 3.0 × 3.0 cm. Sonography of the central portion of the right buttock was done with an iU22 scanner and a 17-5 linear array transducer (Philips Medical Systems, Eindhoven, the Netherlands). It revealed a well-demarcated oval hypoechoic mass located just below the skin. There were marginal calcifications with posterior shadowing at both lateral aspects ( Figure 1A), and on color Doppler imaging, the inner portion showed an avascular lesion with posterior enhancement ( Figure 1B). The size of the mass was 4.3 × 2.9 × 1.9 cm. Muscle involvement and surrounding soft tissue infiltration were not seen. A presumptive diagnosis of an epidermoid cyst was made, and wide local excision of the mass was performed under spinal anesthesia with the patient in the prone position.

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“…Subsequently to the original description of this entity by Enzinger et al, 5 Folpe and Weiss 6 proposed the classification of OFMTs into typical, atypical, and malignant variants based on nuclear grade, cellularity, and mitotic rate. Atypical and malignant variants, as characterized by Kilpatrick et al, 7 exhibit increased cellularity, increased mitotic activity, and centrally placed osteoid. Histologically benign tumors may recur (17%) or rarely metastasize (5%).…”

Section: Commentmentioning

confidence: 99%

Ossifying Fibromyxoid Tumor of the Breast Mimicking Fibroadenoma: A Case Report and Differential Diagnoses

Asirvatham

Shah

Carreon

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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An 80-year-old woman presented with a palpable mass in the right breast. Mammographic findings were consistent with calcified fibroadenoma. An ultrasound was performed that showed a solid nodule with peripheral calcification. A core biopsy was obtained that revealed a spindle cell proliferation with a shell of mature bone. The histologic features, in combination with immunohistochemical studies, were those of an ossifying fibromyxoid tumor. Complete excision of the specimen further confirmed the diagnosis. To the best of our knowledge, this is the first reported case of ossifying fibromyxoid tumor occurring in the breast. We review the current literature on ossifying fibromyxoid tumor and discuss the differential diagnoses when confronted with bland spindle cells on a core biopsy of the breast.

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Atypical and Malignant Variants of Ossifying Fibromyxoid Tumor

Cited by 105 publications

References 0 publications

Tumor fibromixoide osificante simulando un cáncer anaplásico de tiroides: Reporte de un caso

Tumor fibromixoide osificante simulando un cáncer anaplásico de tiroides: Reporte de un caso

Sonographic Features of an Ossifying Fibromyxoid Tumor of the Buttock

Ossifying Fibromyxoid Tumor of the Breast Mimicking Fibroadenoma: A Case Report and Differential Diagnoses

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