Atypical and malignant granular cell tumors in Japan: a Japanese Musculoskeletal Oncology Group (JMOG) study

Abstract

MGCTs have high rates of recurrence and metastasis including lymph node metastasis. As histologically atypical cases also have metastatic potential, close attention should be paid to AGCTs. The combination of histological evaluation and tumor size may lead to more accurate diagnosis of this rare neoplasm.

Malignant granular cell tumor: Clinical features and long‐term survival

“…This study confirmed characteristics of GCT as well as its management previously described in published reports such as a predilection to affect females more often than males, occurrence in a wide variety of locations, and excision alone as the primary treatment . Benign GCT appears to occur most often in the head neck region, while, as found in this study, malignant GCT occurs most frequently in the soft tissues and skin …”

“…As mentioned above, the primary treatment of GCT has traditionally been surgical excision, without regional lymphadenectomy . Although seldom reported in the literature, lymph node dissection does occur.…”

“…Radiotherapy and chemotherapy were used in 12.4% (14 of 113) and 8.9% (10 of 113) of patients in the current study, and use was associated with significantly poorer survival. The use of nonsurgical therapy has rarely been described in the literature . One report described the case of a 54‐year old male treated with Pazopanib after undergoing palliative resection of recurrent malignant GCT of the right upper back that metastasized to the right axillary lymph nodes, right thigh and lung .…”

“…One report described the case of a 54‐year old male treated with Pazopanib after undergoing palliative resection of recurrent malignant GCT of the right upper back that metastasized to the right axillary lymph nodes, right thigh and lung . Chemotherapy has largely been used for locally recurrent disease or metastasis . The use of radiotherapy has also been described as both adjuvant and palliative therapies …”

“…Chemotherapy has largely been used for locally recurrent disease or metastasis . The use of radiotherapy has also been described as both adjuvant and palliative therapies …”