Atypical adult non-calcified pilomatricoma

Masih, Sulabha; Sorenson, Steven; Gentili, Amilcare; Seeger, Leanne L.

doi:10.1007/s002560050010

Cited by 18 publications

(12 citation statements)

References 8 publications

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“…PMX may be diagnosed from sebaceous cysts by noninvasive physical imaging examinations such as general radiography, ultrasound sonography, magnetic resonance imaging and computed tomography (CT) scan (Fujioka et al, 2003;Imperiale et al, 2001;Masih et al, 2000;Som et al, 1998). The majority of these techniques are capable of providing morphological or structural information, but none of them are able to provide information about the chemical composition of PMX.…”

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confidence: 99%

Micro‐Raman spectroscopy used to identify and grade human skin pilomatrixoma

Cheng¹,

Liu²,

Liu³

et al. 2005

Microscopy Res & Technique

294

181

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Raman microspectroscopy was applied to analyze the changes in structural conformation and chemical composition of the mass of human skin pilomatrixoma (PMX). The normal skin dermis, collagen type I, and hydroxyapatite (HA) were used as control. The excised specimens from two patients diagnosed as a typical PMX were detected, in which one specimen was a soft mass, but the other was a hard mass with somewhat calcified deposits via histopathological examination. The Raman spectrum of normal skin dermis was found to be similar to the Raman spectrum of collagen type I, confirming that the collagen type I was a predominant component in normal skin dermis. The differences of Raman peak intensity between normal skin dermis and soft or hard PMX mass were obvious at 1,622-1,558, 1,400-1,230, 1,128, 1,000-850, 749, and 509 cm(-1). In particular, the peak at 1,665 cm(-1) assigned to amide I band shifted to 1,655 cm(-1) and the peak at 1,246 cm(-1) corresponding to amide III band was reduced in its intensity in hard PMX mass. The significant changes in collagen content and its structural conformation, the higher content of tryptophan, and disulfide formation in PMX masses were markedly evidenced. In addition, the shoulder and weak peak at 960 cm(-1) assigned to the stretching vibration of PO(4) (3-) of HA also appeared respectively in the Raman spectra of soft and hard PMX masses, suggesting the occurrence of calcification of HA in the PMX tissue, particularly in the hard PMX mass. The result indicates that the micro-Raman spectroscopy may provide a highly sensitive and specific method for identifying normal skin dermis and how it differs in chemical composition from different PMX tissues.

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confidence: 99%

Micro‐Raman spectroscopy used to identify and grade human skin pilomatrixoma

Cheng¹,

Liu²,

Liu³

et al. 2005

Microscopy Res & Technique

294

181

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“…The authors suggested that the hyperintense bands noted on the T2-weighted images might correspond to the basaloid bands present on the histologic specimens. On the other hand, Masih et al (8) put forward another possible explanation for this observation, suggesting that the high signal intensity reticulations might represent edematous stroma surrounding basaloid cells.…”

Section: Discussionmentioning

confidence: 99%

A Case of Pilomatricoma in the Upper Arm: Sonographic and MR Imaging Findings

Lee

Suh

2005

J Korean Radiol Soc

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“…Peripheral enhancement of connective tissue and/or patchy or reticular central enhancement of intercellular stroma on contrast-enhanced T1W images are characteristic. 33 …”

Section: Pilomatricomamentioning

confidence: 99%