Atypical acute retinal necrosis (ARN) responding to late treatment

Tsinopoulos, Ioannis; Tranos, Paris; Topouzis, Fotis; Hundal, K S; Brazitikos, Periklis

doi:10.1038/sj.eye.6700579

Cited by 3 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They suggested that IVTA may cause the risk of long-lasting local immunosuppression and vulnerability to primary infection or reactivation of endogenous latent viral retinitis. In our case TA dose was only 4 mg and we found that lower dose can also cause immunosupression and induce viral retinitis [14,15].…”

Section: Discussionmentioning

confidence: 76%

“…This delay may lead to complications resulting in blindness. Poor vision usually is due to rhegmatogenous retinal detachment or optic neuritis [11][12][13].Risk factors for ARN include young age, history of neurosurgery, periocular trauma, compromised immune status, Adminstration of local immunosuppressives in the vitreous, and a history of viral retinitiA [12][13][14]. In our case patient was administered IVTA.…”

Section: Discussionmentioning

confidence: 81%

“…In our case typical exudates in vitreous as well as in anterior chamber and RCS thickening were not noted. CMV retinitis also excluded by aqueous chamber PCR sample, in CMV retinitis lesions were located along the retinal blood vessels and sometimes on fovea and disc [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Acute Retinal Necrosis After Intravitreal Triamcinolone Acetonide For Aphakic Macular Edema- A Case Report

Sulatana¹

2017

APJHS

View full text Add to dashboard Cite

Triamcinolone acetonide is used in the form of intravitreal injection to treat ocular diseases like uveitis, vasculitis, proliferative vitreoretinopathy, macular degeneration etc. But complications have been reported after injection like elevated intraocular pressure and cataract. Even though rare, acute retinal necrosis is a risky complication after intraocular Triamcinolone acetonide injection, which may cause potential blindness. Here we report a case of acute retinal necrosis following intravitreal injection of Triamcinolone acetonide and review the relevant literature.

show abstract

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 81%

See 1 more Smart Citation

Acute Retinal Necrosis After Intravitreal Triamcinolone Acetonide For Aphakic Macular Edema- A Case Report

Sulatana¹

2017

APJHS

View full text Add to dashboard Cite

show abstract

“…Posterior pole involvement is very rare and typically occurs at late or advanced stages in the disease course. 19 , 20 , 21 An advanced stage of the disease at the time of initiation of antiviral therapy has been associated with a poor outcome. 22 The mean interval between symptom onset and the seeking of medical attention in the present study was twice as long for the elderly patients as for the middle-aged subjects.…”

Section: Discussionmentioning

confidence: 99%

Poor prognosis of elderly individuals >80 years of age with acute retinal necrosis

Yanai

Harada

Uchi

et al. 2017

American Journal of Ophthalmology Case Reports

View full text Add to dashboard Cite

PurposeTo report the clinical features and prognosis of acute retinal necrosis (ARN) in elderly (>80 years of age) individuals.MethodsSix consecutive patients with unilateral ARN who attended the Department of Ophthalmology at Yamaguchi University Hospital between 2014 and 2015 were retrospectively reviewed. Clinical characteristics, causative virus, time from symptom onset to physician visit, visual acuity at presentation and final visit, and treatment were evaluated and compared between the three elderly and three middle-aged (<80 years) patients.ResultsVaricella zoster virus (VZV) DNA was detected in aqueous humor by the polymerase chain reaction in all six cases. The mean ± SD time between symptom onset and medical attention was 18.0 ± 8.7 and 8.3 ± 1.5 days in the elderly and middle-aged groups, respectively. All patients were treated with intravenous aciclovir, oral prednisolone, and a nonsteroidal anti-inflammatory drug, and five of the six patients also received oral valaciclovir and underwent vitrectomy. The final best corrected visual acuity of the affected eye was worse for the elderly patients (20/400, hand motion, and light perception negative) than for the middle-aged patients (20/15, 20/50, and 20/25).Conclusions and importanceARN in the elderly individuals of the present study was caused by VZV infection and associated with a poorer visual prognosis compared with that of middle-aged patients. A delay in the onset of antiviral treatment might contribute to the poor prognosis of elderly patients with ARN.

show abstract

“…Posterior pole involvement is very rare in its early stage 1,2 and may occur late in the disease course. 1, 3 We describe a case where macular exudation was the presenting feature of ARN.…”

mentioning

confidence: 99%