Atypia of Undetermined Significance on Thyroid Fine Needle Aspiration Cytology: Pathological Evaluation and Risk Factors for Malignancy

Abstract

Objective:This study was performed to analyze the surgical pathology results of thyroid fine-needle aspiration (FNA) cytology categorized as atypia of undetermined significance (AUS). Results: A total of 44 female patients and 11 male patients were included in this study. Among the 55 cases, 27 (49.1%) had final diagnosis of malignancy and 28 (50.9%) had benign lesions according to pathological evaluation. Both univariate and multivariate analysis revealed that only ultrasonographic finding of suspected malignancy was associated with malignant pathology. Conclusion:The risk for malignancy should be determined in the initial stage and high-risk patients with cytology classified as AUS should be recommended for surgery. In this study, the patients had a high preoperative risk of malignancy; thus, our pathological results had a high rate of malignancy.

Önemi̇ Beli̇rsi̇z Ati̇pi̇li̇ Hastalardaki̇ Postoperati̇f Hi̇stopatoloji̇k Mali̇gni̇te Varliği

“…This condition demonstrates that Bethesda Classification's category rates may vary in different countries. In a similar study conducted in our country, the malignancy rate was 49.1% (6). In the present study, thyroid malignancy rates were similarly high.…”

The Comparatıve Evaluatıon of Fine Needle Aspiration Biopsy Results of the Cases Which Are Atypia of Undetermined Significance and the Surgical Material Results

“…Çalışmanın amacı İİAB sonucu önemi belirsiz atipi (Bethesda kategori 3) olarak raporlanan hastaların ameliyat materyallerindeki patoloji sonuçlarının İİAB sonuçları ile karşılaştırmalı olarak değerlendirilmesi, sonuçları literatürle paylaşarak hastaların tedavi ve takibine katkı sağlamaktır. Ultrasonografi sonuçlarında nodüldeki düzensiz sınırlar, mikrokalsifikasyon varlığı, hipoekojenite, internal kanlanma ve hızlı büyüme malign şüpheli radyolojik görünümler olarak kabul edilmektedir (8,9). Malignite işareti olabilecek ultrasonografik özellikler temel alınarak geliştirilen TI-RADS ( Tiroid Görüntüleme Raporlama Veri Sistemi) sınıflamasında nodüller altı kategoriye ayrılmıştır.…”