Attributable mortality of central line associated bloodstream infection: systematic review and meta-analysis

Ziegler, Matthew J.; Pellegrini, Daniela; Safdar, Nasia

doi:10.1007/s15010-014-0689-y

Cited by 194 publications

(150 citation statements)

References 28 publications

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“…After implementation of the interventions, the CLABSI rate decreased nearly 70% from 2.03 CLABSI/1000 line days (June 2013–May 2014) to 0.39 CLABSIs/1000 line days (June 2014–May 2015) despite several continued stressors to our healthcare delivery system. Potentially, these interventions prevented 32 additional CLABSIs; healthcare costs of US$2 000 000; 640 additional hospital days; and 2–4 deaths 4 29…”

Section: Discussionmentioning

confidence: 99%

Rapid cycle development of a multifactorial intervention achieved sustained reductions in central line-associated bloodstream infections in haematology oncology units at a children’s hospital: a time series analysis

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Rapid cycle development of a multifactorial intervention achieved sustained reductions in central line-associated bloodstream infections in haematology oncology units at a children’s hospital: a time series analysis

et al. 2015

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“…According to a recent systematic review and meta-analysis, the odds ratio for in-hospital death due to CLABSI was 2.75 [CI 1.86-4.07], decreasing to 1.51 [CI 1.02-2.65] when patients were matched using an illness severity index [1].…”

Section: Incidence Of Clabsi and Clinical Outcomementioning

confidence: 99%

Antimicrobial lock therapy in central-line associated bloodstream infections: a systematic review

Vassallo

Dunais

Roger³

2015

Infection

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“…In these patients, CVCrelated bloodstream infections (CRBSIs) are important and common complications, especially during neutropenia. CRBSIs are associated with high morbidity and mortality [1][2][3][4]. Unfortunately, diagnosis of CRBSI is difficult and frequently based on clinical signs before removal of CVC [5,6].…”

Section: Introductionmentioning

confidence: 99%

Prediction of central venous catheter–related bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS)

et al. 2015

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The aim of this study was to predict the probability of central venous catheter-related bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified version of the Infection Probability Score (mIPS). In order to perform a prospective, mono-centric surveillance of complications in clinical routine due to short-term central venous catheters (CVCs) in consecutive patients receiving chemotherapy from March 2013 to September 2014, IPS was calculated at CVC insertion and removal (mIPSin and mIPSex, respectively). We used the 2012 Infectious Diseases Working Party of the German Society of Haematology and Medical Oncology (AGIHO/DGHO) criteria to define CRBSI. In total, 143 patients (mean 59.5 years, 61.4 % male) with 267 triple-lumen CVCs (4044 CVC days; mean 15.1 days, range 1-60 days) were analysed. CVCs were inserted for therapy of acute leukaemia (53.2 %), multiple myeloma (24.3 %) or lymphoma (11.2 %), and 93.6 % were inserted in the jugular vein. A total of 66 CRBSI cases (24.7 %) were documented (12 definite/13 probable/41 possible). The incidence was 16.3/1000 CVC days (2.9/3.1/10.1 per 1000 CVC days for definite/probable/possible CRBSI, respectively). In CRBSI cases, the mIPSex was higher as compared to cases without CRBSI (13.1 vs. 7.1; p < 0.001). The best mIPSex cutoff for CRBSI prediction was 8 points (area under the curve (AUC) = 0.77; sensitivity = 84.9 %, specificity = 60.7 %, negative predictive value = 92.4 %). For patients with an mIPSex ≥8, the risk for a CRBSI was high (odds ratio [OR] = 5.9; p < 0.001) and even increased if, additionally, CVC had been in use for about 10 days (OR = 9.8; p < 0.001). In case other causes of infection are excluded, a mIPSex ≥8 and duration of CVC use of about 10 days predict a very high risk of CRBSI. Patients with a mIPSex <8 have a low risk of CRBSI of 8 %.

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Attributable mortality of central line associated bloodstream infection: systematic review and meta-analysis

Abstract: CLABSI is associated with a significantly increased risk of death supporting the use of extensive efforts to reduce these infections.

Cited by 194 publications

References 28 publications

Rapid cycle development of a multifactorial intervention achieved sustained reductions in central line-associated bloodstream infections in haematology oncology units at a children’s hospital: a time series analysis

Rapid cycle development of a multifactorial intervention achieved sustained reductions in central line-associated bloodstream infections in haematology oncology units at a children’s hospital: a time series analysis

Antimicrobial lock therapy in central-line associated bloodstream infections: a systematic review

Prediction of central venous catheter–related bloodstream infections (CRBSIs) in patients with haematologic malignancies using a modified Infection Probability Score (mIPS)

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