Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study

Salmanton-García, Jon; Cornely, Oliver A.; Stemler, Jannik; Barać, Aleksandra; Steinmann, Jörg; Siváková, Alena; Akalin, Emin Halis; Arikan-Akdagli, Sevtap; Loughlin, Laura; Toscano, Cristina; Narayanan, Manjusha; Rogers, Benedict; Willinger, Birgit; Akyol, Deniz; Roilides, Emmanuel; Lagrou, Katrien; Mikulska, Malgorzata; Denis, Blandine; Ponscarme, Diane; Scharmann, Urlike; Azap, Alpay; Lockhart, Deborah; Bicanic, Tihana; Kron, Florian; Erben, Nurettin; Rautemaa-Richardson, Riina; Goodman, Anna L.; Garcia-Vidal, Carolina; Lass-Flörl, Cornelia; Gangneux, Jean-Pierre; Taramasso, Lucia; Ruiz, Maite; Schick, Yael; Van Wijngaerden, Eric; Milacek, Christopher; Giacobbe, Daniele Roberto; Logan, Clare; Rooney, Emily; Gori, Andrea; Akova, Murat; Bassetti, Matteo; Hoenigl, Martin; Koehler, Philipp

doi:10.1016/j.jinf.2024.106229

Journal of Infection

2024

DOI: 10.1016/j.jinf.2024.106229

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Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study

Jon Salmanton-García,

Oliver A. Cornely,

Jannik Stemler

et al.

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Insights from Three Pan-European Multicentre Studies on Invasive Candida Infections and Outlook to ECMM Candida IV

Wolfgruber,

Sedik,

Klingspor

et al. 2024

Mycopathologia

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Invasive candidiasis and candidemia remain a significant public health concern. The European Confederation of Medical Mycology (ECMM) conducted three pan-European multicentre studies from 1997 to 2022 to investigate various aspects of invasive Candida infections. These studies revealed shifting trends in Candida species distribution, with an increase of non-albicans Candida species as causative pathogens, increasing rates of antifungal resistance, and persistently high mortality rates. Despite advancements in antifungal treatment, the persistently high mortality rate and increasing drug resistance, as well as limited drug access in low-income countries, underscore the need for continued research and development in the treatment of Candida infections. This review aims to summarize the findings of the three completed ECMM Candida studies and emphasize the importance of continued research efforts. Additionally, it introduces the upcoming ECMM Candida IV study, which will focus on assessing candidemia caused by non-albicans Candida species, including Candida auris, investigating antifungal resistance and tolerance, and evaluating novel treatment modalities on a global scale.

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Insights from Three Pan-European Multicentre Studies on Invasive Candida Infections and Outlook to ECMM Candida IV

Wolfgruber,

Sedik,

Klingspor

et al. 2024

Mycopathologia

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show abstract

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Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study

Cited by 1 publication

References 41 publications

Insights from Three Pan-European Multicentre Studies on Invasive Candida Infections and Outlook to ECMM Candida IV

Insights from Three Pan-European Multicentre Studies on Invasive Candida Infections and Outlook to ECMM Candida IV

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