Attractiveness of volatiles from different body parts to the malaria mosquito Anopheles coluzzii is affected by deodorant compounds

Verhulst, Niels O.; Weldegergis, Berhane T.; Menger, David; Takken, Willem

doi:10.1038/srep27141

Cited by 47 publications

(43 citation statements)

References 55 publications

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“…This approach could permit testing and evaluation of fragrance profiles in vivo reducing reliance on expert panels during product development and it could be applied to assessing the retention of fragrance components on skin to ensure integrity of retention in a diverse range of cosmetic products. Moreover, recent evidence has demonstrated the role that deodorant residues may affect the attractiveness of volatile skin emanations to the malaria mosquito Anopheles coluzzii [35]. This highlights the need for further investigation into the impact of cosmetics on the human scent profiles towards development of novel vector control tools.…”

Section: Discussionmentioning

confidence: 99%

Headspace Solid-Phase Microextraction Gas Chromatography-Mass Spectrometry Analysis of Scent Profiles from Human Skin

2018

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Volatile organic compounds (VOCs) emanating from human skin contribute to an individual’s body odour. Understanding the modulation of human odour by a fragrance is of significant importance to the cosmetic sector in the design, development and evaluation of new products. The present research describes an in vivo approach for passive headspace sampling of skin volatile emissions in human participants. A wearable headspace solid-phase microextraction (HS-SPME) method has been employed to investigate baseline endogenous skin volatiles and the subsequent modulation of skin volatile profiles after application of a fragrance to skin. Coupled with gas chromatography-mass spectrometry (GC-MS) this method enables characterisation of scent profiles and fragrance longevity in vivo. A total of 51 compounds were identified in participants’ skin, including 19 endogenous and 32 fragrance-derived compounds. The temporal variation in volatile profiles at different times after fragrance application was investigated. Fragrance diffusion from skin varied between participants resulting in diversified scent profiles over time. This non-invasive approach could be employed during cosmetic product development for in vivo evaluation of fragrance profiles and for assessment of the retention of fragrance components in skin to reduce reliance on expert panels during product development.

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Section: Discussionmentioning

confidence: 99%

Headspace Solid-Phase Microextraction Gas Chromatography-Mass Spectrometry Analysis of Scent Profiles from Human Skin

2018

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“…However, although differences in the attractiveness of volatiles released from different parts of the human body to An . coluzzii may be limited (Dekker et al ., ; Verhulst et al ., ), such differences may vary in other mosquito species and with volatiles from different animals. Nevertheless, differences between animal species are likely to be larger than those within species and among different body sites.…”

Section: Discussionmentioning

confidence: 99%

Variation in host preferences of malaria mosquitoes is mediated by skin bacterial volatiles

Busula

Takken

Boer

et al. 2017

Medical Vet Entomology

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Abstract. The host preferences of the anthropophilic mosquito species in the Anopheles gambiae complex (Diptera: Culicidae) are mediated by skin bacterial volatiles. However, it is not known whether these mosquitoes respond differentially to skin bacterial volatiles from non-human host species. In this study, the responses of two malaria mosquito species in the An. gambiae complex, Anopheles gambiae s.s. (hereafter, An. gambiae) and Anopheles arabiensis, with different host preferences, to volatiles released from skin bacteria were tested. Skin bacteria collected from human, cow and chicken skin significantly increased trap catches; traps containing bacteria collected from human skin caught the highest proportions of An. gambiae and An. arabiensis. Traps with bacteria of human origin caught a significantly higher proportion of An. gambiae than of An. arabiensis, whereas bacterial volatiles from the chicken attracted significantly higher numbers of An. arabiensis than of An. gambiae. Additionally, An. gambiae showed a specialized response to volatiles from four specific bacteria, whereas An. arabiensis responded equally to all species of bacteria tested. Skin bacterial volatiles may therefore play important roles in guiding mosquitoes with different host preferences. The identification of these bacterial volatiles can contribute to the development of an odour blend that attracts mosquitoes with different host preferences.

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“…Assay. A triple-chamber dual-port olfactometer (64) was used to test the preference of 30 5-to 8-d-old female, non-blood-fed An. coluzzii [Suokoko strain, rearing procedures as published (21)] for parasite-free odor or MB5, supplemented with IAC or IAC blends, against background odor alone (parasite-free odor or MB5).…”

Section: Gc-eag Of Pooled Odor Samplesmentioning

confidence: 99%

Plasmodium-associated changes in human odor attract mosquitoes

Robinson

Busula

Voets

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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132

131

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Malaria parasites () can change the attractiveness of their vertebrate hosts to vectors, leading to a greater number of vector-host contacts and increased transmission. Indeed, naturally-infected children have been shown to attract more mosquitoes than parasite-free children. Here, we demonstrate -induced increases in the attractiveness of skin odor in Kenyan children and reveal quantitative differences in the production of specific odor components in infected vs. parasite-free individuals. We found the aldehydes heptanal, octanal, and nonanal to be produced in greater amounts by infected individuals and detected by mosquito antennae. In behavioral experiments, we demonstrated that these, and other,-induced aldehydes enhanced the attractiveness of a synthetic odor blend mimicking "healthy" human odor. Heptanal alone increased the attractiveness of "parasite-free" natural human odor. Should the increased production of these aldehydes by -infected humans lead to increased mosquito biting in a natural setting, this would likely affect the transmission of malaria.

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Attractiveness of volatiles from different body parts to the malaria mosquito Anopheles coluzzii is affected by deodorant compounds

Cited by 47 publications

References 55 publications

Headspace Solid-Phase Microextraction Gas Chromatography-Mass Spectrometry Analysis of Scent Profiles from Human Skin

Headspace Solid-Phase Microextraction Gas Chromatography-Mass Spectrometry Analysis of Scent Profiles from Human Skin

Variation in host preferences of malaria mosquitoes is mediated by skin bacterial volatiles

Plasmodium-associated changes in human odor attract mosquitoes

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