Attitudes towards using topical antimicrobial interventions in wounds “It's not the hole in the patient but the whole of the patient”

Seckam, Abdul; Cooper, Rose; Thirlaway, Kathryn; Mercer, Jenny

doi:10.1016/j.eujim.2012.06.018

Cited by 1 publication

(2 citation statements)

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“…This trend was also observed in day 9 and 12 of treatment period. This phenomenon is discussed by healing, debriding, osmotic, antioxidant and antibacterial properties of honey which was reported previously . Totally honey release in wound bed limits microorganism growth and causes faster wound healing process through growth and proliferation of injured tissue cells.…”

Section: Resultsmentioning

confidence: 99%

“…Honey is used in treatment of many wounds including traumatic wounds, surgical incisions sites, burns, sloughy wounds and pressure ulcers. Many studies were done to investigate bioactiveness of honey which indicate antibacterial activity, debriding action and osmotic effect, anti‐inflammation activity, antioxidant activity, and enhanced rate of healing …”

Section: Introductionmentioning

confidence: 99%

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Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing

Noori

Kokabi

Hassan

2018

J of Applied Polymer Sci

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Many efforts have been made to develop modern wound dressings to overcome limitations of traditional ones. Smart nanocomposite hydrogels are appropriate candidates. In this work, a novel responsive nanocomposite hydrogel based on poly(vinyl alcohol)/chitosan/honey/clay was developed and evaluated as a novel wound dressing. The morphology and properties of synthesized nanocomposite hydrogels loaded with honey as a drug model were investigated. The exfoliated morphology of nanocomposite was confirmed by X-ray diffractometry. Swelling studies were performed at 20 and 37 8C at various pH. The results showed that swelling increased as a result of temperature rise and maximum swelling occurred at a pH of 2. In vitro release of honey was also studied at the same conditions. Corresponding results indicated faster honey release rate at higher pH values. MTT results exhibited no cytotoxicity in nanocomposite hydrogel system. Investigation of antibacterial activity revealed more than 99% antibacterial activity for proposed system. In vivo results confirmed the wound healing ability of developed system. Generally, appropriate properties of proposed system made it ideal in wound dressing applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%