Attitudes Toward Psychological Disorders and Alternative Medicine in Saudi Participants

Alegiry, Mohamed H.; Hajrah, Nahid H.; Alzahrani, Nada A. Y; Shawki, Hossam H.; Khan, M. A.; Zrelli, Houda; Atef, Ahmed; Kim, Young-il; Alsafari, Ibrahim A.; Arfaoui, Leila; Alharby, Hesham F.; Hajar, Abdulrahman S.; El‐Seedi, Hesham R.; Juneja, Lekh Raj; Sabir, Jamal S. M.; Omri, Abdelfatteh El

doi:10.3389/fpsyt.2021.577103

Cited by 3 publications

(3 citation statements)

References 88 publications

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“…This might be due to the presence of apiol in the P. anisum active fraction. It has been reported in previous studies that apiol is a very potent appetite stimulant and also promotes the enzymatic secretions of the digestive tract [30]. From all the above discussions, it is quite clear that the GC-MS analysis reported the presence of oxadiazole compounds in the P. anisum active fraction (P.aAF).…”

Section: Discussionmentioning

confidence: 71%

Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain

Mushtaq

Fatima²,

Manea

et al. 2023

Molecules

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Hundreds of the plants have been explored and evaluated for antioxidant and anti-amnesic activities, so far. This study was designed to report the biomolecules of Pimpinella anisum L. for the said activities. The aqueous extract of dried P. anisum seeds was fractionated via column chromatography and the fractions so obtained were assessed for the inhibition of acetylcholinesterase (AChE) via in vitro analysis. The fraction which best inhibited AChE was so named as the P. anisum active fraction (P.aAF). The P.aAF was then chemically analyzed via GCMS, which indicated that oxadiazole compounds were present in it. The P.aAF was then administered to albino mice to conduct the in vivo (behavioral and biochemical) studies. The results of the behavioral studies indicated the significant (p < 0.001) increase in inflexion ratio, by the number of hole-pokings through holes and time spent in a dark area by P.aAF treated mice. Biochemical studies demonstrated that the oxadiazole present in P.aAF on one hand presented a noteworthy reduction in MDA and the AChE level and on the other hand promoted the levels of CAT, SOD and GSH in mice brain. The LD50 for P.aAF was calculated as 95 mg/Kg/p.o. The findings thus supported that the antioxidant and anticholinesterase activities of P. anisum are due to its oxadiazole compounds.

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Section: Discussionmentioning

confidence: 71%

Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain

Mushtaq

Fatima²,

Manea

et al. 2023

Molecules

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“…and safflower ( Carthamus tinctorius ), suggested 11 times each. Most of the reported plants and herbs have been documented for their psychological properties such as neuroprotective, anxiolytic, antidepressant, and anti-stress features via the inherent phytochemicals and secondary metabolites [ 23 ]. Surprisingly, only 18.8% of the participants agreed that medicinal and aromatic plants could treat psychological disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly, only 18.8% of the participants agreed that medicinal and aromatic plants could treat psychological disorders. Participants (82%) reported that physicians are the most trustful and preferred source of information about alternative and complementary medicine [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

The Use of Safflower (Carthamus tinctorius) in Treating Depression and Anxiety

Albaiz¹

2022

Cureus

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Objective In the era of evidence-based medicine, research in the area of herbal psychopharmacology has increased dramatically in recent decades. To date, however, there is no comprehensive review of safflower as an herbal antidepressant and anxiolytic with details on its psychopharmacology and applications in depression and anxiety. Methods This research is a review and qualitative research through an electronic survey among the Saudi population, thus assessing their knowledge about using safflower in treating depression and anxiety. The survey was distributed in Saudi Arabia in December 2021 and the results were finalized in January 2022. Results A total of 1074 Saudi participants were included in the study; 1002 (93.3%) participants reported knowing safflower very well while 72 (6.7%) had never heard of it. Some participants had used safflower infusions to treat anxiety and depression; 446 (44.4%) participants had never used it, but the remaining 558 (55.6%) had used it to varying degrees to treat anxiety and depression. Among the 752 participants who previously tried safflower, 279 (37.1%) reported that safflower was very effective, 389 (51.73%) reported some improvement, and 93 (12.36%) reported no improvement. Conclusion Emerging medical evidence is guiding herbal treatments. This research illustrates that more than 75% of the Saudi population are using Safflower to treat psychological stress. It elaborates that more than half of the population are already using safflower off the label to treat depression and anxiety and that they find it useful. A well-constructed clinical trial is thus critical to prove the evidence-based benefits of safflower in treating depression and anxiety. More studies on possible side effects are required to guarantee its safety. Nature has previously provided remarkable remedies, and more work will illustrate the value of safflower.

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Antidepressant-Like Effect of Traditional Medicinal Plant Carthamus Tinctorius in Mice Model through Neuro-Behavioral Tests and Transcriptomic Approach

et al. 2022

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Major depression disorder (MDD) has become a common life-threatening disorder. Despite the number of studies and the introduced antidepressants, MDD remains a major global health issue. Carthamus tinctorius (safflower) is traditionally used for food and medical purposes. This study investigated the chemical profile and the antidepressant-like effect of the Carthamus tincto-rius hot water extract in male mice and its mechanism using a transcriptomic analysis. The antidepressant effect of hot water extract (50 mg/kg and 150 mg/kg) was investigated in mice versus the untreated group (saline) and positive control group (fluoxetine 10 mg/kg). Hippocampus transcriptome changes were investigated to understand the Carthamus tinctorius mechanism of action. The GC-MS analysis of Carthamus tinctorius showed that hot water extract yielded the highest amount of oleamide as the most active ingredient. Neuro-behavioral tests demonstrated that the safflower treatment significantly reduced immobility time in TST and FST and improved performance in the YMSAT compared to the control group. RNA-seq analysis revealed a significant differential gene expression pattern in several genes such as Ube2j2, Ncor1, Tuba1c, Grik1, Msmo1, and Casp9 related to MDD regulation in 50 mg/kg safflower treatment as compared to untreated and fluoxetine-treated groups. Our findings demonstrated the antidepressant-like effect of safflower hot water extract and its bioactive ingredient oleamide on mice, validated by a significantly shortened immobility time in TST and FST and an increase in the percentage of spontaneous alternation.

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Attitudes Toward Psychological Disorders and Alternative Medicine in Saudi Participants

Cited by 3 publications

References 88 publications

Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain

Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain

The Use of Safflower (Carthamus tinctorius) in Treating Depression and Anxiety

Antidepressant-Like Effect of Traditional Medicinal Plant Carthamus Tinctorius in Mice Model through Neuro-Behavioral Tests and Transcriptomic Approach

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