Attitudes Toward HIV Pre-Exposure Prophylaxis Among Men Who Have Sex with Men in Western China

Zhang, Yan; Peng, Bin; She, Ying; Liang, Hao; Peng, Hongbin; Qian, Han-Zhu; Vermund, Sten H.; Zhong, Xiaoni; Huang, Aiping

doi:10.1089/apc.2012.0412

Cited by 64 publications

(102 citation statements)

References 11 publications

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“…Previous studies conducted in China observed high proportions of willingness to use PrEP among MSM (11,12). In contrast, we found that less than one-fifth of participants showed their willingness to take TDF on a daily basis for HIV prevention.…”

Section: Discussioncontrasting

confidence: 91%

“…MSM reported more anal sex partners were more willing to participate in the TDF group, consistent with previous studies (11,12,15). This suggests that those with highrisk behaviors were more likely to accept PrEP for HIV prevention.…”

Section: Discussionsupporting

confidence: 88%

“…Earlier studies in China demonstrated that 11.2% to 22% of MSM participants reported having heard of PrEP, and 64% to 91.9% would accept PrEP if available and proved to be safe and effective (11)(12)(13). However, in most of these studies willingness to use was assessed for a future hypothetical PrEP program and therefore the actual acceptance rate of PrEP could not be assessed (11)(12)(13). In this study, we investigated the willingness and actual uptake of PrEP as HIV prevention and associated factors among a sample of HIV-negative MSM in Shanghai, China.…”

Section: Resultsmentioning

confidence: 99%

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Low willingness and actual uptake of pre-exposure prophylaxis for HIV-1 prevention among men who have sex with men in Shanghai, China

Ding

Hong

Zhang

et al. 2016

BST

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Low willingness and actual uptake of pre-exposure prophylaxis for HIV-1 prevention among men who have sex with men in Shanghai, China

Ding

Hong

Zhang

et al. 2016

BST

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“…Significant overlapping transmission risks exist between these populations and PrEP and TasP may be a promising addition to the existing prevention interventions. Increasing awareness about benefits of TasP and PrEP in the community 109,110 and among health care workers 111 are of critical importance. Monitoring such programs will be complex.…”

Section: Discussionmentioning

confidence: 99%

Challenges and potential barriers to the uptake of antiretroviral-based prevention in Asia and the Pacific region

Kato²,

Phanuphak

et al. 2014

Sex. Health

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Abstract. Evidence has emerged over the past few years on the effectiveness of antiretroviral-based prevention technologies to prevent (i) HIV transmission while decreasing morbidity and mortality in HIV-infected persons, and (ii) HIV acquisition in HIV-uninfected individuals through pre-exposure prophylaxis (PrEP). Only few of the planned studies on treatment as prevention (TasP) are conducted in Asia. TasP might be more feasible and effective in concentrated rather than in generalised epidemics, as resources for HIV testing and antiretroviral treatment could focus on confined and much smaller populations than in the generalised epidemics observed in sub-Saharan Africa. Several countries such as Cambodia, China, Thailand and Vietnam, are now paving the way to success. Similar challenges arise for both TasP and PrEP. However, the operational issues for PrEP are amplified by the need for frequent retesting and ensuring adherence. This paper describes challenges for the implementation of antiretroviral-based prevention and makes the case that TasP and PrEP implementation research in Asia is much needed to provide insights into the feasibility of these interventions in populations where firm evidence of 'real world' effectiveness is still lacking.

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“…PrEP is still considered an individual prevention intervention for HIV-negative individuals at a time at which governments struggle to sustain funding for HIV treatment programs, 153 although the increasing HIV incidence among MSM is an argument to include PrEP for HIV prevention for this particular group. 5,7 High-risk individuals in China [154][155][156] and Thailand 157,158 have signaled their acceptance of PrEP if offered. PrEP demonstration projects and effectiveness trials are ongoing in India and Thailand.…”

Section: Preexposure Prophylaxis (Prep) and Microbicidesmentioning

confidence: 99%

HIV Epidemic in Asia: Implications for HIV Vaccine and Other Prevention Trials

Phanuphak

Shao³

et al. 2015

AIDS Research and Human Retroviruses

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An overall decrease of HIV prevalence is now observed in several key Asian countries due to effective prevention programs. The decrease in HIV prevalence and incidence may further improve with the scale-up of combination prevention interventions. The implementation of future prevention trials then faces important challenges. The opportunity to identify heterosexual populations at high risk such as female sex workers may rapidly wane. With unabating HIV epidemics among men who have sex with men (MSM) and transgender (TG) populations, an effective vaccine would likely be the only option to turn the epidemic. It is more likely that efficacy trials will occur among MSM and TG because their higher HIV incidence permits smaller and less costly trials. The constantly evolving patterns of HIV-1 diversity in the region suggest close monitoring of the molecular HIV epidemic in potential target populations for HIV vaccine efficacy trials. CRF01_AE remains predominant in southeast Asian countries and MSM populations in China. This relatively steady pattern is conducive to regional efficacy trials, and as efficacy warrants, to regional licensure. While vaccines inducing nonneutralizing antibodies have promise against HIV acquisition, vaccines designed to induce broadly neutralizing antibodies and cell-mediated immune responses of greater breadth and depth in the mucosal compartments should be considered for testing in MSM and TG. The rationale and design of efficacy trials of combination prevention modalities such as HIV vaccine and preexposure prophylaxis (PrEP) remain hypothetical, require high adherence to PrEP, are more costly, and present new regulatory challenges. The prioritization of prevention interventions should be driven by the HIV epidemic and decided by the country-specific health and regulatory authorities. Modeling the impact and cost-benefit may help this decision process.

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Attitudes Toward HIV Pre-Exposure Prophylaxis Among Men Who Have Sex with Men in Western China

Abstract: Pre-exposure prophylaxis (PrEP), as demonstrated in recently published clinical trials, is one promising approach for controlling the emerging epidemic among men who have sex with men (MSM). We evaluated the attitudes towards use of PrEP among MSM in western China.

Cited by 64 publications

References 11 publications

Low willingness and actual uptake of pre-exposure prophylaxis for HIV-1 prevention among men who have sex with men in Shanghai, China

Low willingness and actual uptake of pre-exposure prophylaxis for HIV-1 prevention among men who have sex with men in Shanghai, China

Challenges and potential barriers to the uptake of antiretroviral-based prevention in Asia and the Pacific region

HIV Epidemic in Asia: Implications for HIV Vaccine and Other Prevention Trials

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