Attitudes in China toward the use of Animals in Laboratory Research

Davey, Gareth; Wu, Zhihui

doi:10.1177/026119290703500305

Cited by 16 publications

(20 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Animals in experimentation index was not affected by country, despite much prominence given to this topic in countries such as the United Kingdom with major laboratory animal activities (eg FRAME 2011). A recent survey has demonstrated considerable concern amongst Chinese people about the use of animals in laboratory research (Davey & Wu 2007). The Iranian score on the Animal rights index and the Unnatural practices on animals index was lowest of any country, and it was also low for the Animal welfare index.…”

Section: Discussionmentioning

confidence: 99%

Students’ attitudes to animal welfare and rights in Europe and Asia

et al. 2012

View full text Add to dashboard Cite

A survey of attitudes towards the welfare and rights of animals was conducted in universities in 11 European and Asian countries, to improve understanding of cultural differences that might impact on trade and international relations. Collaborators' universities were recruited in each country to assist in the design, translation and administration of the survey via the internet in a convenient selection of the country's universities, providing 3,433 student responses from at least 103 universities. Respondents rated the acceptability of 43 major concerns about animals (focused on type of use, animal integrity, killing animals, animal welfare, experimentation on animals, changes in animal genotypes, the environment for animals and societal attitudes towards animals). Students from European countries had more concern for animal welfare than students from Asian countries, which may be partly explained by increased affluence of European students as there was a positive correlation between student expenditure and concern for animal welfare and rights. Southern and central European countries had most concern for animal rights and unnatural practices. Those in communist or former communist countries in Asia and Europe had most concern about killing animals and those in northern European countries the least. Regional similarities between neighbouring countries were evident in responses to animal issues and there were no differences between ethnic groups within a country. Thus, there were national and continental differences in European and Asian students' attitudes to animals' welfare and rights, which appear to arise as a result of the socio-political situation in regions rather than religious or other differences.

show abstract

Section: Discussionmentioning

confidence: 99%

Students’ attitudes to animal welfare and rights in Europe and Asia

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The present study was performed according to the recommendations in the Guide for the Care and Use of Laboratory Animals of China ( 15 ). All animal experiments were performed in accordance with the National Institute of Health, and approved by the Committee on the Ethics of The Third Affiliated Hospital of Kunming Medical University (Kunming, China).…”

Section: Methodsmentioning

confidence: 99%

Tunicamycin suppresses breast cancer cell growth and metastasis via regulation of the protein kinase B/nuclear factor-κB signaling pathway

2018

View full text Add to dashboard Cite

Breast cancer is one of the most common metastatic tumor types. Reports have suggested that Tunicamycin may inhibit the aggressiveness of cancer cells by promoting their apoptosis. In the present study, the inhibitory effects of Tunicamycin were investigated and the potential molecular mechanism underlying the Tunicamycin-inhibited growth and aggressiveness of breast cancer cells was explored. In vitro assays demonstrated that Tunicamycin significantly inhibited growth and arrested the cell cycle of breast cancer cells in a dose-dependent manner, compared with control cells. Results revealed that Tunicamycin treatment suppressed the migration and invasion of breast cancer cells. Significantly increased apoptosis of breast cancer cells was observed subsequent to Tunicamycin treatment, as compared with control cells. Mechanism analysis demonstrated that Tunicamycin inhibited the protein kinase B (Akt) and nuclear factor-κB (NF-κB) signaling pathways, whilst Akt overexpression significantly cancelled out the Tunicamycin-inhibited growth and aggressiveness of breast cancer cells, as compared with control cells. In vivo assays revealed that Tunicamycin treatment significantly inhibited tumor growth and significantly prolonged the survival of tumor-bearing mice, compared with the PBS-treated group. In conclusion, these results indicate that Tunicamycin may inhibit the growth and aggressiveness of breast cancer cells via regulation of the Akt/NF-κB signaling pathway.

show abstract

“…Symptoms of ulcerative colitis in rats were observed on days 0 and 30 as described previously (19). The present study was performed in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of China (20). All surgical procedures were approved by the Committee on the Ethics of Tianjin Medical University General Hospital (Tianjin, China).…”

Section: Methodsmentioning

confidence: 99%

Costus root granules improve ulcerative colitis through regulation of TGF-β mediation of the PI3K/AKT signaling pathway

Wang

Zhang

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Ulcerative colitis is a chronic nonspecific inflammatory disease that occurs in the colon and rectum. Costus root is a type of traditional Chinese medicine that exhibits antibacterial properties and serves an inhibitory role in the regeneration of gut bacteria. However, the molecular mechanisms underlying Costus root-mediated improvements in ulcerative colitis remain unclear. A complex formula of Costus root granules was created and investigated in the present study for its therapeutic effects in a rat model of ulcerative colitis. Ingredient dissolution into a traditional water decoction was used as a control. The potential mechanism mediated by Costus root granules was also analyzed in colonic epithelial cells isolated from the experimental rats. The results of the present study demonstrated that Costus root granule treatment inhibited inflammation in colonic tissue. Costus root granule treatment also suppressed the apoptosis of colonic epithelial cells isolated from the rat model of ulcerative colitis. Analyses of the underlying mechanisms of these effects indicated that the administration of Costus root granules increased transforming growth factor β expression, which activated the phosphoinositide 3-kinase/RAC-α serine/threonine-protein kinase signaling pathway in colonic epithelial cells. Notably, the administration of Costus root granules improved stomachache, diarrhea and hematochezia in and increased the body weight of, the ulcerative colitis rats. In conclusion, these results indicate that Costus root granules markedly ameliorate inflammation of the colonic epithelium, decrease the apoptosis of colonic epithelial cells and improve colonic function, which suggests that Costus root granules are an efficient agent for the treatment of ulcerative colitis.

show abstract

Attitudes in China toward the use of Animals in Laboratory Research

Cited by 16 publications

References 3 publications

Students’ attitudes to animal welfare and rights in Europe and Asia

Students’ attitudes to animal welfare and rights in Europe and Asia

Tunicamycin suppresses breast cancer cell growth and metastasis via regulation of the protein kinase B/nuclear factor-κB signaling pathway

Costus root granules improve ulcerative colitis through regulation of TGF-β mediation of the PI3K/AKT signaling pathway

Contact Info

Product

Resources

About