Attitudes about genetic testing and genetic testing intentions in African American women at increased risk for hereditary breast cancer

Kessler, Lisa; Collier, Aliya; Brewster, Kiyona; Smith, Cara Lea; Weathers, Benita; Wileyto, E. Paul; Halbert, Chanita Hughes

doi:10.1097/01.gim.0000159901.98315.fe

Cited by 54 publications

(71 citation statements)

References 26 publications

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“…This is in contrast to studies of African American women, which have found that cancer-specific fatalism is higher among those considering BRCA testing [72] and those who participate in GCRA and receive BRCA test results [73]. In our study, cancer-specific fatalism was lower in individuals who were more self-efficacious.…”

Section: Discussioncontrasting

confidence: 99%

Social‐cognitive aspects of underserved Latinas preparing to undergo genetic cancer risk assessment for hereditary breast and ovarian cancer

et al. 2008

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Objectives: As Latinos are a growing ethnic group in the United States, it is important to understand the socio-cultural factors that may be associated with cancer screening and prevention in this population. The socio-cultural factors that may affect preparedness to undergo genetic cancer risk assessment (GCRA) deserve particular attention. The pre-GCRA period can provide insight into variables that may influence how medically underserved Latinas, with limited health resources and access, understand hereditary cancer information and subsequently implement cancer risk management recommendations. This study explores social, cognitive and cultural variables in Latinas prior to undergoing GCRA.Methods: The study sample consisted of low-income, underserved Latinas referred for GCRA because of a personal and/or family history of breast or ovarian cancer. Acculturation, cancer-specific fatalism, self-efficacy and social support were assessed prior to GCRA.Results: Fifty Latinas (mean age 5 40.177.7) completed instruments; 86% had invasive cancer, 78% spoke primarily Spanish and 61% were of Mexican ancestry. Low levels of acculturation (n 5 50, mean 5 9.075.8) and cancer-specific fatalism (n 5 43, mean 5 5.673.2), but relatively high self-efficacy (n 5 49, mean 5 40.977.8) and social support (n 5 49, mean 5 37.378.7) were reported. Cancer-specific fatalism and self-efficacy were inversely correlated (r 5 À0.47, p 5 0.002). Those over age 38 at the time of cancer diagnosis reported higher acculturation (mean 5 11.477.2, p 5 0.02) and social support (mean 5 40.571.2, p 5 0.05).Conclusions: These findings suggest that medically underserved Latinas may already possess some of the necessary skills to successfully approach the GCRA process, but that special attention should be given to cultural factors.

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Section: Discussioncontrasting

confidence: 99%

Social‐cognitive aspects of underserved Latinas preparing to undergo genetic cancer risk assessment for hereditary breast and ovarian cancer

et al. 2008

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“…Furthermore, although about 15% African American women recruited from urban health care facilities believed that genetic testing would be used to show that their ethnic group is inferior, this belief was not reported by Caucasian women (23). However, consistent with prior studies (9,10,19), attitudes about the benefits of genetic testing for smoking susceptibility were endorsed at a higher rate relative to limitations and risks in this study. Despite this, respondents who reported greater perceptions of limitations and risks were less likely to be willing to participate in research on genetics and smoking.…”

Section: Discussionsupporting

confidence: 79%

“…Specifically, respondents were asked ''how likely is it that you would participate in a research study designed to identify genetic risk factors for smoking'' (1 = not at all likely, 4 = very likely). Similar items have been used to evaluate genetic testing intentions for lung cancer susceptibility and other diseases among African American men and women (14,(19)(20)(21).…”

Section: Outcome Variablementioning

confidence: 99%

Intentions to Participate in Genetics Research among African American Smokers

Halbert¹,

Gandy

Collier³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Although prior studies have shown that African American smokers are likely to carry some of the genetic variants associated with smoking risk, additional research with African American smokers is needed to replicate these findings. Limited information is available on interest in participating in research to identify genetic risk factors for smoking among African American smokers; therefore, the goals of the present study were to describe intentions to participate in smoking and genetics research, and to determine factors that are associated with participation intentions. Subjects were 128 African American male and female adult smokers. Sociodemographic characteristics, clinical factors, attitudes about genetic testing, and intentions to participate in genetics research were evaluated during a structured telephone interview. Overall, 58% of respondents reported that they would be very likely to participate in research to identify genetic risk factors for smoking. Greater beliefs about the benefits of participating in medical research (odds ratio, 3.17; 95% confidence interval, 1.45-6.94; P = 0.004) and fewer perceptions of the limitations and risks of genetic testing (odds ratio, 0.90; 95% confidence interval, 0.82-0.98; P = 0.01) had significant independent associations with reporting a high likelihood of participating in this type of research. Recruitment messages and protocols that address the benefits of research participation, as well as concerns about the limitations and risks of genetic testing, may enhance African American participation in research on genetics and smoking.

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“…Previous research evaluating the association between risk and perceived benefits and barriers has been inconsistent. Some studies indicate that greater perceived cancer risk is associated with greater perceived barriers to genetic testing and skepticism about the utility of genetic tests (18,19). However, studies examining other health behaviors indicate that greater perceived risk is associated with greater perceived benefits of risk-reducing behaviors (20).…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Attitudes about Microsatellite Instability Testing among High-Risk Individuals Diagnosed with Colorectal Cancer

Manne

Chung

Weinberg

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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For individuals meeting Bethesda criteria for hereditary nonpolyposis colorectal cancer syndrome, the microsatellite instability (MSI) test is recommended as a screening evaluation before proceeding to genetic testing. The MSI test is new to the medical setting, but will be increasingly used to screen patients at high risk for hereditary nonpolyposis colorectal cancer. The main goals of this study were to examine knowledge about and exposure to the MSI test among individuals considering the test, to evaluate perceived benefits and barriers to undergoing the MSI test, and to identify the demographic, medical, and psychosocial correlates of the perceived benefits and barriers to undergoing the test. One hundred and twenty-five patients completed a survey after being offered the test, but prior to making the decision whether to pursue MSI testing. Results indicated low levels of knowledge about and previous exposure to the MSI test. Participants held positive attitudes about the potential benefits of the test and perceived few barriers to undergoing the test. Motivations were similar to those cited by individuals considering other genetic tests. Participants with nonmetastatic disease, with lower perceived risk for cancer recurrence, and who reported more self-efficacy endorsed more benefits from the test. Higher levels of cancer-specific psychological distress were associated with more perceived barriers to having the test. These findings suggest that individuals considering the MSI test know very little about it but hold positive attitudes about the test's utility. More distressed patients, patients who perceive themselves at higher risk for cancer recurrence, and patients with metastatic disease might be less motivated to have the MSI test.

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Attitudes about genetic testing and genetic testing intentions in African American women at increased risk for hereditary breast cancer

Cited by 54 publications

References 26 publications

Social‐cognitive aspects of underserved Latinas preparing to undergo genetic cancer risk assessment for hereditary breast and ovarian cancer

Social‐cognitive aspects of underserved Latinas preparing to undergo genetic cancer risk assessment for hereditary breast and ovarian cancer

Intentions to Participate in Genetics Research among African American Smokers

Knowledge and Attitudes about Microsatellite Instability Testing among High-Risk Individuals Diagnosed with Colorectal Cancer

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