Attenuation of γ-aminobutyric acid (GABA) transaminase activity contributes to GABA increase in the cerebral cortex of mice exposed to β-cypermethrin

Ye, Han; Cao, Dezhi; Li, X; Zhang, R; Yu, Fei; Ren, Yi; Liu, An

doi:10.1177/0960327113497770

Cited by 11 publications

(5 citation statements)

References 25 publications

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“…The results of the present study supported the previous theory; there was statistically significant decrease in mean brain GABA concentration of CYP-treated group in comparison to control group. This result is in 29 agreements with Kumar et al [5] & Manna et al, [30] who stated that CYP leading to significant decrease in GABA level. This result is against Han et al [31] who stated that increased level of the GABA was detected in the cerebral cortex of mice exposed to CYP in a dose of (20 mg/kg).…”

Section: Discussionsupporting

confidence: 91%

Amira Ebrahim Alsemeh, Mohamed A. M. AbdelRahman, Fatma A. Mahmoud, Eman Ramadan Abd El Fattah

Alsemeh

Abdel-Rahman

Mahmoud

et al. 2020

Journal of Medical Histology

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Cypermethrin (CYP) is a synthetic pyrethroid. It crosses the blood-brain barrier in pests and creates neurotoxicity in the CNS. Hydroxytyrosol (HT) is considered a powerful natural antioxidant, it is found in olive leaf, olive pulp and olive oil. Hydroxytyrosol is the only phenol that is capable to pass the blood-brain barrier and permits it to involve free radicals throughout the CNS. We designed this study to explore the possible protective role of HT against the neurotoxic effect induced by CYP. Thirty male adult albino rats were divided into three groups. Control group; subdivided into: control, corn oil, HT groups, CYP treated and CYP, CYP+ HT treated group. Treatments were given by gavage for 14 days. The cerebrum tissue was prepared for histopathological examination and immunohistochemical detection of caspase 3 and GFAP. We also assessed the level of GAPA and ACH in the tissue and the oxidative enzymatic and the lipid perioxidation profile. We observed that the concomitant use of HT with the CYP diminished the signs of hyper excitability induced by the CYP which confirmed by significant decrease in the level of GABA in cerebrum tissue. HT counteracted the histopathological changes induced by CYP and significantly downregulated the caspase -3 and GFAP expression in cerebrum tissue. A rescue of the oxidative enzymatic activity, lipid peroxidation profiles was also evident in the CYP+HT-treated group. We concluded that HT exhibited substantial antioxidant and anti-apoptotic impacts on the cerebral cortex cytomorphological alterations and apoptosis produced by CYP in cerebrum tissue.

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Section: Discussionsupporting

confidence: 91%

Amira Ebrahim Alsemeh, Mohamed A. M. AbdelRahman, Fatma A. Mahmoud, Eman Ramadan Abd El Fattah

Alsemeh

Abdel-Rahman

Mahmoud

et al. 2020

Journal of Medical Histology

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“…Other paper found that AVM would cause twitching and keep exciting in bees; this may relate to the fact that AVM inhibits the expressions of GAD and GABA-T in the cerebellum (Zhao et al 2014). Besides, deltamethrin and β-cypermethrin could downregulate GABA-T level in the cerebral cortex of rats, which resulting in an increase in GABA level (Ji et al 2003;Han et al 2014). All the evidences mentioned above suggested that AVM would break through the blood-brain barrier, which lead to the increase of GABA through affecting the mRNA expressions of GAD 65 , GAD 67 , and GABA-T in crucian carp's nervous system.…”

Section: Discussionmentioning

confidence: 99%

Effects of two kinds of fishery drugs on the expressions of GAD and GABA-T mRNA in crucian carp (Carassius auratus gibelio)

Zhang

Huang

et al. 2020

Fish Physiol Biochem

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The objective of this study was to investigate the effects of difloxacin (DIF) and avermectin (AVM) on glutamate decarboxylase (GAD) and GABA-transaminase (GABA-T) in different tissues of crucian carp (Carassius auratus gibelio). After the treatments of DIF and AVM, the mRNA expressions of GAD and GABA-T in different tissues were detected by quantitative real-time PCR (qPCR). The results showed that the mRNA expressions of GAD65, GAD67, and GABA-T in the telencephalon (Tel), mesencephalon (Mes), cerebella (Cer), and medulla oblongata (Med) were downregulated significantly with the safe dose (SD, 20 mg/kg) of DIF (P < 0.05 or P < 0.01). While the expressions of GAD65 and GAD67 in the kidney at 12 h had strikingly upregulated to 13.81 ± 1.06** and 150.67 ± 12.85** times. Treated with the lethal dose of 50% (LD50, 2840 mg/kg b. W.) of DIF, the mRNA expressions of GAD65, GAD67, and GABA-T in all tissues were increased significantly (P < 0.01). The results of AVM group showed that the mRNA expressions of GAD65, GAD67, and GABA-T both in the central and peripheral tissues were all remarkably downregulated at the safe concentration (SC, 0.0039 mg/L) and the lethal concentration of 50% (LC50, 0.039 mg/L), except for the mRNA inhibitions of GAD65, GAD67, and GABA-T in the muscle at 2 h which sharply downregulated to 0.20 ± 0.02ΔΔ × 10−2, 0.57 ± 0.06ΔΔ × 10−1 and 0.44 ± 0.02ΔΔ × 10−1, respectively (P < 0.01).

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“…γ-amino butyric acid (GABA) is the brain’s major inhibitory neurotransmitter, and inhibitory neurotransmission abnormalities have been linked to ASD [56–61]. There are two major types of GABA receptors, GABAA and GABAB.…”

Section: Neurobiological Basis For Social Deficits In Asdmentioning

confidence: 99%

“…Animal studies have also been performed to further study GABAA in ASD. Enhancement of GABAA action has been shown to reverse behavioral deficits in a mouse model of ASD [61], while reduction in GABAA signaling exacerbates deficits [61]. …”

Section: Neurobiological Basis For Social Deficits In Asdmentioning

confidence: 99%

See 1 more Smart Citation

The Neurobiological Basis for Social Affiliation in Autism Spectrum Disorder and Schizophrenia

Crider

Pillai

2016

Curr Behav Neurosci Rep

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Social interaction and communication are complex behavioral paradigms involving many components. Many different neurotransmitters, hormones, sensory inputs, and brain regions are involved in the act of social engagement and verbal or nonverbal communication. Autism Spectrum Disorder (ASD) and schizophrenia are two neurodevelopmental disorders that have social and language deficits as hallmark symptoms, but show very different etiologies. The output of social dysfunction is common to both ASD and schizophrenia, but this likely arises from very different pathophysiological means. This review will attempt to compile and interpret human and animal studies showing the neurobiological basis for the development of social and language deficits in ASD and schizophrenia as well as a comparison of the two disorders.

show abstract

Attenuation of γ-aminobutyric acid (GABA) transaminase activity contributes to GABA increase in the cerebral cortex of mice exposed to β-cypermethrin

Cited by 11 publications

References 25 publications

Amira Ebrahim Alsemeh, Mohamed A. M. AbdelRahman, Fatma A. Mahmoud, Eman Ramadan Abd El Fattah

Amira Ebrahim Alsemeh, Mohamed A. M. AbdelRahman, Fatma A. Mahmoud, Eman Ramadan Abd El Fattah

Effects of two kinds of fishery drugs on the expressions of GAD and GABA-T mRNA in crucian carp (Carassius auratus gibelio)

The Neurobiological Basis for Social Affiliation in Autism Spectrum Disorder and Schizophrenia

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