Attenuation of the severity and changes in the microbiota in an animal model of primary biliary cholangitis by FOXP3⁻ regulatory T cells

Abstract

Treg/B cells attenuated the inflammation, reduced liver fibrosis, and changed faecal microbial diversities in the PBC animal model. • Treg/B cells modulated the maturation of bone marrow-derived dendritic cells partially through the CTLA-4 pathway. • Treg/B cells might be a potential therapy for autoimmune liver disease.