Attenuation of the Heartbeat-Evoked Potential in Patients With Atrial Fibrillation

Kumral, Deniz; Al, Esra; Cesnaite, Elena; Kornej, Jelena; Sander, Christian; Hensch, Tilman; Zeynalova, Samira; Tautenhahn, S; Hagendorf, Andreas; Laufs, Ulrich; Wachter, Rolf; Nikulin, Vadim V.; Villringer, Arno

doi:10.1016/j.jacep.2022.06.019

Cited by 14 publications

(19 citation statements)

References 26 publications

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“…HERs have been shown as potential biomarkers reflecting cognitive and interoceptive impairments under a diversity of neurodegenerative conditions 27,28 . Our results confirm and highlight the importance of studying brain-heart interactions under cardiac pathologies, such as the recently observed reduction of HERs in patients suffering atrial fibrillation 29 and cardiac arrest 30 . The understanding of the mechanisms of brain-heart interactions will contribute to the acknowledged potential of EEG for prognostication in post-comatose conditions related to cardiac failures [31][32][33][34] .…”

Section: Discussionsupporting

confidence: 86%

“…EEG spectrogram was computed using short-time Fourier transform with a sliding time window of 2 s with a 50% overlap. Time-varying EEG oscillations were integrated within the ranges delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and gamma (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45).…”

Section: Participantmentioning

confidence: 99%

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Changes in the heartbeat-evoked potential under ventricular fibrillation: a near-death case report

Candia-Rivera¹,

Machado²

2023

Preprint

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Background & Purpose: Whether brain-heart communication continues under ventricular fibrillation (VF) remains to be acknowledged. There is limited evidence of the physiological changes in cortical activity under VF. Moreover, brain-heart communication has not been studied before in this condition. We aim to illustrate parallel changes in heart-rate variability, cortical activity, and brain-heart interactions in a case report undergoing VF. Methods: The case report's EEG and EKG was acquired for approximately 20h. We selected different one-minute-long segments, based on the changes in the EKG waveform. We present the changes in heartbeat-evoked responses (HERs), heart rate variability (HRV), and EEG power for each selected segment.Results: The overall physiological activity appears deteriorated in the ongoing VF. Brain-heart interactions measured with HERs disappear, with a few aberrant amplitudes appearing occasionally. The parallel changes in EEG-HRV are not pronounced, suggesting an absence of bidirectional neural control.Conclusions: The measurements of brain-heart interactions suggest that the evolving VF causes deteriorated communication between the central and autonomic nervous systems. These results may support that reduced brain-heart interactions reflect the loss of consciousness and overall health state.

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Section: Discussionsupporting

confidence: 86%

Section: Participantmentioning

confidence: 99%

Changes in the heartbeat-evoked potential under ventricular fibrillation: a near-death case report

Candia-Rivera¹,

Machado²

2023

Preprint

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“…The study which addressed the association between HEPs and survival after cardiac arrest indicated that HEP amplitudes at frontopolar and frontal electrodes were negatively related to mortality ( Schulz et al, 2018 ). In nightmare sufferers or patients with atrial fibrillation, significant negative clusters of HEP over the frontal lobe channels were observed with lower amplitudes in groups with patients compared to those of healthy controls ( Perogamvros et al, 2019 ; Kumral et al, 2022 ). Since HEP is usually regarded as an objective electrophysiological biomarker of brain-heart interactions ( Park & Blanke, 2019 ; Coll et al, 2021 ), the reduction of HEP amplitude suggests an attenuation of brain-heart coupling due to the pathological state.…”

Section: Discussionmentioning

confidence: 92%

“…Heartbeat evoked potential (HEP), which pertains to the cortical processing of afferent signals from the cardiovascular system, has been considered a neurophysiological indicator of interoception ( Schulz et al, 2018 ). It is an EEG event-related potential obtained by averaging EEG signals time-locked to the R-peak or T-peak of simultaneous ECG recording ( Kumral et al, 2022 ). The amplitude of HEP, linked to the phase of neural activity, reflects a synchronization or strength of brain-heart coupling based on afferent and efferent pathways ( Tumati et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Enhanced external counterpulsation modulates the heartbeat evoked potential

Liu

Hui

et al. 2023

Front. Physiol.

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Introduction: Accumulating evidence suggests that enhanced external counterpulsation (EECP) influences cardiac functions, hemodynamic characteristics and cerebral blood flow. However, little is known about whether or how the EECP affects the brain-heart coupling to produce these physiological and functional changes. We aimed to determine if the brain-heart coupling is altered during or after EECP intervention by assessing the heartbeat evoked potential (HEP) in healthy adults.Methods: Based on a random sham-controlled design, simultaneous electroencephalography and electrocardiography signals as well as blood pressure and flow status data were recorded before, during and after two consecutive 30-min EECP in 40 healthy adults (female/male: 17/23; age: 23.1 ± 2.3 years). HEP amplitude, frequency domain heart rate variability, electroencephalographic power and hemodynamic measurements of 21 subjects (female/male: 10/11; age: 22.7 ± 2.1 years) receiving active EECP were calculated and compared with those of 19 sham control subjects (female/male: 7/12; age: 23.6 ± 2.5 years).Results: EECP intervention caused immediate obvious fluctuations of HEP from 100 to 400 ms after T-peak and increased HEP amplitudes in the (155–169) ms, (354–389) ms and (367–387) ms time windows after T-peak in the region of the frontal pole lobe. The modifications in HEP amplitude were not associated with changes in the analyzed significant physiological measurements and hemodynamic variables.Discussion: Our study provides evidence that the HEP is modulated by immediate EECP stimuli. We speculate that the increased HEP induced by EECP may be a marker of enhanced brain-heart coupling. HEP may serve as a candidate biomarker for the effects and responsiveness to EECP.

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“…Кардиоваскулярная терапия и профилактика. 2022;21 В недавно опубликованном исследовании [65] было показано, что амплитуда ВСП в группе пациентов с персистирующей формой ФП (n=56) снижена по сравнению с группой контроля (n=56), сопоставимой по возрасту, полу, индексу массы тела. Интересно, что различия в амплитуде сохранялись после поправки на параметры сердечной деятельности (ударный объем, АД, продолжительность RR-интервала), а также после исключения из анализа пациентов с сопутствующими ССЗ (сердечная недостаточность, ИМ и операция коронарного шунтирования в анамнезе).…”

Section: результатыunclassified

Neurovisceral interactions within the brain-heart axis as the basis of neurocardiology

Лимонова¹,

Germanova

Gantman

et al. 2022

Cardiovasc Ther Prev

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The use of a systematic approach to the study of the etiology of a certain pathology makes it possible to improve the understanding of its pathogenesis, as well as to develop more effective diagnostic and therapeutic approaches, including improving the prediction of its risk. Within this review, we will consider such an area of interdisciplinary research as neurocardiology, which studies the brain-heart axis. Examples of cardiovascular diseases associated with organic and functional disorders of this axis will be considered, as well as the prospects for research in this area and their translational significance for clinical medicine.

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Attenuation of the Heartbeat-Evoked Potential in Patients With Atrial Fibrillation

Cited by 14 publications

References 26 publications

Changes in the heartbeat-evoked potential under ventricular fibrillation: a near-death case report

Changes in the heartbeat-evoked potential under ventricular fibrillation: a near-death case report

Enhanced external counterpulsation modulates the heartbeat evoked potential

Neurovisceral interactions within the brain-heart axis as the basis of neurocardiology

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