Attenuation of the disruptive effects of (+/-)3,4-methylene dioxymethamphetamine (MDMA) on delayed matching-to-sample performance in the rat.

Harper, David N.; Hunt, Maree; Schenk, Susan

doi:10.1037/0735-7044.120.1.201

Cited by 26 publications

(32 citation statements)

References 25 publications

(47 reference statements)

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“…Indeed, accuracy of responding remained quite high across all doses of MDMA in both the OST and SD conditions. This account is consistent with previous findings from Harper (2005, 2006) that MDMA-induced errors can be attenuated by increasing the discriminability of relevant cues and more general findings that behavior under strong stimulus control is less sensitive to drug effects (Katz, 1982; 1983). Such an account is also consistent with more general notions about the role of task difficulty in its sensitivity to MDMA in human populations (e.g.…”

Section: Discussionsupporting

confidence: 92%

Effects of MDMA on olfactory memory and reversal learning in rats

Hawkey

April

Galizio

2014

Neurobiology of Learning and Memory

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The effects of acute and sub-chronic MDMA were assessed using a procedure designed to test rodent working memory capacity: the odor span task (OST). Rats were trained to select an odor that they had not previously encountered within the current session, and the number of odors to remember was incremented up to 24 during the course of each session. In order to separate drug effects on the OST from more general performance impairment, a simple olfactory discrimination was also assessed in each session. In Experiment 1, acute doses of MDMA were administered prior to select sessions. MDMA impaired memory span in a dose-dependent fashion, but impairment was seen only at doses (1.8 and 3.0 mg/kg) that also increased response omissions on both the simple discrimination and the OST. In Experiment 2, a sub-chronic regimen of MDMA (10.0 mg/kg, twice daily over four days) was administered after OST training. There was no evidence of reduced memory span following sub-chronic MDMA, but a temporary increase in omission errors on the OST was observed. In addition, rats exposed to sub-chronic MDMA showed delayed learning when the simple discrimination was reversed. Overall, the disruptive effects of both acute and sub-chronic MDMA appeared to be due to non-mnemonic processes, rather than effects on specific memory functions.

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Section: Discussionsupporting

confidence: 92%

Effects of MDMA on olfactory memory and reversal learning in rats

Hawkey

April

Galizio

2014

Neurobiology of Learning and Memory

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“…The conclusions of the above studies were that acute MDMA results in working memory impairments. However, it has been argued that these findings do not involve working memory effects, but rather reflect disruptions of reference memory involving the rules or strategies associated with a given task (Harper et al, 2005; 2006; Kay et al, 2010). As an illustration, Kay et al (2010) used a version of the radial arm maze designed to separate working and reference memory and found that MDMA had no effect on the working memory task (arms were always baited for one visit), but impaired the reference memory task (arms that were never baited throughout the experiment).…”

Section: Discussionmentioning

confidence: 99%

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

et al. 2014

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Acute effects of methylenedioxymethamphetamine (MDMA), methamphetamine (MA) and methylphenidate (MPD) were studied using a within-subject, repeated acquisition/performance procedure adapted to the Morris Swim Task. To investigate place learning, the acquisition component consisted of a hidden platform that varied in location across experimental sessions. As a control for drug effects not specific to acquisition, a performance component was included in which the hidden platform was in the same pool location in every experimental session. All three drugs increased escape latencies and swim distances in dose-dependent fashion. However, impairment in the acquisition component was generally observed only at doses that also produced impairment in the performance component, suggesting that effects were not selective to place learning. None of the drugs produced enhancement of learning or performance at any dose. Taken together, the results suggest that acute exposure to these psychomotor stimulants produce global impairment of performance in the Morris task, rather than specific deficits in place learning.

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“…Although delayed matching-to-position procedures are frequently used in rodent studies of working memory [39], we modified the task so that rats were required to press the rear-lever during the retention interval [40]. This rendered the task closer to the NIMH [36] definition of working memory, as rats had to actively maintain task relevant information while completing the rear-lever task that may interfere with this maintenance.…”

Section: Methodsmentioning

confidence: 99%

Impulsive Choice Predicts Poor Working Memory in Male Rats

2014

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A number of maladaptive behaviors and poor health outcomes (e.g., substance abuse, obesity) correlate with impulsive choice, which describes the tendency to prefer smaller, immediate rewards in lieu of larger, delayed rewards. Working memory deficits are often reported in those diagnosed with the same maladaptive behaviors. Human studies suggest that impulsive choice is associated with working memory ability but, to date, only one study has explored the association between working memory and impulsive choice in rats and no relation was reported. The current study reevaluated the association between working memory and impulsive choice in 19 male Long-Evans rats. Psychophysical adjusting procedures were used to quantify working memory (titrating-delay match-to-position procedure) and impulsive choice (adjusting delay procedure). Rats were partitioned into low- and high-impulsive groups based on performance in the impulsive choice task. Low-impulsive rats performed significantly better in the working memory assessment. Across all rats, impulsive choice was negatively correlated with working memory performance. These findings support the hypothesis that prefrontal cortex function, specifically, working memory, is related to impulsive choice. Future research might profitably examine the experimental variables designed to influence working memory to evaluate the effects of these variables on impulsive choice and maladaptive behaviors with which it is correlated.

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Attenuation of the disruptive effects of (+/-)3,4-methylene dioxymethamphetamine (MDMA) on delayed matching-to-sample performance in the rat.

Cited by 26 publications

References 25 publications

Effects of MDMA on olfactory memory and reversal learning in rats

Effects of MDMA on olfactory memory and reversal learning in rats

Repeated Acquisition in the Morris Swim Task: Effects of Methylenedioxymethamphetamine, Methamphetamine, and Methylphenidate

Impulsive Choice Predicts Poor Working Memory in Male Rats

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