Attenuation of sodium arsenite mediated ovarian DNA damage, follicular atresia, and oxidative injury by combined application of vitamin E and C in post pubertal Wistar rats

Mondal, Rubia; Pal, Priyankar; Biswas, Sagnik; Chattopadhyay, Alok; Bandyopadhyay, A. K.; Mukhopadhyay, Aparna; Mukhopadhyay, P. K.

doi:10.1007/s00210-023-02491-9

Cited by 4 publications

(1 citation statement)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research has shown that multiple antioxidants can restore mitochondrial function by reducing ROS production and stimulating antioxidant production. It mainly includes coenzyme Q10 ( 177 ), vitamin E ( 164 ), vitamin C ( 164 ), L-carnitine ( 165 , 166 ), melatonin ( 167 , 168 ), quercetin ( 169 ), resveratrol ( 170 ), astaxanthin ( 171 ), and ginsenoside Rb1 ( 44 ).…”

Section: Methods To Slow Down Ovarian Aging and Prolong Reproductive ...mentioning

confidence: 99%

Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions

Ju,

Zhao,

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

Mitochondria plays an essential role in regulating cellular metabolic homeostasis, proliferation/differentiation, and cell death. Mitochondrial dysfunction is implicated in many age-related pathologies. Evidence supports that the dysfunction of mitochondria and the decline of mitochondrial DNA copy number negatively affect ovarian aging. However, the mechanism of ovarian aging is still unclear. Treatment methods, including antioxidant applications, mitochondrial transplantation, emerging biomaterials, and advanced technologies, are being used to improve mitochondrial function and restore oocyte quality. This article reviews key evidence and research updates on mitochondrial damage in the pathogenesis of ovarian aging, emphasizing that mitochondrial damage may accelerate and lead to cellular senescence and ovarian aging, as well as exploring potential methods for using mitochondrial mechanisms to slow down aging and improve oocyte quality.

show abstract

Section: Methods To Slow Down Ovarian Aging and Prolong Reproductive ...mentioning

confidence: 99%

Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions

Ju,

Zhao,

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Impact of oxidative stress induced by heavy metals on ovarian function

Xiao,

Lai

2024

J of Applied Toxicology

View full text Add to dashboard Cite

As a crucial organ of the female reproductive system, the ovary has both reproductive and endocrine functions. Oxidative stress refers to an increase in intracellular reactive oxygen species (ROS), which play a role in the normal physiological activity of the ovary. However, excessive ROS can cause damage to the ovary. With the advancement of human industrial activities, heavy metal pollution has become increasingly severe. Heavy metals cause oxidative stress through both direct and indirect mechanisms, leading to changes in signal transduction pathways that damage the ovaries. This review aims to outline the adverse effects of oxidative stress on the ovaries triggered by heavy metals such as copper, arsenic, cadmium, mercury, and lead. The detrimental effects of heavy metals on ovaries include follicular atresia and decreased estrogen production in experimental animals, and they also cause premature ovarian insufficiency in women. Additionally, this review discusses the role of antioxidants, provides some treatment methods, summarizes the limitations of current research, and offers perspectives for future research directions.

show abstract

Effect of Gentianella acuta (Michx.) Hulten against the arsenic-induced development hindrance of mouse oocytes

Wang,

Wei

et al. 2024

Biometals

View full text Add to dashboard Cite

Attenuation of sodium arsenite mediated ovarian DNA damage, follicular atresia, and oxidative injury by combined application of vitamin E and C in post pubertal Wistar rats

Cited by 4 publications

References 102 publications

Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions

Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions

Impact of oxidative stress induced by heavy metals on ovarian function

Effect of Gentianella acuta (Michx.) Hulten against the arsenic-induced development hindrance of mouse oocytes

Contact Info

Product

Resources

About