Attenuation of obesity-induced inflammation in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent

Hirose, Shouhei; Asano, Kozo; Nakane, Akio

doi:10.1016/j.bbrc.2017.01.056

Cited by 13 publications

(19 citation statements)

References 24 publications

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“…4). Therefore, prolonged survival of the grafts in PG-administered mice may be due to inhibition of phagocyte recruitment through suppression of IL-17-induced chemokines, as shown in other mouse inflammatory models (11)(12)(13)(14). To support this hypothesis, further evaluations of phagocytes, Th17 cells, IL-17, as well as other associated chemokines are required.…”

Section: Discussionmentioning

confidence: 90%

“…Attenuation of the systemic inflammation in colitis and EAE models by daily oral administration of PG depends on suppression of Th17 lineage differentiation and an induction of Foxp3 + Treg cells (11,12). Additionally, daily oral administration of PG reduced the accumulation of M1 macrophages, which induce inflammation via the production of proinflammatory cytokines, in the adipose tissue of high-fat diet-induced obesity mice (14).…”

Section: Introductionmentioning

confidence: 99%

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Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice

et al. 2017

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Abstract. Proteoglycan (PG) is a complex glycohydrate that is widely distributed in the extracellular matrix. Oral administration of PG extracted from salmon nasal cartilage has been reported to attenuate the severity and proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen-induced arthritis and obesity-induced inflammation. In the present study, the effects of salmon nasal cartilage PG on skin allografts were investigated in a mouse model. Oral administration of PG prolonged the survival of skin grafts within 10 days of transplantation. Although PG failed to inhibit allograft rejection at the final stage of transplantation, PG attenuated the cell infiltration in the skin under the transplanted site.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice

et al. 2017

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“…In the present study, the effect of PG on allergic responses in a mouse model of papain-induced respiratory inflammation was investigated. The amount of PG and the starting time of administration were designed based on our previous studies (6)(7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

“…Based on its amino acid sequence, 46 serine residues are estimated to attach to sugar chains and the disaccharide composition in these sugar chains contains 60% of chondroitin-6 sulfate (3). Our previous studies have demonstrated that salmon PG has an immunomodulatory effect (5)(6)(7)(8)(9). Salmon PG suppresses inflammatory responses from mouse macrophages induced by heat-killed Escherichia coli (5).…”

Section: Introductionmentioning

confidence: 99%

“…Salmon PG suppresses inflammatory responses from mouse macrophages induced by heat-killed Escherichia coli (5). In mouse experimental models, daily oral administration of salmon PG attenuates the severity of inflammatory colitis (6), autoimmune encephalomyelitis (EAE) (7), collagen-induced arthritis (8) and obesity-induced inflammation (9). The attenuation of systemic inflammation in colitis and EAE models by daily oral administration of PG is associated with a reduction in T helper (Th)17 lineage differentiation and enhancement of Foxp3 + regulatory T cells (6,7).…”

Section: Introductionmentioning

confidence: 99%

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Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation

et al. 2018

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Proteoglycan (PG) is a complex glycohydrate, which is widely distributed in the extracellular matrix. It has been reported that daily oral administration of PG (extracted from salmon nasal cartilage) modulates the severity of proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen‑induced arthritis and obesity‑induced inflammation. The present study investigated the effect of salmon nasal cartilage PG on allergic responses using a mouse model of papain‑induced respiratory inflammation. Low titers of immunoglobulin E were identified in the sera of the PG‑administered mice. Oral administration of PG attenuated eosinophil infiltration in the lung. In the acute model of papain‑induced allergic inflammation, PG‑administered mice exhibited low titers of epithelium‑derived and T helper 2‑associated cytokines. The results of the present study demonstrated that salmon cartilage PG has an immunomodulatory effect on intranasally delivered papain. These results suggest a potential role for PG as a prophylactic agent which may attenuate allergic respiratory inflammation.

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Effects of salmon cartilage proteoglycan on obesity in mice fed with a high‐fat diet

Hirose

Asano

Harada³

et al. 2021

Food Science & Nutrition

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This study investigated the effects of salmon nasal cartilage proteoglycan (PG), which shows anti‐inflammatory properties, on obesity induced by high‐fat diet (HFD) in a mouse model. Mice were fed either a HFD or normal diet (ND), with or without PG, for 8–12 weeks. After 12 weeks, the body weight of mice fed with PG‐free HFD was 54.08 ± 4.67 g, whereas that of mice fed with HFD containing PG was 41.83 ± 4.97 g. The results suggest that the increase in body weight was attenuated in mice fed with HFD containing PG. This effect was not observed in mice fed with ND. The PG administration suppressed the elevation of serum lipids (the level of serum lipids ranged between 54% and 69% compared to 100% in mice fed with PG‐free HFD) and the upregulated mRNA expression of sterol regulatory element‐binding protein‐1c (SREBP‐1c), which is a transcription factor that acts as a master regulator of lipogenic gene expression in the liver (the expression level was 77.5% compared to 100% in mice fed with PG‐free HFD). High leptin levels in mice fed with PG‐free HFD were observed during fasting (average at 14,376 ng/ml), and they did not increase after refeeding (average of 14,263 ng/ml), whereas serum leptin levels in mice fed with HFD containing PG were low during fasting (average of 6481 ng/ml) and increased after refeeding (average 13,382 ng/ml). These results suggest that PG feeding has an anti‐obesity effect and that the regulation of SREBP‐1c and leptin secretion play a role in this effect.

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Attenuation of obesity-induced inflammation in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent

Cited by 13 publications

References 24 publications

Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice

Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice

Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation

Effects of salmon cartilage proteoglycan on obesity in mice fed with a high‐fat diet

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