Attenuation of Morphine-Induced Tolerance and Dependence by Pretreatment with Cerebrolysin in Male rats

Abstract

In conclusion, it was found that pretreatment with Cerebrolysin could attenuated morphine-induced tolerance and dependence.

Abstracts and Citations

“…Perhaps this relates to one study that demonstrated improvement in morphine tolerance and reduced withdrawal symptoms with Cerebrolysin therapy in an animal study. 6 I still reserve some skepticism, mostly from the origination of Cerebrolysin, but the treatments in the few human studies I have reviewed appeared to be well tolerated.…”

“…5 Despite preclinical and clinical data supporting the antinociceptive and potential antimigraine roles of cannabinoids, most headache clinicians have heeded the suggestion to wait for additional data. 6 Here Kandasamy and colleagues provide some additional preclinical data with rats on wheels, as reviewed by WMC. I find most interesting the potential "therapeutic window" effect where some THC was helpful, but too much THC was detrimental.…”

“…Actions of both endogenous and synthetic cannabinoid receptor agonists at presynaptic CB1 receptors have been shown to inhibit the release of glutamate via an inhibitory G-protein. 5,6 Here Eroli et al study the effects of anandamide, an endogenous ligand of the cannabinoid CB1 and CB2 receptors, which in prior work was shown to significantly inhibit neurogenic, CGRP-, and NO-induced dural vessel dilation in a rat intravital microscopy model of trigeminovascular activation. 7 The absence of impact on CSD was disappointing, but may reflect the complexity of endogenous cannabinoid activity within the central nervous system.…”

The Effect of Dihydromyricetin, a Natural Flavonoid, on Morphine-induced Conditioned Place Preference and Physical Dependence in Mice

“…Opioids are efficient painkillers medicines which used in treatment of severe pain [1]. However, psychological and physical dependence are restricting their use in clinical practice [2]. Finding new approaches to decrease physical and psychological dependence following opioids consumption while retaining their analgesic effects has been pursued in many studies [3,4].…”

An analysis of the peptide composition of a 'light' peptide fraction of cerebrolysin

“…Лекарственный препарат (ЛП) Церебролизин, изготавливаемый на основе пептидного экстракта мозга молодых свиней, проявляет нейротрофический и нейропротективный эффекты, важные для восстановления пациентов после ишемического инсульта (ИИ) и терапии деменции [1]. Экспериментальные исследования указали на нейротрофический [2], нейропротективный [3], ноотропный [4,5], противоболевой и противовоспалительный [6], антиконвульсантный [7] и противоопухолевый [8] эффекты ЛП Церебролизин. Клинические исследования показали эффективность и безопасность использования ЛП Церебролизин для терапии острого ИИ [9], после черепно-мозговых травм (ЧМТ) и субарахноидальных кровоизлияний [10], при когнитивных нарушениях [11] и расстройствах аутистического спектра [12], а также подтвердили противовоспалительный и антиоксидантный эффекты [13].…”