Attenuation of Morphine-Induced Behavioral Changes in Rodents byd-andl-Glucose

Talley, Cheryl; Arankowsky‐Sandoval, Gloria; McCarty, Richard; Gold, Paul E.

doi:10.1006/nlme.1998.3861

Cited by 17 publications

(2 citation statements)

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“…It has also been reported that systemic or intrahippocampal injection of glucose or its metabolite pyruvate attenuates acute morphine-induced memory impairment and increment of locomotor activity [6,[22][23][24][25]. In addition, glucose has also been shown to suppress acute morphine withdrawal signs in rodents and in guinea-pig ileum [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment

Chen

Lü

Gong³

et al. 2007

Cell Res

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Cell Research (2007) 17:689-700. © 2007 IBCB, SIBS, CAS All rights reserved 1001-0602/07 $ 30.00 www.nature.com/cr npg Dependence and impairment of learning and memory are two well-established features caused by abused drugs such as opioids. The hippocampus is an important region associated with both drug dependence and learning and memory. However, the molecular events in hippocampus following exposure to abused drugs such as opioids are not well understood. Here we examined the effect of chronic morphine treatment on hippocampal protein expression by proteomic analyses. We found that chronic exposure of mice to morphine for 10 days produced robust morphine withdrawal jumping and memory impairment, and also resulted in a significant downregulation of hippocampal protein levels of three metabolic enzymes, including Fe-S protein 1 of NADH dehydrogenase, dihydrolipoamide acetyltransferase or E2 component of the pyruvate dehydrogenase complex and lactate dehydrogenase 2. Further real-time quantitative PCR analyses confirmed that the levels of the corresponding mRNAs were also remarkably reduced. Consistent with these findings, lower ATP levels and an impaired ability to convert glucose into ATP were also observed in the hippocampus of chronically treated mice. Opioid antagonist naltrexone administrated concomitantly with morphine significantly suppressed morphine withdrawal jumping and reversed the downregulation of these proteins. Acute exposure to morphine also produced robust morphine withdrawal jumping and significant memory impairment, but failed to decrease the expression of these three proteins. Intrahippocampal injection of d-glucose before morphine administration significantly enhanced ATP levels and suppressed morphine withdrawal jumping and memory impairment in acute morphine-treated but not in chronic morphine-treated mice. Intraperitoneal injection of high dose of d-glucose shows a similar effect on morphine-induced withdrawal jumping as the central treatment. Taken together, our results suggest that reduced expression of the three metabolic enzymes in the hippocampus as a result of chronic morphine treatment contributes to the development of drug-induced symptoms such as morphine withdrawal jumping and memory impairment.

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Section: Introductionmentioning

confidence: 99%

Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment

Chen

Lü

Gong³

et al. 2007

Cell Res

View full text Add to dashboard Cite

show abstract

“…Behavioral studies have demonstrated that the administration of D-glucose not only enhances memory but also blocks memory-impairment induced by morphine (Ragozzino and Gold 1995;Talley et al 1999). Both the memory impairment of morphine and its antinociceptive effects have been shown to be influenced by pretreatment of animals with glucose (Simon and Dewey 1981;Kimes and London 1989;Brase et al 1991).…”

Section: Introductionmentioning

confidence: 97%