Attenuation of malaria infection, paralysis and lesions in the central nervous system by low protein diets in rats

Bakker, N. P. M.; Eling, W.M.C.; Groot, A.M.Th. De; Sinkeldam, E.J.; Luyken, R.

doi:10.1016/0001-706x(92)90063-4

Cited by 13 publications

(12 citation statements)

References 10 publications

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“…Observations on body weight are not presented in detail. Body temperature, reticulocyte counts and microscopy of the brain were comparable to those described previously (Bakker et al 1992), but are not presented in this communication.…”

Section: Parameters Examinedsupporting

confidence: 77%

“…Mortality was high in the high-protein group, but absent in the other groups. We obtained comparable results using potato protein concentrate instead of casein (Bakker et al 1992). Death was generally preceded by paralysis, which was attributed to cerebral lesions as observed microscopically.…”

Section: Introductionsupporting

confidence: 66%

“…The test animals were fed purified, low-protein diets containing 8% crude protein as mixtures of protein concentrates (maize gluten, Purina soy protein isolate, type 500E, Purina Protein Erpe, Yperen, Belgium) and milk protein concentrate (Refit R HPA, the complete fraction of the proteins in cows milk, 88% crude protein) in combination with sucrose 10%, cellulose 5%, mineral mixture 3.5%, vitamin ADEK mixture 0.3%, B-vitamin mixture 0.2%, paminobenzoic acid 0.066%, and wheat starch up to 100%. The composition of the mineral and vitamin mixtures is described elsewhere (Bakker et al 1992). The maize gluten was replaced partly or completely by milk protein concentrate as indicated in the tables.…”

Section: Dietsmentioning

confidence: 99%

“…These rats survived Plasmodium berghei infections. However, when the protein quality was improved by replacing 20 g maize gluten protein by 20 g milk protein, high mortality (60%) occurred, which was preceded by paralysis (Bakker et al 1988). To confirm and extend these observations, a series of comparable bioassays was conducted in rats fed diets differing in type and level of protein.…”

Section: Introductionmentioning

confidence: 97%

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Rodent malaria in rats exacerbated by milk protein, attenuated by low‐protein vegetable diet

Doorne

Eling²,

Luyken

1998

Tropical Med Int Health

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Young male Wistar rats were fed a purified, vegetable, low-protein diet containing 6% protein from maize gluten and 2% from soy protein isolate, or comparable diets in which maize gluten was replaced partly or completely by the equivalent amount of a milk protein concentrate. Diets with adequate protein level (16% or 22%) served as a control. At 21 or 31 days of age, the rats were infected with 3000 or 100000 erythrocytes parasitized with Plasmodium berghei. Results reported include body weight, mortality, paralysis and parasitaemia. Dietary replacement of part of the maize gluten protein by milk protein increased weight gain, but aggravated the malaria, as shown by increases in parasitaemia, paralysis and mortality. The aggravating effect of milk protein was dose-dependent. With only 4% milk protein in an 8% total protein diet, the disease symptoms were nearly as severe as with diets adequate in protein level. With a vegetable-only 8% protein diet symptoms were considerably less severe.

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