Attenuation of hyperglycemia-associated dyslipidemic, oxidative, cognitive, and inflammatory crises via modulation of neuronal ChEs/NF-κB/COX-2/NOx, and hepatorenal functional deficits by the Tridax procumbens extract

Hogan, Itam Ako; Kuo, Yu‐Cheng; Abubakar, Abdulkadir; Lawal, Bashir; Agboola, Abdulhakeem Rotimi; Lukman, Halimat Yusuf; Onikanni, Sunday Amos; Olawale, Femi; Fadaka, Adewale Oluwaseun; Ibrahim, Yunusa Olatunji; Babalola, Shukurat Bisola; Batiha, Gaber El‐Saber; Albogami, Sarah; Alorabi, Mohammed; Waard, Michel De; Huang, Hsu‐Shan

doi:10.1016/j.biopha.2022.114114

Cited by 7 publications

(5 citation statements)

References 83 publications

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“…Herein, these findings suggested that blood glucose levels (both MBG and GLI) should be monitored more closely in patients with diabetes who underwent CABG to prevent delirium. Furthermore, liver and kidney as important metabolic organs become functionally impaired due to any metabolic disorder in patients with DM ( 33 ). Studies showed that disorder of the gut–liver–brain axis influences disease development and progression, including choline, blood–brain barrier, vagus nerve, and neurotransmitters ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database

Wang,

Mei

2024

Front. Endocrinol.

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AimStudy results on blood glucose and the risk of delirium in patients receiving cardiac surgery are inconsistent, and there is also a gap in how to manage blood glucose after coronary artery bypass grafting (CABG). This study focused on patients with diabetes mellitus (DM) undergoing CABG and explored the associations of different blood glucose-related indexes and blood glucose change trajectory with postoperative delirium (POD), with the aim of providing some information for the management of blood glucose in this population.MethodsData of patients with DM undergoing CABG were extracted from the Medical Information Mart for Intensive Care (MIMIC)-IV database in this retrospective cohort study. The blood glucose-related indexes included baseline blood glucose, mean blood glucose (MBG), mean absolute glucose (MAG), mean amplitude of glycemic excursions (MAGE), glycemic lability index (GLI), and largest amplitude of glycemic excursions (LAGE). The MBG trajectory was classified using the latent growth mixture modeling (LGMM) method. Univariate and multivariate logistic regression analyses were utilized to screen covariates and explore the associations of blood glucose-related indexes and MBG trajectory with POD. These relationships were also assessed in subgroups of age, gender, race, estimated glomerular filtration rate (eGFR), international normalized ratio (INR), sepsis, mechanical ventilation use, and vasopressor use. In addition, the potential interaction effect between blood glucose and hepatorenal function on POD was investigated. The evaluation indexes were odds ratios (ORs), relative excess risk due to interaction (RERI), attributable proportion of interaction (AP), and 95% confidence intervals (CIs).ResultsAmong the eligible 1,951 patients, 180 had POD. After adjusting for covariates, higher levels of MBG (OR = 3.703, 95% CI: 1.743–7.870), MAG >0.77 mmol/L/h (OR = 1.754, 95% CI: 1.235–2.490), and GLI >2.6 (mmol/L)2/h/per se (OR = 1.458, 95% CI: 1.033–2.058) were associated with higher odds of POD. The positive associations of MBG, MAG, and GLI with POD were observed in patients aged <65 years old, male patients, White patients, those with eGFR <60 and INR <1.5, patients with sepsis, and those who received mechanical ventilation and vasopressors (all p < 0.05). Patients with class 3 (OR = 3.465, 95% CI: 1.122–10.696) and class 4 (OR = 3.864, 95% CI: 2.083–7.170) MBG trajectory seemed to have higher odds of POD, compared to those with a class 1 MBG trajectory. Moreover, MAG (RERI = 0.71, 95% CI: 0.14–1.27, AP = 0.71, 95% CI: 0.12–1.19) and GLI (RERI = 0.78, 95% CI: 0.19–1.39, AP = 0.69, 95% CI: 0.16–1.12) both had a potential synergistic effect with INR on POD.ConclusionFocusing on levels of MBG, MAG, GLI, and MBG trajectory may be more beneficial to assess the potential risk of POD than the blood glucose level upon ICU admission in patients with DM undergoing CABG.

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Section: Discussionmentioning

confidence: 99%

Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database

Wang,

Mei

2024

Front. Endocrinol.

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“…We conducted the procedure for the HRBC membrane stabilization assay following established protocols ( Hogan et al, 2023 ). In summary, 2 ml reaction mixtures were prepared by combining varying amounts of EFSFL or a standard diclofenac drug with a 10% suspension of red blood cells.…”

Section: Methodsmentioning

confidence: 99%

“…We carried out this assay to measure the inhibition of protein denaturation by following the procedure described by Hogan et al (2023) . The test sample included different concentrations of EFSFL and/or standard diclofenac, with a 10 µl 1% solution of bovine serum albumin.…”

Section: Methodsmentioning

confidence: 99%

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GC-MS chemical profiling, antioxidant, anti-diabetic, and anti-inflammatory activities of ethyl acetate fraction of Spilanthes filicaulis (Schumach. and Thonn.) C.D. Adams leaves: experimental and computational studies

Ojo,

Ogunlakin,

Gyebi

et al. 2023

Front. Pharmacol.

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Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities of the ethyl acetate fraction of Spilanthes filicaulis leaves (EFSFL) via experimental and computational studies.Methods: After inducing oxidative damage with FeSO4, we treated the tissues with different concentrations of EFSFL. An in-vitro analysis of EFSFL was carried out to determine its potential for antioxidant, anti-diabetic, and anti-inflammatory activities. We also measured the levels of CAT, SOD, GSH, and MDA.Results and discussion: EFSFL exhibited anti-inflammatory properties through membrane stabilizing properties (IC50 = 572.79 μg/ml), proteinase inhibition (IC50 = 319.90 μg/ml), and inhibition of protein denaturation (IC50 = 409.88 μg/ml). Furthermore, EFSFL inhibited α-amylase (IC50 = 169.77 μg/ml), α-glucosidase (IC50 = 293.12 μg/ml) and DPP-IV (IC50 = 380.94 μg/ml) activities, respectively. Our results indicated that induction of tissue damage reduced the levels of GSH, SOD, and CAT activities, and increased MDA levels. However, EFSFL treatment restores these levels to near normal. GC-MS profiling shows that EFSFL contains 13 compounds, with piperine being the most abundant. In silico interaction of the phytoconstituents using molecular and ensembled-based docking revealed strong binding tendencies of two hit compounds to DPP IV (alpha-caryophyllene and piperine with a binding affinity of −7.8 and −7.8 Kcal/mol), α-glucosidase (alpha-caryophyllene and piperine with a binding affinity of −9.6 and −8.9 Kcal/mol), and to α-amylase (piperine and Benzocycloheptano[2,3,4-I,j]isoquinoline, 4,5,6,6a-tetrahydro-1,9-dihydroxy-2,10-dimethoxy-5-methyl with a binding affinity of −7.8 and −7.9 Kcal/mol), respectively. These compounds also presented druggable properties with favorable ADMET. Conclusively, the antioxidant, antidiabetic, and anti-inflammatory activities of EFSFL could be due to the presence of secondary metabolites.

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“…Blood samples were collected by cardiac puncture into ethylene diamine tetra acetic acid (EDTA) bottles. Hematological examination was performed as previously described by Ebohon et al, 13 using an automated hematological analyzer (Beckman Coulter JT series Hematological Analyser). The hematological parameters of interest that were estimated include; white blood cell (WBC) count, Red blood cells (RBC) count, hemoglobin (HGB), mean corpuscular hemoglobin concentration, mean corpuscular volume, monocyte, neutrophil, lymphocyte and platelet count.…”

Section: Hematological Assaysmentioning

confidence: 99%

Anti-inflammatory, Analgesic and GCMS Analysis of Ethanol Extract of a Polyherbal Phytomedicine Used in Nigerian Ethnomedicine

2023

TJNPR

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The use of non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, and corticosteroids had been the treatment approach for inflammation via the inhibition of cyclooxygenase 2 (COX2). However, long-term usage threatens the human organs such as the liver, kidneys and the gastrointestinal tract due to their side effects. 3 Hence, the need for an alternative with lesser or no adverse effect while proffering a comparable therapeutic effect for the treatment of inflammation cannot be overemphasized. Traditional remedies have recently gained increased acceptance and application in Africa as inflammatory-related diseases, epidemics, and pandemics appear to be on the increase. 4 Medicinal plants have proved to be an excellent alternative to conventional medicines due to their richness in diverse types of phytochemicals and micronutrients such as alkaloids, flavonoids, terpenes, tannins, saponins, zinc, iron etc. These phytochemicals are responsible for the therapeutic activities of medicinal plants such as antioxidant, antimicrobial, antidiabetic, anticancer, neuroprotective effects. 3,4 Ginger -Zingiber officinale Roscoe (family Zingiberaceae) is one of the plants prominently used for several disease management. It is abundant in different bioactive compounds and minerals. Its fresh form contains mainly gingerols (6-gingerol, 8-gingerol, and 10-gingerol), which are converted to shogaols after heating, 5 and finally to paradols upon hydrogenation. In addition to the gingerols and its derivatives, there are also several other phenols in ginger such as zingerone,

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Attenuation of hyperglycemia-associated dyslipidemic, oxidative, cognitive, and inflammatory crises via modulation of neuronal ChEs/NF-κB/COX-2/NOx, and hepatorenal functional deficits by the Tridax procumbens extract

Cited by 7 publications

References 83 publications

Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database

Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database

GC-MS chemical profiling, antioxidant, anti-diabetic, and anti-inflammatory activities of ethyl acetate fraction of Spilanthes filicaulis (Schumach. and Thonn.) C.D. Adams leaves: experimental and computational studies

Anti-inflammatory, Analgesic and GCMS Analysis of Ethanol Extract of a Polyherbal Phytomedicine Used in Nigerian Ethnomedicine

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