Attenuation of high-fat high-sucrose diet and CCl4-induced non-alcoholic steatohepatitis in rats by activating autophagy and SIGMAR1/GRP78/ITPR1 signaling using berberine-loaded albumin nanoparticles: in vivo prediction and in-silico molecular modeling
Samar R. Saleh,
Fatema A. Younis,
Sahar S. Abdelrahman
et al.
Abstract:Purpose
Non-alcoholic fatty liver disease is the most prevalent metabolic disorder that can lead to the development of non-alcoholic steatohepatitis (NASH) and, eventually, result in hepatocellular carcinoma. This study evaluated the therapeutic potential of berberine-loaded bovine serum albumin nanoparticles (BBR-BSA NPs) toward the induced NASH physical, biochemical, and ultrastructural changes.
Methods
NASH was induced in male rats by an high-fat high-s… Show more
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