Attenuation of Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation: A Comparative Study Between Oral Gabapentin and Oral Clonidine.

Abstract

Background and Aims: Various methods have been used to supress pressor response and tachycardia during laryngoscopy and endotracheal intubation. We compared oral gabapentin and oral clonidine for surgeries under general anaesthesia. After clearance from IEC, sixty patients receiving general anae Methods: sthesia were divided into two groups, GROUP C and GROUP G. Group C received tablet Clonidine 200 µg. Group G received capsule Gabapentin 700 mg. Data was analysed using Student-t test for normal distribution and Mann-Whitney U test when not normally distributed. Qualitative data (n%) was compared using Chi-square test. Hemodynamic p Result: arameters rise on laryngoscopy and 1 minute after endotracheal intubation in both the groups. Further hemodynamic parameters dropped below baseline in both groups subsequently. But as compared to Group C, Group G has less rise in hemodynamic variables. Conclusion: Gabapentin was more effective and better than clonidine in attenuating hemodynamic response to laryngoscopy and endotracheal intubation overall