“…Although 5-HT 2A receptor antagonists (e.g., ethoxy]amino}-3-(2-fluorophenyl)prop-2-en-1-ylidene]cyclohexa-2,5-dien-1-one) and M100907 [a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenylethyl)]-4-piperidine methanol]) inhibit the effectiveness of noncontingent cocaine injections to reinstate extinguished responding for cocaine (cocaine-primed reinstatement) at doses that do not alter the ongoing self-administration of cocaine (Fletcher et al, 2002;Filip et al, 2005;Murnane et al, 2013), 5-HT 2C receptor agonists (e.g., Ro60-0175 [(S)-2(6-chloro-5-fluorindol-1-yl)-1-methylethylamine] and WAY163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b] [1,4]diazepino [6,7,1hi]indole]) dose-dependently inhibit the effectiveness of cocaine primes and cocaine-associated stimuli (stimulus-induced reinstatement) to reinstate extinguished responding, as well as the direct reinforcing effects of cocaine in self-administration procedures (Grottick et al, 2000;Burmeister et al, 2004;Burbassi and Cervo, 2008;Cunningham et al, 2011;Manvich et al, 2012;Rüedi-Bettschen et al, 2015). These findings suggest that 5-HT 2C receptor-selective agonists might be effective for reducing cocaine abuse and for prolonging abstinence.…”