Attenuation of atherosclerotic complications by modulating inflammatory responses in hypercholesterolemic rats with dietary Njavara rice bran oil

Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

“…It has been evident that the plant sterols and γ-oryzanol content of RBO in addition to its vitamin E and tocotrienol constituent, which show anti-atherogenic and antioxidant activities, may predominantly contribute to ameliorating hyperlipidemia, hypercholesterolemia, hyperglycemia, hyperinsulinemia, inflammation and lipid peroxidation. Of note, γ-oryzanol constituent of RBO was also indicated to diminish the concentration of plasma non-HDL cholesterol levels, possibly via promoting the release of bile acids and cholesterol in the feces [33,35,37,[43][44][45][46][47][48][49][50][51][52][53]. The available evidence indicates that RBO might reduce triglyceride concentration by averting the formation of very low-density lipoprotein cholesterol (VLDL-C) and the lipoproteins that contain apolipoprotein-B100.…”

Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors

“…antioxidant, anti-inflammatory and cholesterol-lowering properties in human subjects and rodents [14,53,54]. Though dietary supplementations of respective R.RBE and P.RBE as demonstrated in the present study significantly improved plasma lipid profile (reduced levels of total cholesterol and triglycerides) and decreased aortic plaque sizes of HFD-fed Ldlr À/mice, the underlying hypolipidemic properties of both R.RBE and P.RBE in the context of this study remains warranted.…”

“…Presently, interest in health attributes of rice bran as functional food has been intensified with focuses primarily centered on the evaluation of rice bran antioxidants in management of health and wellness. Some of the recently reported health attributes of rice bran were associated with its potent anti-atherogenic [11,12,13,14,15], chemopreventive [16,17], hypoglycemic [18], anti-hypertensive, and hypocholesterolemic [19,20] properties.…”

Human induced pluripotent stem cell‑derived mesenchymal stem cells alleviate atherosclerosis by modulating inflammatory responses

“…The authors acknowledged that immune rejection may occur in the current study, immunocompromized mice will be used in their future studies. Furthermore, AS is a complex process involving innate and adaptive immune mechanism ( 43 ). Whether the immune responses, like T cell responses or interferon-γ produced by T helper 1 cells, are involved requires future study.…”