Attenuation of aortic aneurysms with stem cells from different genders

Davis, John Staige; Salmon, Morgan; Pope, Nicolas H.; Lu, Guanyi; Su, Gang; Sharma, Ashish K.; Ailawadi, Gorav; Upchurch, Gilbert R.

doi:10.1016/j.jss.2015.04.025

Cited by 24 publications

(26 citation statements)

References 26 publications

(38 reference statements)

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“…The mice receiving stem cells had smaller AAAs and the elastin fragmentation was less pronounced. In another mouse study mesenchymal stem cells from a female donor were more effective in attenuating the growth of AAA than cells from male donors [67]. These three studies raised the possibility of localized replenishment therapy in the aneurysm wall, in which the stem cells could promote aortic ECM stability by secreting growth factors and cytokines necessary for healing.…”

Section: Pathophysiology Of Aaamentioning

confidence: 99%

Understanding the pathogenesis of abdominal aortic aneurysms

Kuivaniemi

Ryer

Elmore

et al. 2015

Expert Review of Cardiovascular Therapy

298

240

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Summary An aortic aneurysm is a dilatation in which the aortic diameter is ≥ 3.0 cm. If left untreated, the aortic wall continues to weaken and becomes unable to withstand the forces of the luminal blood pressure resulting in progressive dilatation and rupture, a catastrophic event associated with a mortality of 50 – 80%. Smoking and positive family history are important risk factors for the development of abdominal aortic aneurysms (AAA). Several genetic risk factors have also been identified. On the histological level, visible hallmarks of AAA pathogenesis include inflammation, smooth muscle cell apoptosis, extracellular matrix degradation, and oxidative stress. We expect that large genetic, genomic, epigenetic, proteomic and metabolomic studies will be undertaken by international consortia to identify additional risk factors and biomarkers, and to enhance our understanding of the pathobiology of AAA. Collaboration between different research groups will be important in overcoming the challenges to develop pharmacological treatments for AAA.

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Section: Pathophysiology Of Aaamentioning

confidence: 99%

Understanding the pathogenesis of abdominal aortic aneurysms

Kuivaniemi

Ryer

Elmore

et al. 2015

Expert Review of Cardiovascular Therapy

298

240

View full text Add to dashboard Cite

show abstract

“…Furthermore, when conditioned media from MSCs was injected (i.v.) to male mice AAA formation was atenuated [60]. Moreover, the 5-alpha-reductase inhibitor, inasteride, decreased proinlammatory cytokine expression in male MSCs [60].…”

Section: Inluences Of Sex Hormones On Aaa Development and Progressionmentioning

confidence: 97%

“…to male mice AAA formation was atenuated [60]. Moreover, the 5-alpha-reductase inhibitor, inasteride, decreased proinlammatory cytokine expression in male MSCs [60]. In humans, endothelial progenitor cells from AAA patients are impaired [61].…”

Section: Inluences Of Sex Hormones On Aaa Development and Progressionmentioning

confidence: 99%

“…Recent studies indicate that bone marrow-derived mesenchymal stem cells (MSCs) exhibit sex-dependent efects that inluence AAA development [60]. When female MSCs were injected into male mice, elastase-induced AAAs were atenuated [60].…”

Section: Inluences Of Sex Hormones On Aaa Development and Progressionmentioning

confidence: 99%

“…When female MSCs were injected into male mice, elastase-induced AAAs were atenuated [60]. Furthermore, when conditioned media from MSCs was injected (i.v.)…”

Section: Inluences Of Sex Hormones On Aaa Development and Progressionmentioning

confidence: 99%

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Sexual Dimorphism of Abdominal Aortic Aneurysms

Alsiraj¹,

Thatcher²,

Cassis³

2017

Aortic Aneurysm

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Sex is the largest nonmodiiable risk factor for the development of abdominal aortic aneurysms (AAAs) in humans and experimental models. Data from several studies consistently demonstrate a higher AAA prevalence in males than in females, contributing to divergent recommendations for AAA screening in men and women. Despite a higher AAA prevalence in males, females have more rapid rates of aneurysm dilation, and aneurysms rupture at smaller sizes. Unfortunately, no therapies have been efective to retard aneurysm dilation in either sex. Results from experimental AAA models indicate a protective role for estrogen in AAA development and progression, while male testosterone has been demonstrated to markedly promote angiotensin II (AngII)-induced AAAs. Potential mechanisms implicated in sex hormone regulation of AAAs include regulation of inlammation, matrix metalloproteinases, aromatase activity, oxidative stress, stem cells, and transforming growth factor-beta. In addition to sex hormones, sex chromosomes have been implicated in diseases of the aorta. Turner's syndrome (monosomy X) patients have a high incidence of thoracic aortic rupture. Recent studies indicate a novel approach to deine the relative role of sex hormones versus sex chromosomes in experimental AAAs. Further studies are warranted to determine interactions between sex hormones and sex chromosomes in AAA development and progression.

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Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review

Sunderland

Jiang

Zhao

2021

Journal Cellular Physiology

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Aneurysms are malformations within the arterial vasculature brought on by the structural breakdown of the microarchitecture of the vessel wall, with aneurysms posing serious health risks in the event of their rupture. Blood flow within vessels is generally laminar with high, unidirectional wall shear stressors that modulate vascular endothelial cell functionality and regulate vascular smooth muscle cells. However, altered vascular geometry induced by bifurcations, significant curvature, stenosis, or clinical interventions can alter the flow, generating low stressor disturbed flow patterns. Disturbed flow is associated with altered cellular morphology, upregulated expression of proteins modulating inflammation, decreased regulation of vascular permeability, degraded extracellular matrix, and heightened cellular apoptosis. The understanding of the effects disturbed flow has on the cellular cascades which initiate aneurysms and promote their subsequent growth can further elucidate the nature of this complex pathology. This review summarizes the current knowledge about the disturbed flow and its relation to aneurysm pathology, the methods used to investigate these relations, as well as how such knowledge has impacted clinical treatment methodologies. This information can contribute to the understanding of the development, growth, and rupture of aneurysms and help develop novel research and aneurysmal treatment techniques.

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Attenuation of aortic aneurysms with stem cells from different genders

Cited by 24 publications

References 26 publications

Understanding the pathogenesis of abdominal aortic aneurysms

Understanding the pathogenesis of abdominal aortic aneurysms

Sexual Dimorphism of Abdominal Aortic Aneurysms

Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review

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